In vitro evaluation of osteoblastic cells on bacterial cellulose modified with multi-walled carbon nanotubes as scaffold for bone regeneration
Journal article, 2017
In this paper we explore the use of native bacterial cellulose (BC) in combination with functionalized multi-walled carbon nanotubes (MWNTs) as an original biomaterial, suitable three-dimensional (3D) scaffold for osteoblastic cell culture. Functionalized MWNTs were mixed with native BC (secreted by Gluconacetobacter xylinus) with the aim of reinforcing the mechanical properties of BC. The results indicate that BC-MWNTs scaffolds support osteoblast viability, adhesion and proliferation at higher levels as compared to traditional culture substrates. Chemically functionalized MWNTs are also an excellent material to be used as scaffold because these did not affect cell viability and showed an enhanced osteoblast adhesion. These results suggest the potential for this combination of biomaterials, i.e. BC and carbon nanomaterials, as scaffolds for bone regeneration.
Bone regeneration
Functionalized MWNTs
Bacterial cellulose
Osteoblastic cells
Cell adhesion
Author
José Manuel Gutiérrez-Hernández
University of Guadalajara
Universidad Autonoma de San Luis Potosi
Diana María Escobar-García
Polytechnic University of San Luis Potosí
Alfredo Escalante
University of Guadalajara
Hector Flores
Polytechnic University of San Luis Potosí
Francisco Javier González
Universidad Autonoma de San Luis Potosi
Paul Gatenholm
Chalmers, Chemistry and Chemical Engineering, Applied Chemistry
Guillermo Toriz Gonzalez
Chalmers, Chemistry and Chemical Engineering, Applied Chemistry
Materials Science and Engineering C
0928-4931 (ISSN) 18730191 (eISSN)
Vol. 75 445-453Driving Forces
Sustainable development
Areas of Advance
Building Futures (2010-2018)
Life Science Engineering (2010-2018)
Subject Categories
Industrial Biotechnology
DOI
10.1016/j.msec.2017.02.074