Styrene maleic acid copolymer induces pores in biomembranes
Journal article, 2019
We investigated the interactions between styrene–maleic acid (SMA) copolymers and phospholipid bilayers, using confocal microscopy and surface acoustic wave resonance (SAR) sensing. For the first time we experimentally observed and followed pore formation by SMA copolymers in intact supported bilayers and unilamellar vesicles, showing that fluorescein, a water-soluble organic compound with a mean diameter of 6.9 Å, can traverse the membrane. Our findings are in agreement with recent theoretical predictions, which suggested that SMA copolymers may insert along the plane of the bilayer to form stable toroidal pores.
Author
Marcella Orwick Rydmark
University of Oslo
Mikkel Killingmoe Christensen
University of Oslo
Elif Senem Köksal
University of Oslo
Ilayda Kantarci
University of Oslo
Kiryl Kustanovich
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Ventsislav Mitkov Yanchev
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Aldo Jesorka
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Irep Gözen
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
University of Oslo
Soft Matter
1744-683X (ISSN) 1744-6848 (eISSN)
Vol. 15 39 7934-7944Subject Categories
Polymer Chemistry
Physical Chemistry
Biocatalysis and Enzyme Technology
DOI
10.1039/c9sm01407a
PubMed
31539004