Pernilla Wittung Stafshede
Avdelningschef at
Chalmers, Biology and Biological Engineering, Chemical Biology
Pernilla Wittung-Stafshede is since 2015 professor and head of the Chemical Biology division in the Biology and Biological Engineering department. She leads a research group that focuses on metalloprotein mechanisms and protein misfolding. Pernilla has spent 12 years as a professor in the United States (at Tulane and Rice universities) followed by 7 years at Umeå University before she joined Chalmers faculty. She has published over 200 peer-reviewed papers (June, 2017).
Source: chalmers.se
Projects
2017–2018
Spegelvänd bioteknik med spegelvända enzymer
Pernilla Wittung Stafshede
Chemical Biology
Swedish Research Council (VR)
2013–2017
Female Investigators in Nonlinear Optical Nanoscopy - FINON (FINON)
Pernilla Wittung Stafshede
Chemical Biology
Alexandra Paul
Molecular Imaging
Michael Stuhrenberg
Molecular Imaging
European Commission (FP7)
2015–2017
Early structural transformations that promote Parkinson's disease
Pernilla Wittung Stafshede
Chemical Biology
The Parkinson Foundation in Sweden
2017–2018
Molekylära samspel mellan metalljoner och proteiner vid Parkinsons sjukdom
Pernilla Wittung Stafshede
Chemical Biology
Stiftelsen Olle Engkvist Byggmästare
2016–2020
Mekanismer för kopparjontransport i mänskliga celler
Pernilla Wittung Stafshede
Chemical Biology
Swedish Research Council (VR)
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Publications
2017
Roles of copper-binding proteins in breast cancer
Stephanie Blockhuys, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 18 (4), p. Article no 871-
Journal article
2017
Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease
M. Pokrzywa, W. E. Kucia, K. Pawelek et al
PLoS ONE. Vol. 12 (9), p. Aet no e0184117-
Journal article
2017
Copper chaperone Atox1 plays role in breast cancer cell migration
Stephanie Blockhuys, Pernilla Wittung Stafshede
Biochemical and Biophysical Research Communications. Vol. 483 (1), p. 301-304
Journal article
2017
Cross-Reactivity of Alpha-Synuclein with Other Cellular Components Can Dramatically Modulate Amyloid Formation
Pernilla Wittung Stafshede
Biophysical Journal. Vol. 112 (3), p. 365A-365A
Scientific journal article - non peer reviewed
2017
Defining the human copper proteome and analysis of its expression variation in cancers.
Amir Feizi, C. Hildesjo, Stephanie Blockhuys et al
Metallomics. Vol. 9 (2), p. 112-123
Journal article
2017
Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast
Kumaravel Ponnandai Shanmugavel, Dina Petranovic Nielsen, Pernilla Wittung Stafshede
Metallomics. Vol. 9 (7), p. 981-988
Journal article
2017
A stretched conformation of DNA with a biological role?
Sandra Rocha, M. Takahashi, Anna Reymer et al
Quarterly Reviews of Biophysics. Vol. 50, p. UNSP e11-
Journal article
2017
Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos
Emanuele Celauro, Amisa Mukaj, Juan Carlos Fierro González et al
Biochemical and Biophysical Research Communications. Vol. 491 (1), p. 147-153
Journal article
2017
Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles
Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Quarterly Reviews of Biophysics. Vol. 50, p. 1-9
Journal article
2016
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.
Marie-Francoise Chesselet, Collin Challis, Timothy R Sampson et al
Cell. Vol. 167 (6), p. 1469-1480.e12
Journal article
2016
Extended functional repertoire for human copper chaperones
Candan Ariöz, Pernilla Wittung Stafshede, Maria Matson Dzebo
Biomolecular Concepts. Vol. 7 (1), p. 29-39
Journal article
2016
Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA
A. Elisabeth Sauer-Eriksson, Christin Grundström, Christopher Andersson et al
Cell Chemical Biology. Vol. 23 (3), p. 404-414
Journal article
2016
A Copper Story: From Protein Folding and Metal Transport to Cancer
Pernilla Wittung Stafshede
Israel Journal of Chemistry. Vol. 56 (9-10), p. 671-681
Journal article
2016
Akademin is Sverige är ej så jämställd som du tror.
Pernilla Wittung Stafshede
Journal article - popular science
2016
Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.
