Pernilla Wittung Stafshede

Full Professor at Chemical Biology

Pernilla Wittung-Stafshede is since 2015 professor (division head 2015-2018) at the Chemical Biology division in the Biology and Biological Engineering department. She leads a research group that focuses on metalloprotein mechanisms (e.g., in cancer) and protein misfolding (e.g. in Parkinson's disease). Pernilla has spent 12 years as a professor in the United States (at Tulane and Rice universities) followed by 7 years at UmeƄ University before she joined Chalmers faculty. She has published over 260 peer-reviewed papers (2022) and many popular texts. Since january 2019, Pernilla is the Head of Genie, Gender Initiative for Excellence, which is a huge 10-year initiative financed by the Foundation in order to improve gender equality among Chalmers faculty.






Source: chalmers.se
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Showing 124 publications

2024

Yoga als Komplementärtherapie für Krebspatienten: Von klinischen Beobachtungen bis zu biochemischen Mechanismen

Stephanie Blockhuys, Pernilla Wittung Stafshede
Complementary medicine research. Vol. 31 (5), p. 403-415
Review article
2024

Copper ion incorporation in α-synuclein amyloids

Gulshan Rameshrao Walke, Ranjeet Kumar, Pernilla Wittung Stafshede
Protein Science. Vol. 33 (4)
Journal article
2023

Distinct growth regimes of α-synuclein amyloid elongation

Istvan Horvath, Hannah Welte, Jeremy D. Schmit et al
Biophysical Journal. Vol. 122 (12), p. 2556-2563
Journal article
2023

Chemical catalysis by biological amyloids

Pernilla Wittung Stafshede
Biochemical Society Transactions. Vol. 51 (5), p. 1967-1974
Review article
2023

Comparing lipid remodeling of brown adipose tissue, white adipose tissue, and liver after one-week high fat diet intervention with quantitative Raman microscopy

Alexandra Paul, Belén Chanclón, Cecilia Brännmark et al
Journal of Cellular Biochemistry. Vol. 124 (3), p. 382-395
Journal article
2023

Memo1 reduces copper-mediated reactive oxygen species in breast cancer cells

Xiaolu Zhang, Gulshan Rameshrao Walke, Pernilla Wittung Stafshede
Journal of Inorganic Biochemistry. Vol. 247
Journal article
2023

Amyloids of α-Synuclein Promote Chemical Transformations of Neuronal Cell Metabolites

Istvan Horvath, Khadra A. Mohamed, Ranjeet Kumar et al
International Journal of Molecular Sciences. Vol. 24 (16)
Journal article
2023

Amyloid Fibers of α-Synuclein Catalyze Chemical Reactions

Istvan Horvath, Pernilla Wittung Stafshede
ACS Chemical Neuroscience. Vol. 14 (4), p. 603-608
Journal article
2022

Crossroads between copper ions and amyloid formation in Parkinson's disease

Pernilla Wittung Stafshede
Essays in biochemistry. Vol. 66 (7), p. 977-986
Review article
2022

Frustration Dynamics and Electron-Transfer Reorganization Energies in Wild-Type and Mutant Azurins

Xun Chen, Mingchen Chen, Peter G. Wolynes et al
Journal of the American Chemical Society. Vol. 144 (9), p. 4178-4185
Journal article
2022

Gut power: Modulation of human amyloid formation by amyloidogenic proteins in the gastrointestinal tract

Pernilla Wittung Stafshede
Current Opinion in Structural Biology. Vol. 72, p. 33-38
Review article
2022

Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro

Xiaolu Zhang, Gulshan Rameshrao Walke, Istvan Horvath et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 119 (37), p. e2206905119-
Journal article
2021

Response to crowded conditions reveals compact nucleus for amyloid formation of folded protein

Tony Werner, Istvan Horvath, Pernilla Wittung Stafshede
QRB Discovery. Vol. 2
Journal article
2021

Another pearl in the “copper-transport” necklace

Pernilla Wittung Stafshede
Biophysical Journal. Vol. 120 (20), p. 4305-4306
Journal article
2021

C-terminal truncation of α-synuclein alters DNA structure from extension to compaction

Kai Jiang, Sandra Rocha, Ranjeet Kumar et al
Biochemical and Biophysical Research Communications. Vol. 568, p. 43-47
Journal article
2021

