Pernilla Wittung Stafshede

2020

Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer

2020

Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein

Amyloid formation of fish β-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers

Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration

Correlation between Cellular Uptake and Cytotoxicity of Fragmented α-Synuclein Amyloid Fibrils Suggests Intracellular Basis for Toxicity

2020

Differential effects of Cu2+ and Fe3+ ions on in vitro amyloid formation of biologically-relevant α-synuclein variants

2020

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Role of Zero-Order Loop in Protein Unfolding Case Study with Apoazurin

2020

Female Faculty: Why So Few and Why Care?

2020

Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro

2020

The Caenorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell migration

Mirror-Image 5S Ribonucleoprotein Complexes

2020

Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease

Copper relay path through the N-terminus of Wilson disease protein, ATP7B

Membrane-protein-hydration interaction of alpha-synuclein with anionic vesicles in solution probed via angle-resolved second harmonic scattering

Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

2019

My journey in academia: Things not on the CV

Crowding-Induced Elongated Conformation of Urea-Unfolded Apoazurin: Investigating the Role of Crowder Shape in Silico

Synaptic vesicle mimics affect the aggregation of wild-type and A53T α-synuclein variants differently albeit similar membrane affinity

Interaction between Copper Chaperone Atox1 and Parkinson's Disease Protein α-Synuclein Includes Metal-Binding Sites and Occurs in Living Cells

Wilson disease missense mutations in ATP7B affect metal-binding domain structural dynamics

Membrane-Protein-Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

2018

Copper Chaperone Atox1 Interacts with Cell Cycle Proteins

Folding of copper proteins: Role of the metal?

2018

Abundant fish protein inhibits α-synuclein amyloid formation

2018

Copper chaperone blocks amyloid formation via ternary complex

Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells

The processes of α-synuclein amyloid protein complexes involved in the pathogenesis of Parkinson’s disease

2018

Alpha-Synuclein Modulates the Physical Properties of DNA

Geometrical Description of Protein Structural Motifs

In vitro analysis of α-synuclein amyloid formation and cross-reactivity

2018

Synergistic effects of copper sites on apparent stability of multicopper oxidase, Fet3p

3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets

A Luminal Loop of Wilson Disease Protein Binds Copper and Is Required for Protein Activity

Copper distribution in breast cancer cells detected by time-of-flight secondary ion mass spectrometry with delayed extraction methodology

The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations

2017

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease

2017

Copper chaperone Atox1 plays role in breast cancer cell migration

2017

Roles of copper-binding proteins in breast cancer

2017

Defining the human copper proteome and analysis of its expression variation in cancers.

2017

Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation

Cross-Reactivity of Alpha-Synuclein with Other Cellular Components Can Dramatically Modulate Amyloid Formation

2017

Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast

Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.

A stretched conformation of DNA with a biological role?

2017

Second harmonic generation for collagen I characterization in rectal cancer patients with and without preoperative radiotherapy

Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos

2017

Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.

Extended functional repertoire for human copper chaperones

A Copper Story: From Protein Folding and Metal Transport to Cancer

Akademin is Sverige är ej så jämställd som du tror.

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA

Protein Interactions that Enable Safe and Efficient Copper Ion Transport in the Human Cytoplasm

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease

2016

The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1

Is the gender gap solved in liberal Sweden?

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Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B

Enthalpy-entropy compensation at play in human copper ion transfer.

The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.

Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.

Unresolved questions in human copper pump mechanisms.

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.

Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation

Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.

The L2 Loop Peptide of recA Stiffens and restricts Base Motions of Single-stranded DNA Similar to Intact Protein

Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties

Peptide nucleic acids

Base Orientation of Second DNA in RecA-DNA Filaments. Analysis by combination of linear dichroism and small angle neutron scattering in flow-oriented solution

Recognition of Double-Stranded DNA by Peptide Nucleic Acids

Observation of a PNA-PNA-PNA triplex

Thermochemical and kinetic evidence for nucleotide-sequence-dependent RecA-DNA interactions

Extended DNA-Recognition Repertoire of Peptide Nucleic Acid (PNA): PNA-dsDNA triplex formed with cytosine-rich homopyrimidine PNA

Peptide nucleic acids with a conformationally constrained chiral cyclohexyl-derived backbone

Ionic effects on the stability and conformation of peptide nucleic acid complexes

Second-site RecA - DNA interactions: Lack of identical recognition

Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA

Direct observation of strand invasion by peptide nucleic acid (PNA) into double-stranded DNA

Functional interactions of nucleic acids : in simple DNA analogs and recombinase intermediates

Secondary Structure of RecA in Solution - The Effects of Cofactor, DNA and Ionic Conditions

Fluorescence-detected interactions of oligonucleotides in RecA complexes

Induced Chirality in PNA-PNA Duplexes

Evidence for Elongation of the Helical Pitch of the RecA Filament Upon ATP and ADP Binding Using Small-Angle Neutron Scattering

PNA-Peptide Chimerae

Phospholipid membrane permeability of peptide nucleic acid

INTERACTIONS BETWEEN DNA-MOLECULES BOUND TO RECA FILAMENT - EFFECTS OF BASE COMPLEMENTARITY

INTERACTIONS OF DNA-BINDING LIGANDS WITH PNA DNA HYBRIDS

DNA-LIKE DOUBLE HELIX FORMED BY PEPTIDE NUCLEIC-ACID

STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA

SPECTROSCOPIC OBSERVATION OF RENATURATION BETWEEN POLYNUCLEOTIDES INTERACTING WITH RECA IN THE PRESENCE OF ATP HYDROLYSIS