Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta-analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls
Journal article, 2018
Phytoestrogens may influence prostate cancer development. This study aimed to examine the association between prediagnostic circulating concentrations of isoflavones (genistein, daidzein, equol) and lignans (enterolactone and enterodiol) and the risk of prostate cancer. Individual participant data were available from seven prospective studies (two studies from Japan with 241 cases and 503 controls and five studies from Europe with 2,828 cases and 5,593 controls). Because of the large difference in circulating isoflavone concentrations between Japan and Europe, analyses of the associations of isoflavone concentrations and prostate cancer risk were evaluated separately. Prostate cancer risk by study-specific fourths of circulating concentrations of each phytoestrogen was estimated using multivariable-adjusted conditional logistic regression. In men from Japan, those with high compared to low circulating equol concentrations had a lower risk of prostate cancer (multivariable-adjusted OR for upper quartile [Q4] vs. Q1 = 0.61, 95% confidence interval [CI] = 0.39–0.97), although there was no significant trend (OR per 75 percentile increase = 0.69, 95 CI = 0.46–1.05, ptrend = 0.085); Genistein and daidzein concentrations were not significantly associated with risk (ORs for Q4 vs. Q1 = 0.70, 0.45–1.10 and 0.71, 0.45–1.12, respectively). In men from Europe, circulating concentrations of genistein, daidzein and equol were not associated with risk. Circulating lignan concentrations were not associated with the risk of prostate cancer, overall or by disease aggressiveness or time to diagnosis. There was no strong evidence that prediagnostic circulating concentrations of isoflavones or lignans are associated with prostate cancer risk, although further research is warranted in populations where isoflavone intakes are high.
isoflavones
pooled analysis
prostate cancer risk
lignans
phytoestrogens
Author
Aurora Perez-Cornago
University of Oxford
Paul N. Appleby
University of Oxford
Heiner Boeing
German Institute of Human Nutrition
Leire Gil
Public Health Division of Gipuzkoa-BIODONOSTIA
CIBER in Epidemiology and Public Health (CIBERESP)
C. Kyro
Danish Cancer Research Society Center
Fulvio Ricceri
Regional Health Service ASL TO3
University of Turin
Neil Murphy
International Agency for Research on Cancer (IARC)
Antonia Trichopoulou
Hellenic Health Foundation, Athens
Konstantinos K. Tsilidis
University of Ioannina
Imperial College London
Kay Tee Khaw
University of Cambridge
Robert N. Luben
University of Cambridge
Randi E. Gislefoss
Cancer Registry of Norway Institute of Population-Based Cancer Research
Hilde Langseth
Cancer Registry of Norway Institute of Population-Based Cancer Research
Isabel Drake
Lund University
Emily Sonestedt
Lund University
Peter Wallström
Skåne University Hospital
Lund University
Pär Stattin
Uppsala University
A. Johansson
Umeå University
Rikard Landberg
Umeå University
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Lena Nilsson
Umeå University
Kotaro Ozasa
Radiation Effects Research Foundation Hiroshima
Akiko Tamakoshi
Hokkaido University
Kazuya Mikami
Kyoto Prefectural University of Medicine
Tatsuhiko Kubo
University of Occupational and Environmental Health
Norie Sawada
National Cancer Center Tokyo
Shoichiro Tsugane
National Cancer Center Tokyo
Timothy J. Key
University of Oxford
Naomi E. Allen
University of Oxford
Ruth C. Travis
University of Oxford
International Journal of Cancer
0020-7136 (ISSN) 1097-0215 (eISSN)
Vol. 143 11 2677-2686Subject Categories
Urology and Nephrology
Cancer and Oncology
DOI
10.1002/ijc.31640
PubMed
29971774