Macromolecular crowding modulates α-synuclein amyloid fiber growth

Istvan Horvath, Ranjeet Kumar, Pernilla Wittung Stafshede
Biophysical Journal. Vol. 120 (16), p. 3374-3381
Journal article
2021

Atp7a-regulated enzyme metalation and trafficking in the menkes disease puzzle

Nina Horn, Pernilla Wittung Stafshede
Biomedicines. Vol. 9 (4)
Review article
2021

A large ‘discovery’ experiment: Gender Initiative for Excellence (Genie) at Chalmers University of Technology

Maria Saline, Mary Sheeran, Pernilla Wittung Stafshede
QRB Discovery. Vol. 2
Review article
2021

The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation

Michael Grasso, Gavin J. Bond, Ye Jin Kim et al
Journal of Biological Chemistry. Vol. 297 (6)
Journal article
2021

Impact of crowded environments on binding between protein and single-stranded DNA

Birgit Köhn, Patricia Schwarz, Pernilla Wittung Stafshede et al
Scientific Reports. Vol. 11 (1)
Journal article
2021

Effects of the toxic metals arsenite and cadmium on α-synuclein aggregation in vitro and in cells

Emma Lorentzon, Istvan Horvath, Ranjeet Kumar et al
International Journal of Molecular Sciences. Vol. 22 (21)
Journal article
2021

Ska vi verkligen ge Astra Zenecas vaccin till äldre?

Bengt Nordén, Pernilla Wittung Stafshede
Göteborgs-Posten (GP)
Newspaper article
2021

Orientation of α-Synuclein at Negatively Charged Lipid Vesicles: Linear Dichroism Reveals Time-Dependent Changes in Helix Binding Mode

Sandra Rocha, Ranjeet Kumar, Bengt Nordén et al
Journal of the American Chemical Society. Vol. 143 (45), p. 18899-18906
Journal article
2021

The Zero-Order Loop in Apoazurin Modulates Folding Mechanism In Silico

Fabio C. Zegarra, Dirar Homouz, Pernilla Wittung Stafshede et al
Journal of Physical Chemistry B. Vol. 125 (14), p. 3501-3509
Journal article
2020

Differential effects of Cu2+ and Fe3+ ions on in vitro amyloid formation of biologically-relevant α-synuclein variants

Emma Lorentzon, Ranjeet Kumar, Istvan Horvath et al
Biometals. Vol. 33 (2-3), p. 97-106
Journal article
2020

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Timothy R. Sampson, Collin Challis, Neha Jain et al
eLife. Vol. 9
Journal article
2020

Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease

Tony Werner, Istvan Horvath, Pernilla Wittung Stafshede
Journal of Parkinsons Disease. Vol. 10 (3), p. 819-830
Review article
2020

Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein

Jonas Hannestad, Sandra Rocha, Björn Agnarsson et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (25), p. 14178-14186
Journal article
2020

Correlation between Cellular Uptake and Cytotoxicity of Fragmented α-Synuclein Amyloid Fibrils Suggests Intracellular Basis for Toxicity

Xiaolu Zhang, Emelie Vilhelmsson Wesén, Ranjeet Kumar et al
ACS Chemical Neuroscience. Vol. 11 (3), p. 233-241
Journal article
2020

Role of Zero-Order Loop in Protein Unfolding Case Study with Apoazurin

Dirar M. Homouz, Fabio Zegarra, Pernilla Wittung Stafshede et al
Biophysical Journal. Vol. 118 (3, Supplement 1), p. 197A-197A
Paper in proceeding
2020

Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration

Stephanie Blockhuys, Xiaolu Zhang, Pernilla Wittung Stafshede
Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (4), p. 2014-2019
Journal article
2020

My journey in academia: Things not on the CV

Pernilla Wittung Stafshede
Pure and Applied Chemistry. Vol. 92 (5), p. 789-796
Journal article
2020

Female Faculty: Why So Few and Why Care?

