Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer
Journal article, 2020

Copper is involved in different hallmarks of cancer, including metastasis, but responsible copper-binding proteins and pathways are not clear. The copper chaperone ATOX1 was recently shown to play a role in breast cancer cell migration, which is a key step in metastasis. Since most cancer-related deaths are due to metastasis, we hypothesized that ATOX1 mRNA expression may be associated with breast cancer disease progression and thus, a prognostic biomarker in breast cancer. We therefore studied the association of ATOX1 expression levels with clinicopathological parameters and survival for 1904 breast cancer patients using the METABRIC data set. Our results indicate ATOX1 expression levels as a potential prognostic biomarker for ER-positive subtypes and early stages of breast cancer. Pre-clinical studies and clinical trials are desired to identify the molecular roles of ATOX1 in these conditions.

Biomarker

METABRIC

Survival

ATOX1

Breast cancer

Prognostic

Author

Stephanie Blockhuys

Chalmers, Biology and Biological Engineering, Chemical Biology

Donita C. Brady

University of Pennsylvania

Pernilla Wittung Stafshede

Chalmers, Biology and Biological Engineering, Chemical Biology

Breast Cancer

1340-6868 (ISSN)

Vol. in press

Subject Categories

Pathobiology

Urology and Nephrology

Cancer and Oncology

DOI

10.1007/s12282-019-01044-4

PubMed

31898157

More information

Latest update

4/14/2020