Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia
Journal article, 2016

Preventing relapse after chemotherapy remains a challenge in acute myeloid leukemia (AML). Eighty-four non-transplanted AML patients in first complete remission received relapse-preventive immunotherapy with histamine dihydrochloride and low-dose interleukin-2 in an international phase IV trial (ClinicalTrials.gov; NCT01347996). Blood samples were drawn during cycles of immunotherapy and analyzed for CD8(+) (cytotoxic) T cell phenotypes in blood. During the first cycle of therapy, a re-distribution of cytotoxic T cells was observed comprising a reduction of T effector memory cells and a concomitant increase of T effector cells. The dynamics of T cell subtypes during immunotherapy prognosticated relapse and survival, in particular among older patients and remained significantly predictive of clinical outcome after correction for potential confounders. Presence of CD8(+) T cells with specificity for leukemia-associated antigens identified patients with low relapse risk. Our results point to novel aspects of T cell-mediated immunosurveillance in AML and provide conceivable biomarkers in relapse-preventive immunotherapy.

lymphocytes

acute myeloid leukemia

Cell Biology

immunotherapy

histamine dihydrochloride

Oncology

Immunology and

remission

antigen-specific T cells

maintenance

differentiation

effector

transplantation

responses

interleukin-2

cytotoxic T cells

memory

Author

Frida Ewald Sander

University of Gothenburg

Anna Rydström

University of Gothenburg

Elin Bernson

University of Gothenburg

Roberta Kiffin

University of Gothenburg

Rebecca E Riise

University of Gothenburg

Johan Aurelius

University of Gothenburg

H. Anderson

Mats Brune

University of Gothenburg

R. Foa

Kristoffer Hellstrand

University of Gothenburg

Fredrik B Thorén

University of Gothenburg

Anna Martner

University of Gothenburg

Oncotarget

1949-2553 (ISSN)

Vol. 7 7 7586-7596

Subject Categories

Clinical Medicine

DOI

10.18632/oncotarget.7210

PubMed

26863635

More information

Created

10/10/2017