Shina Caroline Lynn Kamerlin, Pernilla Wittung Stafshede
Chemistry - A European Journal. Vol. 26 (38), p. 8319-8323
Other text in scientific journal
2020

Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro

Nima Sasanian, David Bernson, Istvan Horvath et al
Biomolecules. Vol. 10 (6), p. 1-19
Journal article
2020

The Caenorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell migration

Xiaolu Zhang, Stephanie Blockhuys, Ranjan Devkota et al
Biometals. Vol. 33 (2-3), p. 147-157
Journal article
2020

Amyloid formation of fish β-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers

Tony Werner, David Bernson, Elin Esbjörner Winters et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (45), p. 27997-28004
Journal article
2020

Mirror-Image 5S Ribonucleoprotein Complexes

Jun-Jie Ling, Chuyao Fan, Hong Qin et al
Angewandte Chemie - International Edition. Vol. 59 (9), p. 3724-3731
Journal article
2020

Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer

Stephanie Blockhuys, Donita C. Brady, Pernilla Wittung Stafshede
Breast Cancer. Vol. 27 (3), p. 505-509
Journal article
2019

Wilson disease missense mutations in ATP7B affect metal-binding domain structural dynamics

Kumaravel Ponnandai Schanmugavel, Ranjeet Kumar, Yaozong Li et al
Biometals. Vol. 32 (6), p. 875-885
Journal article
2019

Membrane-Protein-Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

Jan Dedic, Sandra Rocha, Halil I. Okur et al
Journal of Physical Chemistry B. Vol. 123 (5), p. 1044-1049
Journal article
2019

Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Kai Jiang, Sandra Rocha, Alvina Westling et al
Biophysical Journal
Paper in proceeding
2019

Crowding-Induced Elongated Conformation of Urea-Unfolded Apoazurin: Investigating the Role of Crowder Shape in Silico

Fabio C. Zegarra, Dirar Homouz, Andrei G. Gasic et al
Journal of Physical Chemistry B. Vol. 123 (17), p. 3607-3617
Journal article
2019

Synaptic vesicle mimics affect the aggregation of wild-type and A53T α-synuclein variants differently albeit similar membrane affinity

Sandra Rocha, Ranjeet Kumar, Istvan Horvath et al
Protein engineering, design & selection : PEDS. Vol. 32 (2), p. 59-66
Journal article
2019

Copper relay path through the N-terminus of Wilson disease protein, ATP7B

Kumaravel Ponnandai Schanmugavel, Pernilla Wittung Stafshede
Metallomics. Vol. 11 (9), p. 1472-1480
Journal article
2019

Interaction between Copper Chaperone Atox1 and Parkinson's Disease Protein α-Synuclein Includes Metal-Binding Sites and Occurs in Living Cells

Istvan Horvath, Stephanie Blockhuys, Darius Šulskis et al
ACS Chemical Neuroscience. Vol. 10 (11), p. 4659-4668
Journal article
2018

Alpha-Synuclein Modulates the Physical Properties of DNA

Kai Jiang, Sandra Rocha, Alvina Westling et al
Chemistry - A European Journal. Vol. 24 (58), p. 15685-15690
Journal article
2018

Folding of copper proteins: Role of the metal?

Candan Ariöz, Pernilla Wittung Stafshede
Quarterly Reviews of Biophysics. Vol. 51
Review article
2018

Geometrical Description of Protein Structural Motifs

John J. Kozak, Harry B. Gray, Pernilla Wittung Stafshede
Journal of Physical Chemistry B. Vol. 122 (49), p. 11289-11294
Journal article
2018

Abundant fish protein inhibits α-synuclein amyloid formation

Tony Werner, Ranjeet Kumar, Istvan Horvath et al
Scientific Reports. Vol. 8 (1)
Journal article
2018

Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells

Amberlyn M. Wands, Jakob Cervin, He Huang et al
ACS Infectious Diseases. Vol. 4 (5), p. 758-770
Journal article
2018

Copper Chaperone Atox1 Interacts with Cell Cycle Proteins

Maria Matson Dzebo, Stephanie Blockhuys, Sebastian Valenzuela et al
Computational and Structural Biotechnology Journal. Vol. 16, p. 443-449
Journal article
2018

3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets

Diana Ribeiro, Alexander J. Kvist, Pernilla Wittung Stafshede et al
Stem Cell Reviews and Reports. Vol. 14 (2), p. 177-188
Review article
2018

In vitro analysis of α-synuclein amyloid formation and cross-reactivity

Istvan Horvath, Sandra Rocha, Pernilla Wittung Stafshede
Methods in Molecular Biology. Vol. 1779, p. 73-83
Book chapter
2018

Synergistic effects of copper sites on apparent stability of multicopper oxidase, Fet3p

Erik Sedlák, Gabriel Žoldák, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 19 (1)
Journal article
2018

