Pernilla Wittung Stafshede
Avdelningschef at
Chalmers, Biology and Biological Engineering, Chemical Biology
Pernilla Wittung-Stafshede is since 2015 professor and head of the Chemical Biology division in the Biology and Biological Engineering department. She leads a research group that focuses on metalloprotein mechanisms and protein misfolding. Pernilla has spent 12 years as a professor in the United States (at Tulane and Rice universities) followed by 7 years at Umeå University before she joined Chalmers faculty. She has published over 200 peer-reviewed papers (June, 2017).
Source: chalmers.se
Projects
2017–2018
Spegelvänd bioteknik med spegelvända enzymer
Pernilla Wittung Stafshede
Chemical Biology
Swedish Research Council (VR)
2013–2017
Female Investigators in Nonlinear Optical Nanoscopy - FINON (FINON)
Pernilla Wittung Stafshede
Chemical Biology
Alexandra Paul
Molecular Imaging
Michael Stuhrenberg
Molecular Imaging
European Commission (FP7)
2015–2017
Early structural transformations that promote Parkinson's disease
Pernilla Wittung Stafshede
Chemical Biology
The Parkinson Foundation in Sweden
2017–2018
Molekylära samspel mellan metalljoner och proteiner vid Parkinsons sjukdom
Pernilla Wittung Stafshede
Chemical Biology
Stiftelsen Olle Engkvist Byggmästare
2016–2020
Mekanismer för kopparjontransport i mänskliga celler
Pernilla Wittung Stafshede
Chemical Biology
Swedish Research Council (VR)
There might be more projects where Pernilla Wittung Stafshede participates, but you have to be logged in as a Chalmers employee to see them.
Publications
2017
Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast
Kumaravel Ponnandai Shanmugavel, Dina Petranovic, Pernilla Wittung-Stafshede et al
Metallomics. Vol. 9 (7), p. 981-988
Scientific journal article - peer reviewed
2017
Cross-Reactivity of Alpha-Synuclein with Other Cellular Components Can Dramatically Modulate Amyloid Formation
Pernilla Wittung-Stafshede,
Biophysical Journal. Vol. 112 (3), p. 365A-365A
Scientific journal article - non peer reviewed
2017
Roles of copper-binding proteins in breast cancer
Stephanie Blockhuys, Pernilla Wittung-Stafshede,
International Journal of Molecular Sciences. Vol. 18 (4), p. Article no 871
Scientific journal article - peer reviewed
2017
Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles
Juris Kiskis, Istvan Horvath, Pernilla Wittung-Stafshede et al
Quarterly Reviews of Biophysics. Vol. 50, p. 1-9
Scientific journal article - peer reviewed
2017
Copper chaperone Atox1 plays role in breast cancer cell migration
Stephanie Blockhuys, Pernilla Wittung-Stafshede,
Biochemical and Biophysical Research Communications - BBRC. Vol. 483 (1), p. 301-304
Scientific journal article - peer reviewed
2017
Defining the human copper proteome and analysis of its expression variation in cancers.
Stephanie Blockhuys, Emanuele Celauro, C Hildesjö et al
Metallomics. Vol. 9 (2), p. 112-123
Scientific journal article - peer reviewed
2016
Unravelling amyloid formation paths triggered by anionic vesicles of Parkinson’s disease protein, α-synuclein
Juris Kiskis, Istvan Horvath, Pernilla Wittung-Stafshede et al
Quarterly Reviews of Biophysics
Scientific journal article - peer reviewed
2016
gästbloggare
Pernilla Wittung-Stafshede,
Curie Vetenskapsrådets webb tidning
Journal article - popular science
2016
Is the gender gap solved in liberal Sweden?
Pernilla Wittung-Stafshede,
stemwomen.net
Journal article - popular science
2016
Akademin is Sverige är ej så jämställd som du tror.
Pernilla Wittung-Stafshede,
Curie Vetenskapsrådets webb tidning
Journal article - popular science
2016
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.
Timothy R Sampson, Justine W Debelius, Taren Thron et al
Cell. Vol. 167 (6), p. 1469-1480.e12
Scientific journal article - peer reviewed
2016
Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.
