Experimental Models for Neurotrauma Research
Journal article, 2016

Physical trauma in the central nervous system (CNS) is usually the result of a number of forces in different directions and dimensions. A large number of experimental models have been developed to improve the possibilities to understand the outcome of CNS trauma. In this chapter, we will describe the need for a variety of experimental models for research on traumatic brain injury (TBI) and spinal cord injury (SCI). Models can serve different needs, such as: to test new treatments for injuries, to reveal thresholds for injuries, to provide a better understanding of injury mechanisms, or to test tools and methods for translation between experiments and clinical data. In this chapter, we will discuss on the validation of models and translation between experimental and clinical studies.

White matter

Blast trauma

Mechanisms

Diffuse axonal injury (DAI)

Traumatic brain injury (TBI)

Author

Johan Davidsson

Chalmers, Applied Mechanics, Vehicle Safety

Mårten Risling

Methods in Molecular Biology

10643745 (ISSN)

Vol. 1462 267-88

Areas of Advance

Transport

Subject Categories

Neurosciences

More information

Created

10/7/2017