Copper chaperone blocks amyloid formation via ternary complex

Istvan Horvath, Tony Werner, Ranjeet Kumar et al
Quarterly Reviews of Biophysics. Vol. 51, p. e6-e6
Journal article
2018

The processes of α-synuclein amyloid protein complexes involved in the pathogenesis of Parkinson’s disease

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. Vol. 118 (8), p. 75-81
Journal article
2018

A Luminal Loop of Wilson Disease Protein Binds Copper and Is Required for Protein Activity

Birgit Köhn, Kumaravel Ponnandai Schanmugavel, Min Wu et al
Biophysical Journal. Vol. 115 (6), p. 1007-1018
Journal article
2018

Copper distribution in breast cancer cells detected by time-of-flight secondary ion mass spectrometry with delayed extraction methodology

Stephanie Blockhuys, Per Malmberg, Pernilla Wittung Stafshede
Biointerphases. Vol. 13 (6)
Journal article
2017

The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations

Candan Ariöz, Y. Z. Li, Pernilla Wittung Stafshede
Biometals. Vol. 30 (6), p. 823-840
Journal article
2017

Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos

Emanuele Celauro, Amisa Mukaj, Juan Carlos Fierro González et al
Biochemical and Biophysical Research Communications. Vol. 491 (1), p. 147-153
Journal article
2017

Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation

Diana Ribeiro, Istvan Horvath, N. Heath et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 114 (42), p. 11127-11132
Journal article
2017

Roles of copper-binding proteins in breast cancer

Stephanie Blockhuys, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 18 (4)
Review article
2017

Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Quarterly Reviews of Biophysics. Vol. 50, p. 1-9
Journal article
2017

Defining the human copper proteome and analysis of its expression variation in cancers.

Stephanie Blockhuys, Emanuele Celauro, C. Hildesjo et al
Metallomics. Vol. 9 (2), p. 112-123
Journal article
2017

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease

M. Pokrzywa, K. Pawelek, W. E. Kucia et al
PLoS ONE. Vol. 12 (9), p. Aet no e0184117-
Journal article
2017

Cross-Reactivity of Alpha-Synuclein with Other Cellular Components Can Dramatically Modulate Amyloid Formation

Pernilla Wittung Stafshede
Biophysical Journal. Vol. 112 (3), p. 365A-365A
Magazine article
2017

Copper chaperone Atox1 plays role in breast cancer cell migration

Stephanie Blockhuys, Pernilla Wittung Stafshede
Biochemical and Biophysical Research Communications. Vol. 483 (1), p. 301-304
Journal article
2017

A stretched conformation of DNA with a biological role?

Niklas Bosaeus, Anna Reymer, Tamas Beke-Somfai et al
Quarterly Reviews of Biophysics. Vol. 50, p. UNSP e11-e11
Journal article
2017

Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast

Kumaravel Ponnandai Schanmugavel, Dina Petranovic Nielsen, Pernilla Wittung Stafshede
Metallomics. Vol. 9 (7), p. 981-988
Journal article
2017

Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics

Ranjeet Kumar, Candan Ariöz, Yaozong Li et al
Biometals. Vol. 30 (1), p. 27-35
Journal article
2017

Second harmonic generation for collagen I characterization in rectal cancer patients with and without preoperative radiotherapy

Stephanie Blockhuys, Nisha Rani Agarwal, C. Hildesjo et al
Journal of Biomedical Optics. Vol. 22 (10)
Journal article
2016

The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1

D. Kahra, M. Kovermann, Pernilla Wittung Stafshede
Biophysical Journal. Vol. 110 (1), p. 95-102
Journal article
2016

A Copper Story: From Protein Folding and Metal Transport to Cancer

Pernilla Wittung Stafshede
Israel Journal of Chemistry. Vol. 56 (9-10), p. 671-681
Review article
2016

gästbloggare

Pernilla Wittung Stafshede
Curie Vetenskapsrådets webb tidning
Magazine article
2016

Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B

T. Mondol, J. Åden, Pernilla Wittung Stafshede
Biochemical and Biophysical Research Communications. Vol. 470 (3), p. 663-669
Journal article
2016

Protein Interactions that Enable Safe and Efficient Copper Ion Transport in the Human Cytoplasm

Pernilla Wittung Stafshede
Biophysical Journal. Vol. 110 (3), p. 179A-179A
Journal article
2016

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA

James A D Good, Christopher Andersson, Sabine Hansen et al
Cell Chemical Biology. Vol. 23 (3), p. 404-414
Journal article
2016

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.

