Pernilla Wittung Stafshede

Avdelningschef at Chalmers, Biology and Biological Engineering, Chemical Biology

Pernilla Wittung-Stafshede is new professor and head of the Chemical Biology division in the recently created Biology and Biological Engineering department. She leads a research group that focuses on metalloprotein mechanisms and protein misfolding. Pernilla has spent 12 years as a professor in the United States (at Tulane and Rice universities) followed by 7 years at Umeå University. She has published over 190 peer-reviewed papers and her H-index is 37.

Source: chalmers.se

Projects

2017–2018

Spegelvänd bioteknik med spegelvända enzymer

Pernilla Wittung Stafshede Chemical Biology
Swedish Research Council (VR)

2013–2017

Female Investigators in Nonlinear Optical Nanoscopy - FINON (FINON)

Pernilla Wittung Stafshede Chemical Biology
Alexandra Paul Molecular Imaging
Michael Stuhrenberg Molecular Imaging
European Commission (FP7)

2015–2017

Early structural transformations that promote Parkinson's disease

Pernilla Wittung Stafshede Chemical Biology
The Parkinson Foundation in Sweden

2017–2018

Molekylära samspel mellan metalljoner och proteiner vid Parkinsons sjukdom

Pernilla Wittung Stafshede Chemical Biology
Stiftelsen Olle Engkvist Byggmästare

2016–2020

Mekanismer för kopparjontransport i mänskliga celler

Pernilla Wittung Stafshede Chemical Biology
Swedish Research Council (VR)

There might be more projects where Pernilla Wittung Stafshede participates, but you have to be logged in as a Chalmers employee to see them.

Publications

2017

Roles of copper-binding proteins in breast cancer

Stephanie Blockhuys, Pernilla Wittung-Stafshede,
International Journal of Molecular Sciences. Vol. 18 (4), p. Article no 871
Scientific journal article - peer reviewed
2017

Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles

Juris Kiskis, Istvan Horvath, Pernilla Wittung-Stafshede et al
Quarterly Reviews of Biophysics. Vol. 50, p. 1-9
Scientific journal article - peer reviewed
2017

Copper chaperone Atox1 plays role in breast cancer cell migration

Stephanie Blockhuys, Pernilla Wittung-Stafshede,
Biochemical and Biophysical Research Communications - BBRC. Vol. 483 (1), p. 301-304
Scientific journal article - peer reviewed
2017

Defining the human copper proteome and analysis of its expression variation in cancers.

Stephanie Blockhuys, Emanuele Celauro, C Hildesjö et al
Metallomics. Vol. 9 (2), p. 112-123
Scientific journal article - peer reviewed
2016

Unravelling amyloid formation paths triggered by anionic vesicles of Parkinson’s disease protein, α-synuclein

Juris Kiskis, Istvan Horvath, Pernilla Wittung-Stafshede et al
Quarterly Reviews of Biophysics
Scientific journal article - peer reviewed
2016

gästbloggare

Pernilla Wittung-Stafshede,
Curie Vetenskapsrådets webb tidning
Journal article - popular science
2016

Is the gender gap solved in liberal Sweden?

Pernilla Wittung-Stafshede,
stemwomen.net
Journal article - popular science
2016

Akademin is Sverige är ej så jämställd som du tror.

Pernilla Wittung-Stafshede,
Curie Vetenskapsrådets webb tidning
Journal article - popular science
2016

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.

Timothy R Sampson, Justine W Debelius, Taren Thron et al
Cell. Vol. 167 (6), p. 1469-1480.e12
Scientific journal article - peer reviewed
2016

Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.

Ranjeet Kumar, Candan Ariöz, Yaozong Li et al
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Scientific journal article - peer reviewed
2016

A Copper Story: From Protein Folding and Metal Transport to Cancer

Pernilla Wittung-Stafshede,
Israel Journal of Chemistry. Vol. 56 (9-10), p. 671-681
Scientific journal article - peer reviewed
2016

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease

Istvan Horvath, Pernilla Wittung-Stafshede,
Proceedings of the National Academy of Sciences of the United States of America. Vol. 113 (44), p. 12473-12477
Scientific journal article - peer reviewed
2016

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA

James A D Good, Christopher Andersson, Sabine Hansen et al
Cell Chemical Biology. Vol. 23 (3), p. 404-414
Scientific journal article - peer reviewed
2016

Protein Interactions that Enable Safe and Efficient Copper Ion Transport in the Human Cytoplasm

