Acute escitalopram but not contextual conditioning exerts a stronger "anxiogenic" effect in rats with high baseline "anxiety" in the acoustic startle paradigm.
Artikel i vetenskaplig tidskrift, 2015

Acute administration of selective serotonin reuptake inhibitors (SSRIs) may enhance anxiety in humans, those with anxiety disorders being more susceptible than others. Fear-conditioned or unconditioned acoustic startle and freezing are common measures of fear and/or "anxiety" in rodents that may be used to study this effect of SSRIs preclinically.

Författare

Robert Pettersson

Göteborgs universitet

Jakob Näslund

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Elias Eriksson

Göteborgs universitet

S Melker Hagsäter

Göteborgs universitet

Psychopharmacology

0033-3158 (ISSN)

Vol. 232 8 1461-1469

Ämneskategorier

Farmaceutisk vetenskap

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1007/s00213-014-3783-z

PubMed

25417552

Mer information

Skapat

2017-10-07