Timothy R Sampson, Justine W Debelius, Taren Thron et al
Cell. Vol. 167 (6), p. 1469-1480.e12
Journal article
2016

Is the gender gap solved in liberal Sweden?

Pernilla Wittung Stafshede
stemwomen.net
Magazine article
2016

Akademin is Sverige är ej så jämställd som du tror.

Pernilla Wittung Stafshede
Curie Vetenskapsrådets webb tidning
Magazine article
2016

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease

Istvan Horvath, Pernilla Wittung Stafshede
Proceedings of the National Academy of Sciences of the United States of America. Vol. 113 (44), p. 12473-12477
Journal article
2016

Extended functional repertoire for human copper chaperones

Maria Matson Dzebo, Candan Ariöz, Pernilla Wittung Stafshede
Biomolecular Concepts. Vol. 7 (1), p. 29-39
Journal article
2015

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.

E. Chorell, Emma Andersson, Margery L Evans et al
PLoS ONE. Vol. 10 (10), p. e0140194-
Journal article
2015

Enthalpy-entropy compensation at play in human copper ion transfer.

Moritz S Niemiec, Artur P G Dingeldein, Pernilla Wittung Stafshede
Scientific Reports. Vol. 5, p. 10518-
Journal article
2015

Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation

P. Singh, E. Chorell, K.S. Krishnan et al
Organic Letters. Vol. 17 (24), p. 6194-6197
Journal article
2015

Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?

Helena Öhrvik, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 16 (8), p. 16728-39
Journal article
2015

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Martin Nors Perdersen, Vito Foderà, Istvan Horvath et al
Scientific Reports. Vol. 5, p. 10422-
Journal article
2015

The bacterial curli system possesses a potent and selective inhibitor of amyloid formation

Margery L Evans, E. Chorell, Jonathan D Taylor et al
Molecular Cell. Vol. 57 (3), p. 445-455
Journal article
2015

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.

Svenja Petzoldt, Dana Kahra, Michael Kovermann et al
Biometals. Vol. 28 (3), p. 577-85
Journal article
2015

Unresolved questions in human copper pump mechanisms.

Pernilla Wittung Stafshede
Quarterly Reviews of Biophysics. Vol. 48 (4), p. 471-8
Journal article
2015

Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.

Dana Kahra, Tanumoy Mondol, Moritz S Niemiec et al
Protein and peptide letters. Vol. 22 (6), p. 532-8
Journal article
2015

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.

Sandeep K Sharma, E. Chorell, Pernilla Wittung Stafshede
Biochemical and Biophysical Research Communications. Vol. 466 (2), p. 192-5
Journal article
2015

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.

Sandeep K Sharma, E. Chorell, Pär Steneberg et al
Scientific Reports. Vol. 5, p. 12531-
Journal article
2015

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

M. Chermenina, E. Chorell, M. Pokrzywa et al
Parkinsons Disease. Vol. 1
Journal article
2011

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.

Maria E Palm, Christoph F Weise, Christina Lundin et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 108 (17), p. 6951-6
Journal article
2000

Detection of point mutations in DNA by PNA-based quartz-crystal biosensor

Pernilla Wittung Stafshede, Michael Rodahl, Bengt Herbert Kasemo et al
Colloids and Surfaces A: Physicochemical and Engineering Aspects. Vol. 174 (1-2), p. 269-273
Journal article
1999

Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties

G. Haaima, H. Rasmussen, G. Schmidt et al
New Journal of Chemistry. Vol. 23 (8), p. 833-840
Journal article
1999

Peptide nucleic acids

Bengt Nordén, Pernilla Wittung Stafshede
The Encyclopedia of Molecular Biology (ed. Thomas E.Creighton), p. 1801-1808
Book chapter
1999

In vitro membrane penetration of modified peptide nucleic acid (PNA)

Malin Ardhammar, Bengt Nordén, P.E. Nielsen et al
Journal of Biomolecular Structure and Dynamics. Vol. 17 (1), p. 33-40
Journal article
1999

The L2 Loop Peptide of recA Stiffens and restricts Base Motions of Single-stranded DNA Similar to Intact Protein