Pernilla Wittung-Stafshede,
Biophysical Journal. Vol. 110 (3), p. 179A-179A
Scientific journal article - peer reviewed
2016

Extended functional repertoire for human copper chaperones

Maria Matson Dzebo, Candan Ariöz, Pernilla Wittung-Stafshede et al
Biomolecular Concepts. Vol. 7 (1), p. 29-39
Scientific journal article - peer reviewed
2016

The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1

D. Kahra, M. Kovermann, Pernilla Wittung-Stafshede et al
Biophysical Journal. Vol. 110 (1), p. 95-102
Scientific journal article - peer reviewed
2016

Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B

T. Mondol, J. Aden, Pernilla Wittung-Stafshede et al
Biochemical and Biophysical Research Communications. Vol. 470 (3), p. 663-669
Scientific journal article - peer reviewed
2015

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

M. Chermenina, E. Chorell, M. Pokrzywa et al
Parkinson's Disease. Vol. 1
Scientific journal article - peer reviewed
2015

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.

Sandeep K Sharma, Erik Chorell, Pernilla Wittung-Stafshede et al
Biochemical and biophysical research communications. Vol. 466 (2), p. 192-5
Scientific journal article - peer reviewed
2015

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.

Erik Chorell, Emma Andersson, Margery L Evans et al
PloS one. Vol. 10 (10), p. e0140194
Scientific journal article - peer reviewed
2015

Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?

Helena Öhrvik, Pernilla Wittung-Stafshede,
International journal of molecular sciences. Vol. 16 (8), p. 16728-39
Scientific journal article - peer reviewed
2015

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.

Sandeep K Sharma, Erik Chorell, Pär Steneberg et al
Scientific reports. Vol. 5, p. 12531
Scientific journal article - peer reviewed
2015

Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.

Dana Kahra, Tanumoy Mondol, Moritz S Niemiec et al
Protein and peptide letters. Vol. 22 (6), p. 532-8
Scientific journal article - peer reviewed
2015

Enthalpy-entropy compensation at play in human copper ion transfer.

Moritz S Niemiec, Artur P G Dingeldein, Pernilla Wittung-Stafshede et al
Scientific reports. Vol. 5, p. 10518
Scientific journal article - peer reviewed
2015

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Martin Nors Perdersen, Vito Foderà, Istvan Horvath et al
Scientific reports. Vol. 5, p. 10422
Scientific journal article - peer reviewed
2015

Unresolved questions in human copper pump mechanisms.

Pernilla Wittung-Stafshede,
Quarterly reviews of biophysics. Vol. 48 (4), p. 471-8
Scientific journal article - peer reviewed
2015

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.

Svenja Petzoldt, Dana Kahra, Michael Kovermann et al
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. Vol. 28 (3), p. 577-85
Scientific journal article - peer reviewed
2015

The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.

Margery L Evans, Erik Chorell, Jonathan D Taylor et al
Molecular cell. Vol. 57 (3), p. 445-55
Scientific journal article - peer reviewed
2015

Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation

P. Singh, E. Chorell, K.S. Krishnan et al
Organic Letters. Vol. 17 (24), p. 6194-6197
Scientific journal article - peer reviewed
2011

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.

Maria E Palm, Christoph F Weise, Christina Lundin et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 108 (17), p. 6951-6
Scientific journal article - peer reviewed
1999

Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties

G. Haaima, H. Rasmussen, G. Schmidt et al
New Journal of Chemistry. Vol. 23 (8), p. 833-840
Scientific journal article - peer reviewed
1999

Peptide nucleic acids

Bengt Nordén, Pernilla Wittung-Stafshede,
The Encyclopedia of Molecular Biology (ed. Thomas E.Creighton), p. 1801-1808
Chapter in monograph, book
1999

The L2 Loop Peptide of recA Stiffens and restricts Base Motions of Single-stranded DNA Similar to Intact Protein

T. Selmane, Pernilla Wittung-Stafshede, F. Maraboeuf et al
FEBS Letters. Vol. 446 (1), p. 30-34
Scientific journal article - peer reviewed
1998

Base Orientation of Second DNA in RecA-DNA Filaments. Analysis by combination of linear dichroism and small angle neutron scattering in flow-oriented solution

Bengt Nordén, Pernilla Wittung-Stafshede, C. Ellouze et al
Journal of Biological Chemistry. Vol. 273 (25), p. 15682-15686
Scientific journal article - peer reviewed