New insights towards mesoporous silica nanoparticles as a technological platform for chemotherapeutic drugs delivery
Reviewartikel, 2019

Mesoporous silica nanoparticles (MSNs)displays interesting properties for biomedical applications such as high chemical stability, large surface area and tunable pores diameters and volumes, allowing the incorporation of large amounts of drugs, protecting them from deactivation and degradation processes acting as an excellent nanoplatform for drug delivery. However, the functional MSNs do not present the ability to transport the therapeutics without any leakage until reach the targeted cells causing side effects. On the other hand, the hydroxyls groups available on MSNs surface allows the conjugation of specific molecules which can binds to the overexpressed Enhanced Growth Factor Receptor (EGFR)in many tumors, representing a potential strategy for the cancer treatment. Beyond that, the targeting molecules conjugate onto mesoporous surface increase its cell internalization and act as gatekeepers blocking the mesopores controlling the drug release. In this context, multifunctional MSNs emerge as stimuli-responsive controlled drug delivery systems (CDDS)to overcome drawbacks as low internalization, premature release before to reach the region of interest, several side effects and low effectiveness of the current treatments. This review presents an overview of MSNs fabrication methods and its properties that affects drug delivery as well as stimuli-responsive CDDS for cancer treatment.

Stimuli-responsive nanoplatforms

Drug delivery

Chemotherapy drugs

Mesoporous silica nanoparticles

Cancer

Författare

Rafael M. Sábio

Universidade de Sao Paulo (USP)

Andréia B. Meneguin

Universidade de Sao Paulo (USP)

Taís C. Ribeiro

Universidade Estadual Paulista (UNESP)

Robson Rosa Da Silva

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Kasper Moth-Poulsen Group

Marlus Chorilli

Universidade Estadual Paulista (UNESP)

International Journal of Pharmaceutics

0378-5173 (ISSN)

Vol. 564 379-409

Ämneskategorier

Farmaceutisk vetenskap

Farmakologi och toxikologi

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

DOI

10.1016/j.ijpharm.2019.04.067

PubMed

31028801

Mer information

Senast uppdaterat

2019-05-20