Styrene maleic acid copolymer induces pores in biomembranes
Journal article, 2019

We investigated the interactions between styrene–maleic acid (SMA) copolymers and phospholipid bilayers, using confocal microscopy and surface acoustic wave resonance (SAR) sensing. For the first time we experimentally observed and followed pore formation by SMA copolymers in intact supported bilayers and unilamellar vesicles, showing that fluorescein, a water-soluble organic compound with a mean diameter of 6.9 Å, can traverse the membrane. Our findings are in agreement with recent theoretical predictions, which suggested that SMA copolymers may insert along the plane of the bilayer to form stable toroidal pores.

Author

Marcella Orwick Rydmark

University of Oslo

Mikkel Killingmoe Christensen

University of Oslo

Elif Senem Köksal

University of Oslo

Ilayda Kantarci

University of Oslo

Kiryl Kustanovich

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Ventsislav Mitkov Yanchev

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Aldo Jesorka

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Irep Gözen

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

University of Oslo

Soft Matter

1744-683X (ISSN) 1744-6848 (eISSN)

Vol. 15 39 7934-7944

Subject Categories

Polymer Chemistry

Physical Chemistry

Biocatalysis and Enzyme Technology

DOI

10.1039/c9sm01407a

PubMed

31539004

More information

Latest update

11/11/2019