Carl Johan Franzén

Docent at Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Carl Johan Franzén is Associate Professor in Bioreaction Engineering. His research deals with bioprocess development, kinetic modeling and control of microbial metabolism. He uses network and kinetic modeling and physiologically based control of bioprocesses to optimize production of chemicals using yeast cell factories. One key application is the development of bioethanol production from lignocellulosic raw materials. In recent years, he has developed methodology for encapsulation of yeast to improve the process robustness. The physiological consequences of this has been studied by e.g. proteomics.Carl Johan is also an active teacher and Head of Programme for the five-year MScEng Bioengineering program.

Source: chalmers.se

Projects

2016–2019

Bioethanol from spruce and oatshells via High Gravity Multi-Feed SSF

Carl Johan Franzén Industrial Biotechnology
Swedish Energy Agency

2013–2018

Upgrading of renewable domestic raw materials to value-added bulk and fine chemicals for a biobased economy: technology development, systems integration and environmental impact assessment (BioBuF)

Lisbeth Olsson Industrial Biotechnology
Anne-Marie Tillman Environmental Systems Analysis
Mathias Janssen Environmental Systems Analysis
Carl Johan Franzén Industrial Biotechnology
Elin Svensson Energy Technology
Simon Harvey Energy Technology
Thore Berntsson Energy Technology
Christel Cederberg Physical Resource Theory
Hans Theliander Forest Products and Chemical Engineering
Nikolaos Xafenias Industrial Biotechnology
Emma Karlsson Industrial Biotechnology
Maurizio Bettiga Industrial Biotechnology
Karin Pettersson Energy Technology
Joshua Mayers Industrial Biotechnology
Eva Albers Industrial Biotechnology
Valeria Mapelli Industrial Biotechnology
Christel Kampman Industrial Biotechnology
Stavros Papadokonstantakis Energy Technology
Västra Götalandsregionen, Regional development committee
Formas

2013–2015

Scale-Up: Multi-Feed SSF with integrated propagation of flocculating xylose-fermenting yeast

Carl Johan Franzén Industrial Biotechnology
Swedish Energy Agency

2015–2015

Analysis of present status and opportunities for bioprocesses integrated in biorefineries

Carl Johan Franzén Industrial Biotechnology
Swedish Energy Agency

2014–2015

A comparative analysis of water use in lignocellulosic ethanol processes

Carl Johan Franzén Industrial Biotechnology
Swedish Energy Agency

2013–2014

Skogskemi: Hållbara kemikalier och material

Matteo Morandin Industrial Energy Systems and Technologies
Carl Johan Franzén Industrial Biotechnology
Processum Biorefinery Initiative AB

There might be more projects where Carl Johan Franzén participates, but you have to be logged in as a Chalmers employee to see them.

Publications

2017

Bacillus coagulans MA-13: a promising thermophilic and cellulolytic strain for the production of lactic acid from lignocellulosic hydrolysate

Martina Aulitto, Salvatore Fusco, Simonetta Bartolucci et al
Biotechnology for Biofuels. Vol. 10 (1), p. Art. no 210-
Journal article
2016

Which methods for viable yeast cell quantification can be used in lignocellulosic fermentation processes

Ruifei Wang, Bettina Lorantfy, Salvatore Fusco et al
Conference poster
2016

Water Management in Lignocellulosic Ethanol Production- a Case Study and Comparative Analysis from a Swedish Perspective

Rickard Fornell, K. Willquist, A. Petersson et al
Chemical Engineering Transactions. Vol. 52, p. 703-708
Paper in proceedings
2016

Model-based optimization and scale-up of multi-feed simultaneous saccharification and co-fermentation of steam pre-treated lignocellulose enables high gravity ethanol production.

