Serum lipophilic antioxidants levels are associated with leucocyte telomere length among US adults
Journal article, 2018

Background: To examine the association between serum concentrations of antioxidant and telomere length (TL) in U.S adults. Methods: Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on TL measures from 2001 to 2002 were included. Serum lipophilic antioxidants level was measured using high performance liquid chromatography with photodiode array detection. We used analysis of co-variance and multivariable-adjusted linear regression models, accounting for the survey design and sample weights. Results: Of the 5992 eligible participants, 47.5% (n = 2844) were men. The mean age was 46.9 years overall, 47.2 years in men and 46.6 in women (p = 0.071). In age, sex, race, education, marital status, adiposity, smoking, C-reactive protein adjusted linear regressions, antioxidant, serum α-carotene, trans-β-carotene, cis- β-carotene, β-cryptoxanthin and combined Lutein/zeaxanthin were positively and significantly associated with TL (all p < 0.001). Conclusions: Our findings support a possible positive association between serum concentrations of lipophylic antioxidant and TL. The implications of this association deserve further investigation.

National health and nutrition examination survey

Telomere length



Mohsen Mazidi

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Andre Pascal Kengne

University of Cape Town

L. J. Cheskin

Johns Hopkins University

Maciej Banach

Polish Mother’s Memorial Hospital Research Institute

Medical University of Lodz

University of Zielona Góra

Lipids in Health and Disease

1476511x (eISSN)

Vol. 17 1 164

Subject Categories


Gerontology, specialising in Medical and Health Sciences

Public Health, Global Health, Social Medicine and Epidemiology



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