Pernilla Wittung Stafshede

Avdelningschef at Chalmers, Biology and Biological Engineering, Chemical Biology

Pernilla Wittung-Stafshede is since 2015 professor and head of the Chemical Biology division in the Biology and Biological Engineering department. She leads a research group that focuses on metalloprotein mechanisms and protein misfolding. Pernilla has spent 12 years as a professor in the United States (at Tulane and Rice universities) followed by 7 years at Umeå University before she joined Chalmers faculty. She has published over 200 peer-reviewed papers (June, 2017).

Source: chalmers.se

Projects

2017–2018

Spegelvänd bioteknik med spegelvända enzymer

Pernilla Wittung Stafshede Chemical Biology
Swedish Research Council (VR)

2013–2017

Female Investigators in Nonlinear Optical Nanoscopy - FINON (FINON)

Pernilla Wittung Stafshede Chemical Biology
Alexandra Paul Molecular Imaging
Michael Stuhrenberg Molecular Imaging
European Commission (FP7)

2015–2017

Early structural transformations that promote Parkinson's disease

Pernilla Wittung Stafshede Chemical Biology
The Parkinson Foundation in Sweden

2017–2018

Molekylära samspel mellan metalljoner och proteiner vid Parkinsons sjukdom

Pernilla Wittung Stafshede Chemical Biology
Stiftelsen Olle Engkvist Byggmästare

2016–2020

Mekanismer för kopparjontransport i mänskliga celler

Pernilla Wittung Stafshede Chemical Biology
Swedish Research Council (VR)

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Publications

2017

Roles of copper-binding proteins in breast cancer

Stephanie Blockhuys, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 18 (4), p. Article no 871-
Journal article
2017

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease

M. Pokrzywa, W. E. Kucia, K. Pawelek et al
PLoS ONE. Vol. 12 (9), p. Aet no e0184117-
Journal article
2017

Copper chaperone Atox1 plays role in breast cancer cell migration

Stephanie Blockhuys, Pernilla Wittung Stafshede
Biochemical and Biophysical Research Communications. Vol. 483 (1), p. 301-304
Journal article
2017

Cross-Reactivity of Alpha-Synuclein with Other Cellular Components Can Dramatically Modulate Amyloid Formation

Pernilla Wittung Stafshede
Biophysical Journal. Vol. 112 (3), p. 365A-365A
Scientific journal article - non peer reviewed
2017

Defining the human copper proteome and analysis of its expression variation in cancers.

Amir Feizi, C. Hildesjo, Stephanie Blockhuys et al
Metallomics. Vol. 9 (2), p. 112-123
Journal article
2017

Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast

Kumaravel Ponnandai Shanmugavel, Dina Petranovic Nielsen, Pernilla Wittung Stafshede
Metallomics. Vol. 9 (7), p. 981-988
Journal article
2017

A stretched conformation of DNA with a biological role?

Sandra Rocha, M. Takahashi, Anna Reymer et al
Quarterly Reviews of Biophysics. Vol. 50, p. UNSP e11-
Journal article
2017

Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos

Emanuele Celauro, Amisa Mukaj, Juan Carlos Fierro González et al
Biochemical and Biophysical Research Communications. Vol. 491 (1), p. 147-153
Journal article
2017

Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Quarterly Reviews of Biophysics. Vol. 50, p. 1-9
Journal article
2016

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.

Marie-Francoise Chesselet, Collin Challis, Timothy R Sampson et al
Cell. Vol. 167 (6), p. 1469-1480.e12
Journal article
2016

Extended functional repertoire for human copper chaperones

Candan Ariöz, Pernilla Wittung Stafshede, Maria Matson Dzebo
Biomolecular Concepts. Vol. 7 (1), p. 29-39
Journal article
2016

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA

A. Elisabeth Sauer-Eriksson, Christin Grundström, Christopher Andersson et al
Cell Chemical Biology. Vol. 23 (3), p. 404-414
Journal article
2016

A Copper Story: From Protein Folding and Metal Transport to Cancer

Pernilla Wittung Stafshede
Israel Journal of Chemistry. Vol. 56 (9-10), p. 671-681
Journal article
2016

Akademin is Sverige är ej så jämställd som du tror.

Pernilla Wittung Stafshede
Journal article - popular science
2016

Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.