Ruifei Wang, Pornkamol Unrean, Carl Johan Franzén
Biotechnology for Biofuels. Vol. 9 (1), p. 88-
Journal article
2015

Characterization of the respiratory physiology of Lactococcus lactis for starter culture production with improved acidification capacity

Bettina Lorantfy, Carl Johan Franzén, Lisbeth Olsson et al
Conference contribution
2015

Dynamic flux balancing elucidates NAD(P)H production as limiting response to furfural inhibition in Saccharomyces cerevisiae

U. Pornkamol, Carl Johan Franzén
Biotechnology journal. Vol. 10 (8), p. 1248-1258
Journal article
2015

Multifeed simultaneous saccharification and fermentation enables high gravity submerged fermentation of lignocellulose.

Carl Johan Franzén, Ruifei Wang, Johan Westman et al
Conference contribution
2015

Current progress in high cell density yeast bioprocesses for bioethanol production

Johan Westman, Carl Johan Franzén
Biotechnology journal. Vol. 10 (8), p. 1185-1195
Journal article
2015

A FLO1 variant which yields a NewFlo phenotype

Johan Westman, Jonas Nyman, Rich Manara et al
Conference poster
2014

Flocculation Causes Inhibitor Tolerance in Saccharomyces cerevisiae for Second-Generation Bioethanol Production

Johan Westman, Valeria Mapelli, Mohammad Taherzadeh Esfahani et al
Applied and Environmental Microbiology. Vol. 80 (22), p. 6908-6918
Journal article
2014

Improved sugar co-utilisation by encapsulation of a recombinant Saccharomyces cerevisiae strain in alginate-chitosan capsules

Johan Westman, Nicklas Bonander, Mohammad Taherzadeh Esfahani et al
Biotechnology for Biofuels. Vol. 7 (1)
Journal article
2014

Process optimization of multi-feed SSCF

Ruifei Wang, Pornkamol Unrean, Lisbeth Olsson et al
Conference poster
2014

Kinetic modeling of multi-feed simultaneous saccharification and co-fermentation of pretreated birch to ethanol

Ruifei Wang, Rakesh Koppram, Lisbeth Olsson et al
Bioresource Technology. Vol. 172, p. 303-311
Journal article
2014

Continuous ethanol production with a membrane bioreactor at high acetic acid concentrations

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Membranes. Vol. 4 (3), p. 372-387
Journal article
2014

Improved fermentation of inhibitory lignocellulose hydrolysates by Saccharomyces cerevisiae at high local cell density

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference contribution
2014

Novel process strategies lead towards efficient bioethanol production at high solid loadings

Rakesh Koppram, Charilaos Xiros, Ruifei Wang et al
Conference poster
2013

Systems biology methods and developments for Saccharomyces cerevisiae and other industrial yeasts in relation to the production of fermented food and food ingredients

Valeria Mapelli, Carl Johan Franzén, Lisbeth Olsson
Microbial Production of Food Ingredients, Enzymes and Nutraceuticals, p. 42-80
Chapter in monograph, book - peer reviewed
2013

High local cell density for efficient 2nd generation bioethanol production by Saccharomyces cerevisiae

Johan Westman, Valeria Mapelli, Mohammad Taherzadeh Esfahani et al
Conference poster
2013

Impact of Furfural on Rapid Ethanol Production Using a Membrane Bioreactor

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Energies. Vol. 6 (3), p. 1604-1617
Journal article
2013

Impact of Furfural on Rapid Ethanol Production Using a Membrane Bioreactor

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Energies. Vol. 6 (3), p. 1604-1617
Journal article
2013

Rapid ethanol production by Saccharomyces cerevisiae in a membrane bioreactor

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Conference poster
2013

Together we are strong – Yeast flocculation for efficient fermentation of toxic hydrolysates

Johan Westman, Valeria Mapelli, Mohammad Taherzadeh Esfahani et al
Conference poster
2012

Encapsulation-Induced Stress Helps Saccharomyces cerevisiae Resist Convertible Lignocellulose Derived Inhibitors

Johan Westman, R. B. Manikondu, Carl Johan Franzén et al
International Journal of Molecular Sciences. Vol. 13 (9), p. 11881-11894
Journal article
2012

Inhibitor tolerance by high local cell density Saccharomyces cerevisiae cultures

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference poster
2012

Effects of encapsulation of microorganisms on product formation during microbial fermentations