Ranjeet Kumar, Candan Ariöz, Yaozong Li et al
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Scientific journal article - peer reviewed
2016
A Copper Story: From Protein Folding and Metal Transport to Cancer
Pernilla Wittung-Stafshede,
Israel Journal of Chemistry. Vol. 56 (9-10), p. 671-681
Scientific journal article - peer reviewed
2016
Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease
Istvan Horvath, Pernilla Wittung-Stafshede,
Proceedings of the National Academy of Sciences of the United States of America. Vol. 113 (44), p. 12473-12477
Scientific journal article - peer reviewed
2016
Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA
James A D Good, Christopher Andersson, Sabine Hansen et al
Cell Chemical Biology. Vol. 23 (3), p. 404-414
Scientific journal article - peer reviewed
2016
Protein Interactions that Enable Safe and Efficient Copper Ion Transport in the Human Cytoplasm
Pernilla Wittung-Stafshede,
Biophysical Journal. Vol. 110 (3), p. 179A-179A
Scientific journal article - peer reviewed
2016
Extended functional repertoire for human copper chaperones
Maria Matson Dzebo, Candan Ariöz, Pernilla Wittung-Stafshede et al
Biomolecular Concepts. Vol. 7 (1), p. 29-39
Scientific journal article - peer reviewed
2016
The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1
D. Kahra, M. Kovermann, Pernilla Wittung-Stafshede et al
Biophysical Journal. Vol. 110 (1), p. 95-102
Scientific journal article - peer reviewed
2016
Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B
T. Mondol, J. Aden, Pernilla Wittung-Stafshede et al
Biochemical and Biophysical Research Communications. Vol. 470 (3), p. 663-669
Scientific journal article - peer reviewed
2015
Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice
M. Chermenina, E. Chorell, M. Pokrzywa et al
Parkinson's Disease. Vol. 1
Scientific journal article - peer reviewed
2015
Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.
Sandeep K Sharma, Erik Chorell, Pernilla Wittung-Stafshede et al
Biochemical and biophysical research communications. Vol. 466 (2), p. 192-5
Scientific journal article - peer reviewed
2015
Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.
Erik Chorell, Emma Andersson, Margery L Evans et al
PloS one. Vol. 10 (10), p. e0140194
Scientific journal article - peer reviewed
2015
Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?
Helena Öhrvik, Pernilla Wittung-Stafshede,
International journal of molecular sciences. Vol. 16 (8), p. 16728-39
Scientific journal article - peer reviewed
2015
Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.
Sandeep K Sharma, Erik Chorell, Pär Steneberg et al
Scientific reports. Vol. 5, p. 12531
Scientific journal article - peer reviewed
2015
Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.
Dana Kahra, Tanumoy Mondol, Moritz S Niemiec et al
Protein and peptide letters. Vol. 22 (6), p. 532-8
Scientific journal article - peer reviewed
2015
Enthalpy-entropy compensation at play in human copper ion transfer.
Moritz S Niemiec, Artur P G Dingeldein, Pernilla Wittung-Stafshede et al
Scientific reports. Vol. 5, p. 10518
Scientific journal article - peer reviewed
2015
Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.
Martin Nors Perdersen, Vito Foderà, Istvan Horvath et al
Scientific reports. Vol. 5, p. 10422
Scientific journal article - peer reviewed
2015
Unresolved questions in human copper pump mechanisms.
Pernilla Wittung-Stafshede,
Quarterly reviews of biophysics. Vol. 48 (4), p. 471-8
Scientific journal article - peer reviewed
2015
Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.
Svenja Petzoldt, Dana Kahra, Michael Kovermann et al
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. Vol. 28 (3), p. 577-85
Scientific journal article - peer reviewed
2015
The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.
Margery L Evans, Erik Chorell, Jonathan D Taylor et al
Molecular cell. Vol. 57 (3), p. 445-55
Scientific journal article - peer reviewed
2015
Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation
P. Singh, E. Chorell, K.S. Krishnan et al
Organic Letters. Vol. 17 (24), p. 6194-6197
Scientific journal article - peer reviewed
2011
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.
Maria E Palm, Christoph F Weise, Christina Lundin et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 108 (17), p. 6951-6
Scientific journal article - peer reviewed
1999
Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties
G. Haaima, H. Rasmussen, G. Schmidt et al
New Journal of Chemistry. Vol. 23 (8), p. 833-840
Scientific journal article - peer reviewed
1999
Peptide nucleic acids
Bengt Nordén, Pernilla Wittung-Stafshede,
The Encyclopedia of Molecular Biology (ed. Thomas E.Creighton), p. 1801-1808
Chapter in monograph, book
1999
The L2 Loop Peptide of recA Stiffens and restricts Base Motions of Single-stranded DNA Similar to Intact Protein
T. Selmane, Pernilla Wittung-Stafshede, F. Maraboeuf et al
FEBS Letters. Vol. 446 (1), p. 30-34
Scientific journal article - peer reviewed
1998
Base Orientation of Second DNA in RecA-DNA Filaments. Analysis by combination of linear dichroism and small angle neutron scattering in flow-oriented solution
Bengt Nordén, Pernilla Wittung-Stafshede, C. Ellouze et al
Journal of Biological Chemistry. Vol. 273 (25), p. 15682-15686
Scientific journal article - peer reviewed