Combining traditional dietary assessment methods with novel metabolomics techniques: Present efforts by the Food Biomarker Alliance
Journal article, 2017
FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food intake biomarker research and highlights present research efforts of the Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (JPI-HDHL) Food Biomarkers Alliance (FoodBAll). In order to identify novel food intake biomarkers, the focus is on new food metabolomics techniques that allow the quantification of up to thousands of metabolites simultaneously, which may be applied in intervention and observational studies. As biomarkers are often influenced by various other factors than the food under investigation, FoodBAll developed a food intake biomarker quality and validity score aiming to assist the systematic evaluation of novel biomarkers. Moreover, to evaluate the applicability of nutritional biomarkers, studies are presently also focusing on associations between food intake biomarkers and diet-related disease risk. In order to be successful in these metabolomics studies, knowledge about available electronic metabolomics resources is necessary and further developments of these resources are essential. Ultimately, present efforts in this research area aim to advance quality control of traditional dietary assessment methods, advance compliance evaluation in nutritional intervention studies, and increase the significance of observational studies by investigating associations between nutrition and health.
Metabolomics
Food metabolome
Dietary assessment
Food intake biomarkers
Author
Elske M. Brouwer-Brolsma
Wageningen University and Research
Lorraine Brennan
University College Dublin
Christian A. Drevon
University of Oslo
Henk Van Kranen
Netherlands National Institute for Public Health and the Environment
Claudine Manach
Clermont Auvergne University
Lars Ove Dragsted
University of Copenhagen
Helen M. Roche
University College Dublin
Cristina Andres-Lacueva
University of Barcelona
Institute of Health Carlos III
Stephan J.L. Bakker
University of Groningen
J. Bouwman
Netherlands Organisation for Applied Scientific Research (TNO)
Francesco Capozzi
University of Bologna
Sarah De Saeger
Ghent university
Thomas E. Gundersen
Vitas Analytical Services
Marjukka Kolehmainen
University of Eastern Finland
Sabine E. Kulling
Max Rubner-Institut, Germany
Rikard Landberg
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Jakob Linseisen
Helmholtz
Fulvio Mattivi
Istituto Agrario San Michele all'Adige
Ronald P. Mensink
University Hospital Maastricht
Cristina Scaccini
Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agrari (CREA)
Thomas Skurk
Technical University of Munich
Inge Tetens
Technical University of Denmark (DTU)
Guy Vergeres
Forschungsanstalt Agroscope Changins-Wadenswil
David S. Wishart
University of Alberta
Augustin Scalbert
International Agency for Research on Cancer (IARC)
Edith J.M. Feskens
Wageningen University and Research
Proceedings of the Nutrition Society
0029-6651 (ISSN) 1475-2719 (eISSN)
Vol. 76 4 619-627Subject Categories
Food Science
Environmental Health and Occupational Health
Nutrition and Dietetics
DOI
10.1017/S0029665117003949
PubMed
29137687