Self-assembly of lipid domains in the extracellular leaflet of the plasma membrane and models thereof
Review article, 2016

Lipid domain formation and phase coexistence in biological membranes is a subject which has received considerable attention during the last two decades, especially the topic concerning so-called lipid rafts, a theory which has become as popular to confirm as to disproof. Regardless of the existence or precise composition and function of the classical rafts, the occurrence of lateral lipid segregation in biological membranes is indisputable. This review starts by focusing on state of the art findings concerning lipid domains and lateral heterogeneity in a biological context. Then, the physicochemical properties of lipid mixtures, phase properties and domain dynamics are considered. Canonical lipid models of the exofacial leaflet of the plasma membrane are treated in detail and the proper choices of model lipids are discussed. A special attention is given to polar lateral interactions (including carbohydrate-carbohydrate head group interactions), whose importance for spatial segregation and crystallization is commencing to be appreciated by the scientific community.

Lipid raft

Phase diagram

Line tension

Liquid ordered

IRRAS

Langmuir monolayer

Avidity

Ganglioside

Author

Markus Andersson Trojer

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Applied Surface Chemistry

Gerald Brezesinski

Max Planck Society

Current Opinion in Colloid and Interface Science

1359-0294 (ISSN)

Vol. 22 65-72

Subject Categories

Chemical Sciences

DOI

10.1016/j.cocis.2016.03.001

More information

Latest update

7/2/2021 6