Investigation of central versus peripheral effects of estradiol in ovariectomized mice
Journal article, 2005
It is generally believed that estrogens exert their bone sparing effects directly on the cells within the bone compartment. The aim of the present study was to investigate if central mechanisms might be involved in the bone sparing effect of estrogens. The dose-response of central (i.c.v) 17beta-estradiol (E2) administration was compared with that of peripheral (s.c.) administration in ovariectomized (ovx) mice. The dose-response curves for central and peripheral E2 administration did not differ for any of the studied estrogen-responsive tissues, indicating that these effects were mainly peripheral. In addition, ovx mice were treated with E2 and/or the peripheral estrogen receptor antagonist ICI 182,780. ICI 182,780 attenuated most of the estrogenic response regarding uterus weight, retroperitoneal fat weight, cortical BMC and trabecular bone mineral content (P<0.05). These findings support the notion that the primary target tissue that mediates the effect of E2 on bone is peripheral and not central.
Drug Implants
Female
Dose-Response Relationship
Estradiol/*administration & dosage/analogs & derivatives/pharmacology
Humans
Femur/drug effects/physiopathology
Animal
Mice
Inbred C57BL
Osteoporosis
Tomography
Brain/*drug effects
Ovariectomy
Tibia/drug effects/physiopathology
Postmenopausal/*metabolism/physiopathology
Models
Drug
Estrogen Antagonists/pharmacology
Animals
Mice
Middle Aged
X-Ray Computed
Bone and Bones/*drug effects
Bone Density
Author
Niklas Andersson
University of Gothenburg
Ulrika Islander
University of Gothenburg
Emil Egecioglu
University of Gothenburg
Elin Löf
University of Gothenburg
Charlotte Swanson
University of Gothenburg
Sofia Movérare-Skrtic
University of Gothenburg
Klara Sjögren
University of Gothenburg
Marie Lindberg
University of Gothenburg
Catharina Lindholm
University of Gothenburg
Claes Ohlsson
University of Gothenburg
Journal of Endocrinology
0022-0795 (ISSN) 14796805 (eISSN)
Vol. 187 2 303-9Subject Categories (SSIF 2011)
MEDICAL AND HEALTH SCIENCES
DOI
10.1677/joe.1.06181
PubMed
16293778