Candan Ariöz, Yaozong Li, Sandra Rocha et al
Biometals (1), p. 27-35
Journal article
2016
Unravelling amyloid formation paths triggered by anionic vesicles of Parkinson’s disease protein, α-synuclein
Pernilla Wittung Stafshede, Sandra Rocha, Istvan Horvath et al
Quarterly Reviews of Biophysics
Journal article
2016
Protein Interactions that Enable Safe and Efficient Copper Ion Transport in the Human Cytoplasm
Pernilla Wittung Stafshede
Biophysical Journal. Vol. 110 (3), p. 179A-179A
Journal article
2016
Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease
Pernilla Wittung Stafshede, Istvan Horvath
Proceedings of the National Academy of Sciences of the United States of America. Vol. 113 (44), p. 12473-12477
Journal article
2016
The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1
Pernilla Wittung Stafshede, M. Kovermann, D. Kahra
Biophysical Journal. Vol. 110 (1), p. 95-102
Journal article
2016
Is the gender gap solved in liberal Sweden?
Pernilla Wittung Stafshede
Journal article - popular science
2016
Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B
T. Mondol, Pernilla Wittung Stafshede, J. Åden
Biochemical and Biophysical Research Communications. Vol. 470 (3), p. 663-669
Journal article
2015
Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.
Sandeep K Sharma, Pernilla Wittung Stafshede, Emma Vernersson-Lindahl et al
Scientific Reports. Vol. 5, p. 12531-
Journal article
2015
The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.
Steve J Matthews, Margery L Evans, Matthew R Chapman et al
Molecular Cell. Vol. 57 (3), p. 445-55
Journal article
2015
Enthalpy-entropy compensation at play in human copper ion transfer.
Moritz S Niemiec, Pernilla Wittung Stafshede, Artur P G Dingeldein
Scientific Reports. Vol. 5, p. 10518-
Journal article
2015
Unresolved questions in human copper pump mechanisms.
Pernilla Wittung Stafshede
Quarterly Reviews of Biophysics. Vol. 48 (4), p. 471-8
Journal article
2015
Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.
Svenja Petzoldt, Dana Kahra, Artur P G Dingeldein et al
Biometals. Vol. 28 (3), p. 577-85
Journal article
2015
Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.
Tanumoy Mondol, Dana Kahra, Moritz S Niemiec et al
Protein and peptide letters. Vol. 22 (6), p. 532-8
Journal article
2015
Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation
T. Kindahl, P. Singh, J. Åden et al
Organic Letters. Vol. 17 (24), p. 6194-6197
Journal article
2015
Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.
Anna Götheson, J. Åden, Neha Jain et al
PLoS ONE. Vol. 10 (10), p. e0140194-
Journal article
2015
Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?
Helena Öhrvik, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 16 (8), p. 16728-39
Journal article
2015
Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice
H. Antti, M. Chermenina, E. Chorell et al
Parkinsons Disease. Vol. 1
Journal article
2015
Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.
Pernilla Wittung Stafshede, Sandeep K Sharma, E. Chorell
Biochemical and Biophysical Research Communications. Vol. 466 (2), p. 192-5
Journal article
2015
Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.
Bente Vestergaard, Christoph Weise, Magnus Wolf-Watz et al
Scientific Reports. Vol. 5, p. 10422-
Journal article
2011
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.
Gunnar Wingsle, Pernilla Wittung Stafshede, Maria E Palm et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 108 (17), p. 6951-6
Journal article
1999
The L2 Loop Peptide of recA Stiffens and restricts Base Motions of Single-stranded DNA Similar to Intact Protein
T. Selmane, Bengt Nordén, M. Takahashi et al
FEBS Letters. Vol. 446 (1), p. 30-34
Journal article
1999
Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties
P.E. Nielsen, G. Haaima, G. Schmidt et al
New Journal of Chemistry. Vol. 23 (8), p. 833-840
Journal article
1999
Peptide nucleic acids
Bengt Nordén, Pernilla Wittung Stafshede
The Encyclopedia of Molecular Biology (ed. Thomas E.Creighton), p. 1801-1808
Chapter in monograph, book
1998
Base Orientation of Second DNA in RecA-DNA Filaments. Analysis by combination of linear dichroism and small angle neutron scattering in flow-oriented solution
Pernilla Wittung Stafshede, K. Mortensen, Hye-Kyung Kim et al