Johan Westman, Päivi Ylitervo, Carl Johan Franzén et al
Applied Microbiology and Biotechnology. Vol. 96 (6), p. 1441-1454
Journal article
2012

Investigations of the inhibitor tolerance of encapsulated Saccharomyces cerevisiae

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference poster
2012

Physiological consequences of encapsulating Saccharomyces cerevisiae: A proteomic approach

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference contribution
2012

Proteomic analysis of the increased stress tolerance of Saccharomyces cerevisiae encapsulated in liquid core alginate-chitosan capsules

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
PLoS ONE. Vol. 7 (11), p. e49335-
Journal article
2012

Mechanically robust polysiloxane – ACA capsules for prolonged ethanol production

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Journal of Chemical Technology and Biotechnology. Vol. 88 (6), p. 1080-1088
Journal article
2012

Inhibitor tolerance and flocculation of a yeast strain suitable for second generation bioethanol production

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Electronic Journal of Biotechnology. Vol. 15 (3)
Journal article
2012

Robust liquid core APTES-alginate-chitosan-alginate capsules for 2nd generation bioethanol production

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Conference poster
2012

Physiological consequenses of high local cell density Saccharomyces cerevisiae cultures

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference poster
2012

Physiological consequences of encapsulating Saccharomyces cerevisiae: A proteomic approach

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference poster
2012

Robust polysiloxane-ACA capsules for ethanol production from wood hydrolyzate by yeast

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Conference poster
2011

Encapsulated vs. free yeast: A comparative proteomic study

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference poster
2011

Selective suppression of bacterial contaminants by process conditions during lignocellulose based yeast fermentations

Eva Albers, Emma Johansson, Carl Johan Franzén et al
Biotechnology for Biofuels. Vol. 4
Journal article
2011

Ethanol production at elevated temperatures using encapsulation of yeast

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Journal of Biotechnology. Vol. 156 (1), p. 22-29
Journal article
2011

Ethanol production at elevated temperatures using encapsulation of yeast

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Journal of Biotechnology. Vol. 156 (1), p. 22-29
Journal article
2011

Encapsulation of yeast for efficient 2nd generation bioethanol production: Finite element modeling of concentration profiles in encapsulated yeast

Joana Paula Da Costa Pereira, Goncalo Carvalho Esteves, Carl Johan Franzén
Conference poster
2011

Inhibitor tolerance and flocculation: Characterization of a yeast strain suitable for 2nd generation bioethanol production

Johan Westman, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference poster
2011

THERMOTOLERANCE OF ENCAPSULATED YEAST

Päivi Ylitervo, Mohammad Taherzadeh Esfahani, Carl Johan Franzén
Conference poster
2010

Increasing the thermotolerance of Saccharomyces cerevisiae by encapsulation

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Conference poster
2010

Phenotypical and Physiological Characterization of a Flocculating Yeast Strain

Johan Westman, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Conference poster
2010

Improving the stability and mechanical resistance of chitosan/alginate capsules for encapsulation of S. cerevisiae

Päivi Ylitervo, Carl Johan Franzén, Mohammad Taherzadeh Esfahani
Conference poster
2010

On-line monitoring of fermentation processes in lignocellulose-to-bioalcohol production.

Anna Eliasson Lantz, Krist V. Gernaey, Carl Johan Franzén et al
Bioalcohol production: Biochemical conversion of lignocellulosic biomass, p. 315-339
Chapter in monograph, book - peer reviewed
2010

Together we are strong! Inhibitor tolerance conferred by good neighbors?

