Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications
Journal article, 2016

The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer. The RuAAC reaction has quickly found its way into the organic chemistry toolbox and found applications in many different areas, such as medicinal chemistry, polymer synthesis, organocatalysis, supramolecular chemistry, and the construction of electronic devices. This Review discusses the mechanism, scope, and applications of the RuAAC reaction, covering the literature from the last 10 years.

Author

Johan Johansson

AstraZeneca AB

Tamas Beke-Somfai

Hungarian Academy of Sciences

Anna Said Stålsmeden

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Organic Chemistry

Nina Kann

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Organic Chemistry

Chemical Reviews

0009-2665 (ISSN) 1520-6890 (eISSN)

Vol. 116 23 14726-14768

Driving Forces

Sustainable development

Roots

Basic sciences

Areas of Advance

Life Science Engineering (2010-2018)

Materials Science

Subject Categories

Chemical Sciences

Organic Chemistry

DOI

10.1021/acs.chemrev.6b00466

More information

Latest update

3/21/2018