Model-based optimization and scale-up of multi-feed simultaneous saccharification and co-fermentation of steam pre-treated lignocellulose enables high gravity ethanol production.
Journal article, 2016

High content of water-insoluble solids (WIS) is required for simultaneous saccharification and co-fermentation (SSCF) operations to reach the high ethanol concentrations that meet the techno-economic requirements of industrial-scale production. The fundamental challenges of such processes are related to the high viscosity and inhibitor contents of the medium. Poor mass transfer and inhibition of the yeast lead to decreased ethanol yield, titre and productivity. In the present work, high-solid SSCF of pre-treated wheat straw was carried out by multi-feed SSCF which is a fed-batch process with additions of substrate, enzymes and cells, integrated with yeast propagation and adaptation on the pre-treatment liquor. The combined feeding strategies were systematically compared and optimized using experiments and simulations.

Author

Ruifei Wang

Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Pornkamol Unrean

Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Carl Johan Franzén

Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Biotechnology for Biofuels

1754-6834 (eISSN)

Vol. 9 1 88- 88

Driving Forces

Sustainable development

Subject Categories

Industrial Biotechnology

Bioprocess Technology

Bioenergy

Microbiology

Other Industrial Biotechnology

Areas of Advance

Energy

Life Science Engineering (2010-2018)

DOI

10.1186/s13068-016-0500-7

PubMed

27096006

More information

Created

10/7/2017