Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment–gynecological cancer survivors
Journal article, 2017

Background: It is unknown whether smoking; age at time of radiotherapy or time since radiotherapy influence the intensity of late radiation-induced bowel syndromes. Material and methods: We have previously identified 28 symptoms decreasing bowel health among 623 gynecological-cancer survivors (three to twelve years after radiotherapy) and 344 matched population-based controls. The 28 symptoms were grouped into five separate late bowel syndromes through factor analysis. Here, we related possible predictors of bowel health to syndrome intensity, by combining factor analysis weights and symptom frequency on a person-incidence scale. Results: A strong (p <.001) association between smoking and radiation-induced urgency syndrome was found with a syndrome intensity (normalized factor score) of 0.4 (never smoker), 1.2 (former smoker) and 2.5 (current smoker). Excessive gas discharge was also related to smoking (p =.001). Younger age at treatment resulted in a higher intensity, except for the leakage syndrome. For the urgency syndrome, intensity decreased with time since treatment. Conclusions: Smoking aggravates the radiation-induced urgency syndrome and excessive gas discharge syndrome. Smoking cessation may promote bowel health among gynecological-cancer survivors. Furthermore, by understanding the mechanism for the decline in urgency-syndrome intensity over time, we may identify new strategies for prevention and alleviation.

Author

Gunnar Steineck

Sahlgrenska Academy

Karolinska University Hospital

Fei Sjöberg

Sahlgrenska Academy

Viktor Skokic

Sahlgrenska Academy

Cecilia Bull

Sahlgrenska Academy

Ulrica Wilderäng

Sahlgrenska Academy

Eleftheria Alevronta

Sahlgrenska Academy

Gail Dunberger

Ersta Sköndal University Collage

Karin Bergmark

Sahlgrenska Academy

Rebecka Jörnsten

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

University of Gothenburg

Acta Oncologica

0284-186X (ISSN) 1651-226X (eISSN)

Vol. 56 5 682-691

Subject Categories

Mathematics

Roots

Basic sciences

DOI

10.1080/0284186X.2017.1307519

PubMed

28366105

More information

Latest update

9/6/2018 2