Imaging mass spectrometry in neuroscience.
Artikel i vetenskaplig tidskrift, 2013

Imaging mass spectrometry is an emerging technique of great potential for investigating the chemical architecture in biological matrices. Although the potential for studying neurobiological systems is evident, the relevance of the technique for application in neuroscience is still in its infancy. In the present Review, a principal overview of the different approaches, including matrix assisted laser desorption ionization and secondary ion mass spectrometry, is provided with particular focus on their strengths and limitations for studying different neurochemical species in situ and in vitro. The potential of the various approaches is discussed based on both fundamental and biomedical neuroscience research. This Review aims to serve as a general guide to familiarize the neuroscience community and other biomedical researchers with the technique, highlighting its great potential and suitability for comprehensive and specific chemical imaging.

methods

Brain Chemistry

Mass

Secondary Ion

methods

Mass

methods

Humans

Neurotransmitter Agents

analysis

Animals

Mass Spectrometry

Spectrometry

Matrix-Assisted Laser Desorption-Ionization

Spectrometry

Författare

Jörg Hanrieder

Chalmers, Kemi- och bioteknik, Analytisk kemi

Nhu TN Phan

Göteborgs universitet

Michael Kurczy

Chalmers, Kemi- och bioteknik, Analytisk kemi

Andrew Ewing

Chalmers, Kemi- och bioteknik, Analytisk kemi

Göteborgs universitet

ACS Chemical Neuroscience

1948-7193 (ISSN)

Vol. 4 666-79

Ämneskategorier

Kemi

DOI

10.1021/cn400053c

PubMed

23530951