Investigation of central versus peripheral effects of estradiol in ovariectomized mice
Artikel i vetenskaplig tidskrift, 2005

It is generally believed that estrogens exert their bone sparing effects directly on the cells within the bone compartment. The aim of the present study was to investigate if central mechanisms might be involved in the bone sparing effect of estrogens. The dose-response of central (i.c.v) 17beta-estradiol (E2) administration was compared with that of peripheral (s.c.) administration in ovariectomized (ovx) mice. The dose-response curves for central and peripheral E2 administration did not differ for any of the studied estrogen-responsive tissues, indicating that these effects were mainly peripheral. In addition, ovx mice were treated with E2 and/or the peripheral estrogen receptor antagonist ICI 182,780. ICI 182,780 attenuated most of the estrogenic response regarding uterus weight, retroperitoneal fat weight, cortical BMC and trabecular bone mineral content (P<0.05). These findings support the notion that the primary target tissue that mediates the effect of E2 on bone is peripheral and not central.

Femur/drug effects/physiopathology

Inbred C57BL

Mice

Animal

Drug

Tibia/drug effects/physiopathology

Tomography

Postmenopausal/*metabolism/physiopathology

Middle Aged

Estrogen Antagonists/pharmacology

Models

Female

Estradiol/*administration & dosage/analogs & derivatives/pharmacology

Dose-Response Relationship

Drug Implants

Animals

X-Ray Computed

Bone and Bones/*drug effects

Ovariectomy

Mice

Humans

Brain/*drug effects

Bone Density

Osteoporosis

Författare

Niklas Andersson

Göteborgs universitet

Ulrika Islander

Göteborgs universitet

Emil Egecioglu

Göteborgs universitet

Elin Löf

Göteborgs universitet

Charlotte Swanson

Göteborgs universitet

Sofia Movérare-Skrtic

Göteborgs universitet

Klara Sjögren

Göteborgs universitet

Marie Lindberg

Göteborgs universitet

Catharina Lindholm

Göteborgs universitet

Claes Ohlsson

Göteborgs universitet

Journal of Endocrinology

0022-0795 (ISSN)

Vol. 187 303-9

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1677/joe.1.06181

PubMed

16293778