Candan Ariöz, Yaozong Li, Sandra Rocha et al
Biometals (1), p. 27-35
Journal article
2016

Unravelling amyloid formation paths triggered by anionic vesicles of Parkinson’s disease protein, α-synuclein

Pernilla Wittung Stafshede, Sandra Rocha, Istvan Horvath et al
Quarterly Reviews of Biophysics
Journal article
2016

Protein Interactions that Enable Safe and Efficient Copper Ion Transport in the Human Cytoplasm

Pernilla Wittung Stafshede
Biophysical Journal. Vol. 110 (3), p. 179A-179A
Journal article
2016

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease

Pernilla Wittung Stafshede, Istvan Horvath
Proceedings of the National Academy of Sciences of the United States of America. Vol. 113 (44), p. 12473-12477
Journal article
2016

gästbloggare

Pernilla Wittung Stafshede
Journal article - popular science
2016

The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1

Pernilla Wittung Stafshede, M. Kovermann, D. Kahra
Biophysical Journal. Vol. 110 (1), p. 95-102
Journal article
2016

Is the gender gap solved in liberal Sweden?

Pernilla Wittung Stafshede
Journal article - popular science
2016

Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B

T. Mondol, Pernilla Wittung Stafshede, J. Åden
Biochemical and Biophysical Research Communications. Vol. 470 (3), p. 663-669
Journal article
2015

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.

Sandeep K Sharma, Pernilla Wittung Stafshede, Emma Vernersson-Lindahl et al
Scientific Reports. Vol. 5, p. 12531-
Journal article
2015

The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.

Steve J Matthews, Margery L Evans, Matthew R Chapman et al
Molecular Cell. Vol. 57 (3), p. 445-55
Journal article
2015

Enthalpy-entropy compensation at play in human copper ion transfer.

Moritz S Niemiec, Pernilla Wittung Stafshede, Artur P G Dingeldein
Scientific Reports. Vol. 5, p. 10518-
Journal article
2015

Unresolved questions in human copper pump mechanisms.

Pernilla Wittung Stafshede
Quarterly Reviews of Biophysics. Vol. 48 (4), p. 471-8
Journal article
2015

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.

Svenja Petzoldt, Dana Kahra, Artur P G Dingeldein et al
Biometals. Vol. 28 (3), p. 577-85
Journal article
2015

Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.

Tanumoy Mondol, Dana Kahra, Moritz S Niemiec et al
Protein and peptide letters. Vol. 22 (6), p. 532-8
Journal article
2015

Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation

T. Kindahl, P. Singh, J. Åden et al
Organic Letters. Vol. 17 (24), p. 6194-6197
Journal article
2015

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.

Anna Götheson, J. Åden, Neha Jain et al
PLoS ONE. Vol. 10 (10), p. e0140194-
Journal article
2015

Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?

Helena Öhrvik, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 16 (8), p. 16728-39
Journal article
2015

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

H. Antti, M. Chermenina, E. Chorell et al
Parkinsons Disease. Vol. 1
Journal article
2015

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.

Pernilla Wittung Stafshede, Sandeep K Sharma, E. Chorell
Biochemical and Biophysical Research Communications. Vol. 466 (2), p. 192-5
Journal article
2015

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Bente Vestergaard, Christoph Weise, Magnus Wolf-Watz et al
Scientific Reports. Vol. 5, p. 10422-
Journal article
2011

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.

Gunnar Wingsle, Pernilla Wittung Stafshede, Maria E Palm et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 108 (17), p. 6951-6
Journal article
1999

The L2 Loop Peptide of recA Stiffens and restricts Base Motions of Single-stranded DNA Similar to Intact Protein

T. Selmane, Bengt Nordén, M. Takahashi et al
FEBS Letters. Vol. 446 (1), p. 30-34
Journal article
1999

Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties

P.E. Nielsen, G. Haaima, G. Schmidt et al
New Journal of Chemistry. Vol. 23 (8), p. 833-840
Journal article
1999

Peptide nucleic acids

Bengt Nordén, Pernilla Wittung Stafshede
The Encyclopedia of Molecular Biology (ed. Thomas E.Creighton), p. 1801-1808
Chapter in monograph, book
1998

Base Orientation of Second DNA in RecA-DNA Filaments. Analysis by combination of linear dichroism and small angle neutron scattering in flow-oriented solution

Pernilla Wittung Stafshede, K. Mortensen, Hye-Kyung Kim et al
Journal of Biological Chemistry. Vol. 273 (25), p. 15682-15686
Journal article
1997

Observation of a PNA-PNA-PNA triplex

P. Nielsen, Bengt Nordén, Pernilla Wittung Stafshede
Journal of the American Chemical Society. Vol. 119 (13), p. 3189-3190
Journal article
1997

Thermochemical and kinetic evidence for nucleotide-sequence-dependent RecA-DNA interactions

Bengt Nordén, Pernilla Wittung Stafshede, C. Ellouze et al
European Journal of Biochemistry. Vol. 245 (3), p. 715-719
Journal article
1997