Journal of Biological Chemistry. Vol. 273 (25), p. 15682-15686
Journal article
1997
Observation of a PNA-PNA-PNA triplex
P. Nielsen, Bengt Nordén, Pernilla Wittung Stafshede
Journal of the American Chemical Society. Vol. 119 (13), p. 3189-3190
Journal article
1997
Thermochemical and kinetic evidence for nucleotide-sequence-dependent RecA-DNA interactions
Bengt Nordén, Pernilla Wittung Stafshede, C. Ellouze et al
European Journal of Biochemistry. Vol. 245 (3), p. 715-719
Journal article
1997
Recognition of Double-Stranded DNA by Peptide Nucleic Acids
P. Nielsen, Pernilla Wittung Stafshede, Bengt Nordén
Nucleosides and Nucleotides. Vol. 16 (5-6), p. 599-602
Journal article
1997
Extended DNA-Recognition Repertoire of Peptide Nucleic Acid (PNA): PNA-dsDNA triplex formed with cytosine-rich homopyrimidine PNA
Pernilla Wittung Stafshede, Bengt Nordén, P. Nielsen
Biochemistry. Vol. 36 (26), p. 7973-7979
Journal article
1997
Peptide nucleic acids with a conformationally constrained chiral cyclohexyl-derived backbone
M. Eriksson, P. Nielsen, Bengt Nordén et al
Chemistry - A European Journal. Vol. 3 (6), p. 912-919
Journal article
1996
Ionic effects on the stability and conformation of peptide nucleic acid complexes
P. E. Nielsen, M. Sarkar, Pernilla Wittung Stafshede et al
Journal of the American Chemical Society. Vol. 118 (24), p. 5544-5552
Journal article
1996
Second-site RecA - DNA interactions: Lack of identical recognition
C. Radding, Pernilla Wittung Stafshede, Bengt Nordén et al
Biochemistry. Vol. 35 (48), p. 15349-15355
Journal article
1996
Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA
Pernilla Wittung Stafshede
Doctoral thesis
1996
Direct observation of strand invasion by peptide nucleic acid (PNA) into double-stranded DNA
Bengt Nordén, Pernilla Wittung Stafshede, P. Nielsen
Journal of the American Chemical Society. Vol. 118 (30), p. 7049-7054
Journal article
1995
Fluorescence-detected interactions of oligonucleotides in RecA complexes
Bengt Nordén, Pernilla Wittung Stafshede, M. Takahashi et al
FEBS Letters. Vol. 368 (1), p. 64-68
Journal article
1995
Secondary Structure of RecA in Solution - The Effects of Cofactor, DNA and Ionic Conditions
Pernilla Wittung Stafshede, Bengt Nordén, M. Takahashi
European Journal of Biochemistry. Vol. 228 (1), p. 149-154
Journal article
1995
Functional interactions of nucleic acids : in simple DNA analogs and recombinase intermediates
Pernilla Wittung Stafshede
Licentiate thesis
1995
Induced Chirality in PNA-PNA Duplexes
Bengt Nordén, P. E. Nielsen, Reidar Lyng et al
Journal of the American Chemical Society. Vol. 117 (41), p. 10167-10173
Journal article
1995
Evidence for Elongation of the Helical Pitch of the RecA Filament Upon ATP and ADP Binding Using Small-Angle Neutron Scattering
M. Takahashi, Bengt Nordén, M. Schnarr et al
European Journal of Biochemistry. Vol. 233 (2), p. 579-583
Journal article
1995
PNA-Peptide Chimerae
Pernilla Wittung Stafshede, Bengt Nordén, M. Jorgensen et al
Tetrahedron Letters. Vol. 36 (38), p. 6933-6936
Journal article
1995
Phospholipid membrane permeability of peptide nucleic acid
Bengt Nordén, K. Edwards, Pernilla Wittung Stafshede et al
FEBS Letters. Vol. 365 (1), p. 27-29
Journal article
1994
INTERACTIONS BETWEEN DNA-MOLECULES BOUND TO RECA FILAMENT - EFFECTS OF BASE COMPLEMENTARITY
Bengt Nordén, M. Takahashi, Pernilla Wittung Stafshede et al
Journal of Biological Chemistry. Vol. 269 (8), p. 5799-5803
Journal article
1994
INTERACTIONS OF DNA-BINDING LIGANDS WITH PNA DNA HYBRIDS
O. Buchardt, S. K. Kim, Pernilla Wittung Stafshede et al
Nucleic Acids Research. Vol. 22 (24), p. 5371-5377
Journal article
1994
DNA-LIKE DOUBLE HELIX FORMED BY PEPTIDE NUCLEIC-ACID
Pernilla Wittung Stafshede, M. Egholm, O. Buchardt et al
Nature. Vol. 368 (6471), p. 561-563
Journal article
1994
STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA
M. Egholm, O. Buchardt, P. E. Nielsen et al
Journal of the American Chemical Society. Vol. 116 (18), p. 7964-7970
Journal article
1994
SPECTROSCOPIC OBSERVATION OF RENATURATION BETWEEN POLYNUCLEOTIDES INTERACTING WITH RECA IN THE PRESENCE OF ATP HYDROLYSIS
Bengt Nordén, M. Takahashi, Pernilla Wittung Stafshede
European Journal of Biochemistry. Vol. 224 (1), p. 39-45
Journal article