T. Selmane, Pernilla Wittung Stafshede, F. Maraboeuf et al
FEBS Letters. Vol. 446 (1), p. 30-34
Journal article
1998

Base Orientation of Second DNA in RecA-DNA Filaments. Analysis by combination of linear dichroism and small angle neutron scattering in flow-oriented solution

Bengt Nordén, Pernilla Wittung Stafshede, C. Ellouze et al
Journal of Biological Chemistry. Vol. 273 (25), p. 15682-15686
Journal article
1997

Extended DNA-Recognition Repertoire of Peptide Nucleic Acid (PNA): PNA-dsDNA triplex formed with cytosine-rich homopyrimidine PNA

Pernilla Wittung, P. Nielsen, Bengt Nordén
Biochemistry. Vol. 36 (26), p. 7973-7979
Journal article
1997

Recognition of Double-Stranded DNA by Peptide Nucleic Acids

Pernilla Wittung, P. Nielsen, Bengt Nordén
Nucleosides and Nucleotides. Vol. 16 (5-6), p. 599-602
Journal article
1997

Observation of a PNA-PNA-PNA triplex

Pernilla Wittung, P. Nielsen, Bengt Nordén
Journal of the American Chemical Society. Vol. 119 (13), p. 3189-3190
Journal article
1997

Peptide nucleic acids with a conformationally constrained chiral cyclohexyl-derived backbone

P. Lagriffoule, Pernilla Wittung, M. Eriksson et al
Chemistry - A European Journal. Vol. 3 (6), p. 912-919
Journal article
1997

Thermochemical and kinetic evidence for nucleotide-sequence-dependent RecA-DNA interactions

Pernilla Wittung, C. Ellouze, F. Maraboeuf et al
European Journal of Biochemistry. Vol. 245 (3), p. 715-719
Journal article
1996

Second-site RecA - DNA interactions: Lack of identical recognition

Pernilla Wittung, L. R. Bazemore, M. Takahashi et al
Biochemistry. Vol. 35 (48), p. 15349-15355
Journal article
1996

Direct observation of strand invasion by peptide nucleic acid (PNA) into double-stranded DNA

Pernilla Wittung, P. Nielsen, Bengt Nordén
Journal of the American Chemical Society. Vol. 118 (30), p. 7049-7054
Journal article
1996

Ionic effects on the stability and conformation of peptide nucleic acid complexes

S. Tomac, M. Sarkar, Tommi Ratilainen et al
Journal of the American Chemical Society. Vol. 118 (24), p. 5544-5552
Journal article
1995

Induced Chirality in PNA-PNA Duplexes

Pernilla Wittung, M. Eriksson, Reidar Lyng et al
Journal of the American Chemical Society. Vol. 117 (41), p. 10167-10173
Journal article
1995

Phospholipid membrane permeability of peptide nucleic acid

Pernilla Wittung, Johan Kajanus, K. Edwards et al
FEBS Letters. Vol. 365 (1), p. 27-29
Journal article
1995

Fluorescence-detected interactions of oligonucleotides in RecA complexes

Pernilla Wittung, M. Funk, B. Jernstrom et al
FEBS Letters. Vol. 368 (1), p. 64-68
Journal article
1995

Evidence for Elongation of the Helical Pitch of the RecA Filament Upon ATP and ADP Binding Using Small-Angle Neutron Scattering

C. Ellouze, M. Takahashi, Pernilla Wittung et al
European Journal of Biochemistry. Vol. 233 (2), p. 579-583
Journal article
1995

PNA-Peptide Chimerae

T. Koch, M. Naesby, Pernilla Wittung et al
Tetrahedron Letters. Vol. 36 (38), p. 6933-6936
Journal article
1995

Secondary Structure of RecA in Solution - The Effects of Cofactor, DNA and Ionic Conditions

Pernilla Wittung, Bengt Nordén, M. Takahashi
European Journal of Biochemistry. Vol. 228 (1), p. 149-154
Journal article
1994

DNA-LIKE DOUBLE HELIX FORMED BY PEPTIDE NUCLEIC-ACID

Pernilla Wittung, P. E. Nielsen, O. Buchardt et al
Nature. Vol. 368 (6471), p. 561-563
Journal article
1994

INTERACTIONS OF DNA-BINDING LIGANDS WITH PNA DNA HYBRIDS

Pernilla Wittung, S. K. Kim, O. Buchardt et al
Nucleic Acids Research. Vol. 22 (24), p. 5371-5377
Journal article
1994

