Investigation of central versus peripheral effects of estradiol in ovariectomized mice
Artikel i vetenskaplig tidskrift, 2005
It is generally believed that estrogens exert their bone sparing effects directly on the cells within the bone compartment. The aim of the present study was to investigate if central mechanisms might be involved in the bone sparing effect of estrogens. The dose-response of central (i.c.v) 17beta-estradiol (E2) administration was compared with that of peripheral (s.c.) administration in ovariectomized (ovx) mice. The dose-response curves for central and peripheral E2 administration did not differ for any of the studied estrogen-responsive tissues, indicating that these effects were mainly peripheral. In addition, ovx mice were treated with E2 and/or the peripheral estrogen receptor antagonist ICI 182,780. ICI 182,780 attenuated most of the estrogenic response regarding uterus weight, retroperitoneal fat weight, cortical BMC and trabecular bone mineral content (P<0.05). These findings support the notion that the primary target tissue that mediates the effect of E2 on bone is peripheral and not central.
Femur/drug effects/physiopathology
Inbred C57BL
Mice
Animal
Drug
Tibia/drug effects/physiopathology
Tomography
Postmenopausal/*metabolism/physiopathology
Middle Aged
Estrogen Antagonists/pharmacology
Models
Female
Estradiol/*administration & dosage/analogs & derivatives/pharmacology
Dose-Response Relationship
Drug Implants
Animals
X-Ray Computed
Bone and Bones/*drug effects
Ovariectomy
Mice
Humans
Brain/*drug effects
Bone Density
Osteoporosis
Författare
Niklas Andersson
Göteborgs universitet
Ulrika Islander
Göteborgs universitet
Emil Egecioglu
Göteborgs universitet
Elin Löf
Göteborgs universitet
Charlotte Swanson
Göteborgs universitet
Sofia Movérare-Skrtic
Göteborgs universitet
Klara Sjögren
Göteborgs universitet
Marie Lindberg
Göteborgs universitet
Catharina Lindholm
Göteborgs universitet
Claes Ohlsson
Göteborgs universitet
Journal of Endocrinology
0022-0795 (ISSN) 14796805 (eISSN)
Vol. 187 2 303-9Ämneskategorier
MEDICIN OCH HÄLSOVETENSKAP
DOI
10.1677/joe.1.06181
PubMed
16293778