Serum lipophilic antioxidants levels are associated with leucocyte telomere length among US adults
Artikel i vetenskaplig tidskrift, 2018

Background: To examine the association between serum concentrations of antioxidant and telomere length (TL) in U.S adults. Methods: Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on TL measures from 2001 to 2002 were included. Serum lipophilic antioxidants level was measured using high performance liquid chromatography with photodiode array detection. We used analysis of co-variance and multivariable-adjusted linear regression models, accounting for the survey design and sample weights. Results: Of the 5992 eligible participants, 47.5% (n = 2844) were men. The mean age was 46.9 years overall, 47.2 years in men and 46.6 in women (p = 0.071). In age, sex, race, education, marital status, adiposity, smoking, C-reactive protein adjusted linear regressions, antioxidant, serum α-carotene, trans-β-carotene, cis- β-carotene, β-cryptoxanthin and combined Lutein/zeaxanthin were positively and significantly associated with TL (all p < 0.001). Conclusions: Our findings support a possible positive association between serum concentrations of lipophylic antioxidant and TL. The implications of this association deserve further investigation.

National health and nutrition examination survey

Telomere length



Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Andre Pascal Kengne

University of Cape Town

L. J. Cheskin

Johns Hopkins University

Maciej Banach

Instytut Centrum Zdrowia Matki Polki

Medical University of Lodz

Uniwersytet Zielonogorski

Lipids in Health and Disease

1476511x (eISSN)

Vol. 17 1 164



Gerontologi, medicinsk/hälsovetenskaplig inriktning

Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi



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