Solid supported active esters as linkers: modification of reactivity using iron carbonyl complexes
Artikel i vetenskaplig tidskrift, 2006

The reactivity of three polymer-bound cyclohexadienoic acid active esters was modified by complexation with iron tricarbonyl in order to evaluate their potential use as linker systems for solid phase chemistry. The best results were obtained with the tetrallnorophenolester, which was slowly cleaved when 1 equiv of amine was used, but could be rapidly cleaved with up to 94% yield when the amount of nucleophile was increased. (c) 2005 Elsevier Ltd. All rights reserved.

Författare

Jonas Eriksson

Chalmers, Kemi- och bioteknik, Organisk kemi

T. Olsson

AstraZeneca AB

Nina Kann

Chalmers, Kemi- och bioteknik, Organisk kemi

Henrik Gradén

Chalmers, Kemi- och bioteknik, Organisk kemi

Tetrahedron Letters

0040-4039 (ISSN)

Vol. 47 5 635-638

Ämneskategorier

Kemi

DOI

10.1016/j.tetlet.2005.11.132