Solid supported active esters as linkers: modification of reactivity using iron carbonyl complexes
Journal article, 2006

The reactivity of three polymer-bound cyclohexadienoic acid active esters was modified by complexation with iron tricarbonyl in order to evaluate their potential use as linker systems for solid phase chemistry. The best results were obtained with the tetrallnorophenolester, which was slowly cleaved when 1 equiv of amine was used, but could be rapidly cleaved with up to 94% yield when the amount of nucleophile was increased. (c) 2005 Elsevier Ltd. All rights reserved.

Author

Jonas Eriksson

Chalmers, Chemical and Biological Engineering, Organic Chemistry

T. Olsson

AstraZeneca AB

Nina Kann

Chalmers, Chemical and Biological Engineering, Organic Chemistry

Henrik Gradén

Chalmers, Chemical and Biological Engineering, Organic Chemistry

Tetrahedron Letters

0040-4039 (ISSN)

Vol. 47 5 635-638

Subject Categories

Chemical Sciences

DOI

10.1016/j.tetlet.2005.11.132

More information

Latest update

3/21/2018