Acute escitalopram but not contextual conditioning exerts a stronger "anxiogenic" effect in rats with high baseline "anxiety" in the acoustic startle paradigm.
Artikel i vetenskaplig tidskrift, 2015
Acute administration of selective serotonin reuptake inhibitors (SSRIs) may enhance anxiety in humans, those with anxiety disorders being more susceptible than others. Fear-conditioned or unconditioned acoustic startle and freezing are common measures of fear and/or "anxiety" in rodents that may be used to study this effect of SSRIs preclinically.
Författare
Robert Pettersson
Göteborgs universitet
Jakob Näslund
Göteborgs universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Matematisk statistik
Elias Eriksson
Göteborgs universitet
S Melker Hagsäter
Göteborgs universitet
Psychopharmacology
0033-3158 (ISSN) 14322072 (eISSN)
Vol. 232 8 1461-1469Ämneskategorier
Farmaceutisk vetenskap
Styrkeområden
Livsvetenskaper och teknik (2010-2018)
DOI
10.1007/s00213-014-3783-z
PubMed
25417552