Imaging mass spectrometry in neuroscience.
Reviewartikel, 2013

Imaging mass spectrometry is an emerging technique of great potential for investigating the chemical architecture in biological matrices. Although the potential for studying neurobiological systems is evident, the relevance of the technique for application in neuroscience is still in its infancy. In the present Review, a principal overview of the different approaches, including matrix assisted laser desorption ionization and secondary ion mass spectrometry, is provided with particular focus on their strengths and limitations for studying different neurochemical species in situ and in vitro. The potential of the various approaches is discussed based on both fundamental and biomedical neuroscience research. This Review aims to serve as a general guide to familiarize the neuroscience community and other biomedical researchers with the technique, highlighting its great potential and suitability for comprehensive and specific chemical imaging.

Spectrometry

Matrix-Assisted Laser Desorption-Ionization

analysis

methods

Neurotransmitter Agents

Mass Spectrometry

Brain Chemistry

Mass

methods

Mass

Humans

Animals

Spectrometry

methods

Secondary Ion

Författare

Jörg Hanrieder

Chalmers, Kemi- och bioteknik, Analytisk kemi

Nhu TN Phan

Göteborgs universitet

Michael Kurczy

Chalmers, Kemi- och bioteknik, Analytisk kemi

Andrew Ewing

Göteborgs universitet

Chalmers, Kemi- och bioteknik, Analytisk kemi

ACS Chemical Neuroscience

1948-7193 (ISSN)

Vol. 4 5 666-79

Ämneskategorier

Kemi

DOI

10.1021/cn400053c

PubMed

23530951

Mer information

Senast uppdaterat

2021-07-15