New insights towards mesoporous silica nanoparticles as a technological platform for chemotherapeutic drugs delivery
Review article, 2019

Mesoporous silica nanoparticles (MSNs)displays interesting properties for biomedical applications such as high chemical stability, large surface area and tunable pores diameters and volumes, allowing the incorporation of large amounts of drugs, protecting them from deactivation and degradation processes acting as an excellent nanoplatform for drug delivery. However, the functional MSNs do not present the ability to transport the therapeutics without any leakage until reach the targeted cells causing side effects. On the other hand, the hydroxyls groups available on MSNs surface allows the conjugation of specific molecules which can binds to the overexpressed Enhanced Growth Factor Receptor (EGFR)in many tumors, representing a potential strategy for the cancer treatment. Beyond that, the targeting molecules conjugate onto mesoporous surface increase its cell internalization and act as gatekeepers blocking the mesopores controlling the drug release. In this context, multifunctional MSNs emerge as stimuli-responsive controlled drug delivery systems (CDDS)to overcome drawbacks as low internalization, premature release before to reach the region of interest, several side effects and low effectiveness of the current treatments. This review presents an overview of MSNs fabrication methods and its properties that affects drug delivery as well as stimuli-responsive CDDS for cancer treatment.

Stimuli-responsive nanoplatforms

Drug delivery

Chemotherapy drugs

Mesoporous silica nanoparticles

Cancer

Author

Rafael M. Sábio

University of Sao Paulo (USP)

Andréia B. Meneguin

University of Sao Paulo (USP)

Taís C. Ribeiro

São Paulo State University (UNESP)

Robson Rosa Da Silva

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Kasper Moth-Poulsen Group

Marlus Chorilli

São Paulo State University (UNESP)

International Journal of Pharmaceutics

0378-5173 (ISSN)

Vol. 564 379-409

Subject Categories

Pharmaceutical Sciences

Pharmacology and Toxicology

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

DOI

10.1016/j.ijpharm.2019.04.067

PubMed

31028801

More information

Latest update

5/20/2019