Recognition of Double-Stranded DNA by Peptide Nucleic Acids

P. Nielsen, Pernilla Wittung Stafshede, Bengt Nordén
Nucleosides and Nucleotides. Vol. 16 (5-6), p. 599-602
Journal article
1997

Extended DNA-Recognition Repertoire of Peptide Nucleic Acid (PNA): PNA-dsDNA triplex formed with cytosine-rich homopyrimidine PNA

Pernilla Wittung Stafshede, Bengt Nordén, P. Nielsen
Biochemistry. Vol. 36 (26), p. 7973-7979
Journal article
1997

Peptide nucleic acids with a conformationally constrained chiral cyclohexyl-derived backbone

M. Eriksson, P. Nielsen, Bengt Nordén et al
Chemistry - A European Journal. Vol. 3 (6), p. 912-919
Journal article
1996

Ionic effects on the stability and conformation of peptide nucleic acid complexes

P. E. Nielsen, M. Sarkar, Pernilla Wittung Stafshede et al
Journal of the American Chemical Society. Vol. 118 (24), p. 5544-5552
Journal article
1996

Second-site RecA - DNA interactions: Lack of identical recognition

C. Radding, Pernilla Wittung Stafshede, Bengt Nordén et al
Biochemistry. Vol. 35 (48), p. 15349-15355
Journal article
1996

Direct observation of strand invasion by peptide nucleic acid (PNA) into double-stranded DNA

Bengt Nordén, Pernilla Wittung Stafshede, P. Nielsen
Journal of the American Chemical Society. Vol. 118 (30), p. 7049-7054
Journal article
1995

Fluorescence-detected interactions of oligonucleotides in RecA complexes

Bengt Nordén, Pernilla Wittung Stafshede, M. Takahashi et al
FEBS Letters. Vol. 368 (1), p. 64-68
Journal article
1995

Secondary Structure of RecA in Solution - The Effects of Cofactor, DNA and Ionic Conditions

Pernilla Wittung Stafshede, Bengt Nordén, M. Takahashi
European Journal of Biochemistry. Vol. 228 (1), p. 149-154
Journal article
1995

Induced Chirality in PNA-PNA Duplexes

Bengt Nordén, P. E. Nielsen, Reidar Lyng et al
Journal of the American Chemical Society. Vol. 117 (41), p. 10167-10173
Journal article
1995

Evidence for Elongation of the Helical Pitch of the RecA Filament Upon ATP and ADP Binding Using Small-Angle Neutron Scattering

M. Takahashi, Bengt Nordén, M. Schnarr et al
European Journal of Biochemistry. Vol. 233 (2), p. 579-583
Journal article
1995

PNA-Peptide Chimerae

Pernilla Wittung Stafshede, Bengt Nordén, M. Jorgensen et al
Tetrahedron Letters. Vol. 36 (38), p. 6933-6936
Journal article
1995

Phospholipid membrane permeability of peptide nucleic acid

Bengt Nordén, K. Edwards, Pernilla Wittung Stafshede et al
FEBS Letters. Vol. 365 (1), p. 27-29
Journal article
1994

INTERACTIONS BETWEEN DNA-MOLECULES BOUND TO RECA FILAMENT - EFFECTS OF BASE COMPLEMENTARITY

Bengt Nordén, M. Takahashi, Pernilla Wittung Stafshede et al
Journal of Biological Chemistry. Vol. 269 (8), p. 5799-5803
Journal article
1994

INTERACTIONS OF DNA-BINDING LIGANDS WITH PNA DNA HYBRIDS

O. Buchardt, S. K. Kim, Pernilla Wittung Stafshede et al
Nucleic Acids Research. Vol. 22 (24), p. 5371-5377
Journal article
1994

DNA-LIKE DOUBLE HELIX FORMED BY PEPTIDE NUCLEIC-ACID

Pernilla Wittung Stafshede, M. Egholm, O. Buchardt et al
Nature. Vol. 368 (6471), p. 561-563
Journal article
1994

STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA

M. Egholm, O. Buchardt, P. E. Nielsen et al
Journal of the American Chemical Society. Vol. 116 (18), p. 7964-7970
Journal article
1994

SPECTROSCOPIC OBSERVATION OF RENATURATION BETWEEN POLYNUCLEOTIDES INTERACTING WITH RECA IN THE PRESENCE OF ATP HYDROLYSIS

Bengt Nordén, M. Takahashi, Pernilla Wittung Stafshede
European Journal of Biochemistry. Vol. 224 (1), p. 39-45
Journal article