SPECTROSCOPIC OBSERVATION OF RENATURATION BETWEEN POLYNUCLEOTIDES INTERACTING WITH RECA IN THE PRESENCE OF ATP HYDROLYSIS

Pernilla Wittung, Bengt Nordén, M. Takahashi
European Journal of Biochemistry. Vol. 224 (1), p. 39-45
Journal article
1994

STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA

B. Hyrup, M. Egholm, P. E. Nielsen et al
Journal of the American Chemical Society. Vol. 116 (18), p. 7964-7970
Journal article
1994

INTERACTIONS BETWEEN DNA-MOLECULES BOUND TO RECA FILAMENT - EFFECTS OF BASE COMPLEMENTARITY

Pernilla Wittung, Bengt Nordén, S. K. Kim et al
Journal of Biological Chemistry. Vol. 269 (8), p. 5799-5803
Journal article

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Showing 15 research projects

2024–2027

Catalytic activity of alpha-synuclein amyloid fibers

Pernilla Wittung Stafshede Chemical Biology
Swedish Research Council (VR)

2024–2026

Role of Copper Binding to oncogenic Memo1 in Breast Cancer Cells

Pernilla Wittung Stafshede Chemical Biology
Cancerfonden

2021–2023

Role of copper chaperone Atox1 in breast cancer metastasis

Pernilla Wittung Stafshede Chemical Biology
Cancerfonden

1 publication exists
2020–2024

Membrane Protein Structure Determination using Atom Probe Tomography

Martin Andersson Martin Andersson Group
Pernilla Wittung Stafshede Chemical Biology
Fredrik Höök Nano and Biophysics
Swedish Research Council (VR)

2 publications exist
2020–2021

Help a Scientist - subproject 2020 Starhunt

Jonathan Tan Galactic Astrophysics
Pernilla Wittung Stafshede Chemical Biology
Rubén Fedriani Galactic Astrophysics
Giuliana Cosentino Galactic Astrophysics
Swedish Foundation for Strategic Research (SSF)

2020–2024

Disease mechanisms of copper chaperone Atox1

Pernilla Wittung Stafshede Chemical Biology
Swedish Research Council (VR)

3 publications exist
2019–2021

Mechanism underlying the interaction of the Parkinson's disease protein, alpha-synuclein, with lipid membranes

Sandra Rocha Chemical Biology
Pernilla Wittung Stafshede Chemical Biology
Demensförbundet

2019–2028

Gender Initiative for Excellence (Genie)

Pernilla Wittung Stafshede Chemical Biology
Mary Sheeran Functional Programming
Anders Karlström Electrical Engineering
Thomas Nilsson Physics
Maria Saline Lednings- och utvecklingsstöd
Anna Grzelec Science, Technology and Society
The Chalmers University Foundation

12 publications exist
2018–2020

Kopparjoners roll vid spridning av cancer

Pernilla Wittung Stafshede Chemical Biology
Cancerfonden

1 publication exists
2017–2018

Combining nonlinear spectroscopy and stem cells to understand our "fat problem"

Pernilla Wittung Stafshede Chemical Biology
Stiftelsen Wilhelm och Martina Lundgrens Vetenskapsfond

2017–2018

Molekylära samspel mellan metalljoner och proteiner vid Parkinsons sjukdom

Pernilla Wittung Stafshede Chemical Biology
Stiftelsen Olle Engkvist Byggmästare

2017–2018

Spegelvänd bioteknik med spegelvända enzymer

Pernilla Wittung Stafshede Chemical Biology
Swedish Research Council (VR)

2016–2020

Mekanismer för kopparjontransport i mänskliga celler

Pernilla Wittung Stafshede Chemical Biology
Swedish Research Council (VR)

2 publications exist
2015–2017

Early structural transformations that promote Parkinson's disease

Pernilla Wittung Stafshede Chemical Biology
The Parkinson Foundation in Sweden

2013–2017

Female Investigators in Nonlinear Optical Nanoscopy - FINON (FINON)

Pernilla Wittung Stafshede Chemical Biology
Alexandra Paul Molecular Imaging
Michael Stuhrenberg Molecular Imaging
European Commission (EC)

2 publications exist
There might be more projects where Pernilla Wittung Stafshede participates, but you have to be logged in as a Chalmers employee to see them.