Imaging mass spectrometry in neuroscience.
Review article, 2013
Imaging mass spectrometry is an emerging technique of great potential for investigating the chemical architecture in biological matrices. Although the potential for studying neurobiological systems is evident, the relevance of the technique for application in neuroscience is still in its infancy. In the present Review, a principal overview of the different approaches, including matrix assisted laser desorption ionization and secondary ion mass spectrometry, is provided with particular focus on their strengths and limitations for studying different neurochemical species in situ and in vitro. The potential of the various approaches is discussed based on both fundamental and biomedical neuroscience research. This Review aims to serve as a general guide to familiarize the neuroscience community and other biomedical researchers with the technique, highlighting its great potential and suitability for comprehensive and specific chemical imaging.
Spectrometry
Matrix-Assisted Laser Desorption-Ionization
analysis
methods
Neurotransmitter Agents
Mass Spectrometry
Brain Chemistry
Mass
methods
Mass
Humans
Animals
Spectrometry
methods
Secondary Ion
Author
Jörg Hanrieder
Chalmers, Chemical and Biological Engineering, Analytical Chemistry
Nhu TN Phan
University of Gothenburg
Michael Kurczy
Chalmers, Chemical and Biological Engineering, Analytical Chemistry
Andrew Ewing
University of Gothenburg
Chalmers, Chemical and Biological Engineering, Analytical Chemistry
ACS Chemical Neuroscience
1948-7193 (eISSN)
Vol. 4 5 666-79Subject Categories
Chemical Sciences
DOI
10.1021/cn400053c
PubMed
23530951