Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications
Artikel i vetenskaplig tidskrift, 2016

The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer. The RuAAC reaction has quickly found its way into the organic chemistry toolbox and found applications in many different areas, such as medicinal chemistry, polymer synthesis, organocatalysis, supramolecular chemistry, and the construction of electronic devices. This Review discusses the mechanism, scope, and applications of the RuAAC reaction, covering the literature from the last 10 years.

Författare

Johan Johansson

AstraZeneca AB

Tamas Beke-Somfai

Magyar Tudomanyos Akademia

Anna Said Stålsmeden

Kemi och kemiteknik, Kemi och biokemi, Organisk kemi

Nina Kann

Kemi och kemiteknik, Kemi och biokemi, Organisk kemi

Chemical Reviews

0009-2665 (ISSN) 1520-6890 (eISSN)

Vol. 116 14726-14768

Drivkrafter

Hållbar utveckling

Fundament

Grundläggande vetenskaper

Styrkeområden

Livsvetenskaper och teknik

Materialvetenskap

Ämneskategorier

Kemi

Organisk kemi

DOI

10.1021/acs.chemrev.6b00466