Johan Westman, Farid Talebnia Rowshan, Carl Johan Franzén et al
Conference poster
2009

Ethanol production from lignocellulosic materials by encapsulated Saccharomyces cerevisiae

Päivi Ylitervo, Hamidreza Barghi, Carl Johan Franzén et al
Conference poster
2007

Characterization of glucose transport mutants of saccharomyces cerevisiae during a nutritional upshift reveals a correlation between metabolite levels and glycolytic flux

Daniel Bosch, Mikael Johansson, Cecilia Ferndahl et al
Fems Yeast research. Vol. 8, p. 10-25
Journal article
2007

Conservation laws and identifiability of rate expressions in biochemical models

Milena Anguelova, Gunnar Cedersund, Carl Johan Franzén et al
IET Systems Biology. Vol. 1 (4), p. 230-237
Journal article
2007

Continuous fermentation of wheat-supplemented lignocellulose hydrolysate with different types of cell retention

Tomas Brandberg, Keikhosro Karimi, Mohammad Taherzadeh Esfahani et al
Biotech. Bioeng.. Vol. 98 (1), p. 80-90
Journal article
2007

The impact of severe nitrogen limitation and microaerobic conditions on extended continuous cultivations of Saccharomyces cerevisiae with cell recirculation

Tomas Brandberg, Lena Gustafsson, Carl Johan Franzén
Enzyme and Microbial Technology. Vol. 40 (4), p. 585-593
Journal article
2005

Continuous fermentation of undetoxified dilute acid lignocellulose hydrolysate with Saccharomyces cerevisiae ATCC 96581 using cell recirculation

Tomas Brandberg, Nima Sanandaji, Lena Gustafsson et al
Biotechnology Progress. Vol. 21, p. 1093-1101
Journal article
2004

The fermentation performance of nine strains of Saccharomyces cerevisiae in batch and fed-batch cultures in dilute-acid wood hydrolysate

Tomas Brandberg, Carl Johan Franzén, Lena Gustafsson
J Biosci Bioeng. Vol. 98, p. 122-125
Journal article
2003

Effects of furfural on the respiratory metabolism of Saccharomyces cerevisiae in glucose-limited chemostats

Ilona Sárvári Horváth, Carl Johan Franzén, Claes Niklasson et al
Applied and Environmental Microbiology. Vol. 69 (7), p. 4076-4086
Journal article
2003

Carbon starvation can induce energy deprivation and a loss of fermentative capacity in Saccharomyces cerevisiae.

Elisabeth Thomsson, Christer Larsson, Eva Albers et al
Applied and Environmental Microbiology. Vol. 69, p. 3251-3257
Journal article
2003

Metabolic flux analysis of RQ-controlled microaerobic ethanol production by Saccharomyces cerevisiae

Carl Johan Franzén
Yeast. Vol. 20, p. 117-132
Journal article
2000

Microaerobic glycerol formation in Saccharomyces cerevisiae

Roeland Costenoble, Hadi Valadi, Claes Niklasson et al
Yeast. Vol. 16, p. 1483-1495
Journal article
1998

Modeling the fluxes of reducing equivalents in microaerobic RQ-controlled continuous cultures of Saccharomyces cerevisiae.

Carl Johan Franzén, Claes Niklasson
Larsson C, Påhlman I-L, and Gustafsson L (eds.): BioThermoKinetics in the Post Genomic Era, p. 383-387
Paper in proceedings
1996

Use of the inlet gas composition to control the respiratory quotient in microaerobic bioprocesses.

Carl Johan Franzén, Eva Albers, Claes Niklasson
Chemical Engineering Science. Vol. 51, p. 3391-3402
Journal article
1994

A new method for studying microaerobic fermentation: I. A theoretical analysis of oxygen programmed fermentation.

Gunnar Lidén, Carl Johan Franzén, Claes Niklasson
Biotechnology and Bioengineering. Vol. 44, p. 419-427
Journal article
1994

Experimental Methods for Microaerobic Bioprocesses

Carl Johan Franzén
Licentiate thesis
1994

An experimental guide to the relevant aeration rates in microaerobic bioprocesses.

Carl Johan Franzén, Gunnar Lidén, Claes Niklasson
Galindo E and Ramírez O (eds): Advances in Bioprocess Engineering. (Kluwer Academic Publishers), p. 255-265
Paper in proceedings
1994

A new method for studying microaerobic fermentation: II. An experimental investigation of xylose fermentation.

Carl Johan Franzén, Gunnar Lidén, Claes Niklasson
Biotechnology and Bioengineering. Vol. 44, p. 429-435
Journal article