In vitro evaluation of osteoblastic cells on bacterial cellulose modified with multi-walled carbon nanotubes as scaffold for bone regeneration
Artikel i vetenskaplig tidskrift, 2017

In this paper we explore the use of native bacterial cellulose (BC) in combination with functionalized multi-walled carbon nanotubes (MWNTs) as an original biomaterial, suitable three-dimensional (3D) scaffold for osteoblastic cell culture. Functionalized MWNTs were mixed with native BC (secreted by Gluconacetobacter xylinus) with the aim of reinforcing the mechanical properties of BC. The results indicate that BC-MWNTs scaffolds support osteoblast viability, adhesion and proliferation at higher levels as compared to traditional culture substrates. Chemically functionalized MWNTs are also an excellent material to be used as scaffold because these did not affect cell viability and showed an enhanced osteoblast adhesion. These results suggest the potential for this combination of biomaterials, i.e. BC and carbon nanomaterials, as scaffolds for bone regeneration.

Bone regeneration

Functionalized MWNTs

Bacterial cellulose

Osteoblastic cells

Cell adhesion


José Manuel Gutiérrez-Hernández

Universidad de Guadalajara

Universidad Autonoma de San Luis Potosi

Diana María Escobar-García

Universidad Politécnica de San Luis Potosí

Alfredo Escalante

Universidad de Guadalajara

Hector Flores

Universidad Politécnica de San Luis Potosí

Francisco Javier González

Universidad Autonoma de San Luis Potosi

Paul Gatenholm

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Guillermo Toriz Gonzalez

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Materials Science and Engineering C

0928-4931 (ISSN) 18730191 (eISSN)

Vol. 75 445-453


Hållbar utveckling


Building Futures (2010-2018)

Livsvetenskaper och teknik (2010-2018)


Industriell bioteknik



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