Pernilla Wittung Stafshede
Pernilla Wittung-Stafshede is since 2015 professor (division head 2015-2018) at the Chemical Biology division in the Life Sciences department. She leads a research group that focuses on metalloprotein mechanisms (e.g., in cancer) and protein misfolding (e.g. in Parkinson's disease). Pernilla has spent 12 years as a professor in the United States (at Tulane and Rice universities) followed by 7 years at Umeå University before she joined Chalmers faculty. She has published over 260 peer-reviewed papers (2022) and many popular texts. Since january 2019, Pernilla is the Head of Genie, Gender Initiative for Excellence, which is a huge 10-year initiative financed by the Foundation in order to improve gender equality among Chalmers faculty.
Showing 125 publications
Biological Amyloids Chemically Damage DNA
Copper ion incorporation in α-synuclein amyloids
Distinct growth regimes of α-synuclein amyloid elongation
Chemical catalysis by biological amyloids
Amyloid Fibers of α-Synuclein Catalyze Chemical Reactions
Amyloids of α-Synuclein Promote Chemical Transformations of Neuronal Cell Metabolites
Memo1 reduces copper-mediated reactive oxygen species in breast cancer cells
Frustration Dynamics and Electron-Transfer Reorganization Energies in Wild-Type and Mutant Azurins
Crossroads between copper ions and amyloid formation in Parkinson's disease
The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation
C-terminal truncation of α-synuclein alters DNA structure from extension to compaction
Macromolecular crowding modulates α-synuclein amyloid fiber growth
Atp7a-regulated enzyme metalation and trafficking in the menkes disease puzzle
Response to crowded conditions reveals compact nucleus for amyloid formation of folded protein
Another pearl in the “copper-transport” necklace
Impact of crowded environments on binding between protein and single-stranded DNA
The Zero-Order Loop in Apoazurin Modulates Folding Mechanism In Silico
Ska vi verkligen ge Astra Zenecas vaccin till äldre?
Effects of the toxic metals arsenite and cadmium on α-synuclein aggregation in vitro and in cells
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
My journey in academia: Things not on the CV
Role of Zero-Order Loop in Protein Unfolding Case Study with Apoazurin
Mirror-Image 5S Ribonucleoprotein Complexes
Female Faculty: Why So Few and Why Care?
Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro
Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer
Alpha-Synuclein Binds to DNA and Modulates its Physical Properties
Wilson disease missense mutations in ATP7B affect metal-binding domain structural dynamics
Copper relay path through the N-terminus of Wilson disease protein, ATP7B
Geometrical Description of Protein Structural Motifs
Folding of copper proteins: Role of the metal?
Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells
Copper Chaperone Atox1 Interacts with Cell Cycle Proteins
Alpha-Synuclein Modulates the Physical Properties of DNA
Abundant fish protein inhibits α-synuclein amyloid formation
In vitro analysis of α-synuclein amyloid formation and cross-reactivity
Synergistic effects of copper sites on apparent stability of multicopper oxidase, Fet3p
3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets
A Luminal Loop of Wilson Disease Protein Binds Copper and Is Required for Protein Activity
Copper chaperone blocks amyloid formation via ternary complex
Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos
Roles of copper-binding proteins in breast cancer
Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast
Defining the human copper proteome and analysis of its expression variation in cancers.
A stretched conformation of DNA with a biological role?
Copper chaperone Atox1 plays role in breast cancer cell migration
Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease
Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA
Protein Interactions that Enable Safe and Efficient Copper Ion Transport in the Human Cytoplasm
The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1
A Copper Story: From Protein Folding and Metal Transport to Cancer
Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B
Akademin is Sverige är ej så jämställd som du tror.
Is the gender gap solved in liberal Sweden?
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.
Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease
Extended functional repertoire for human copper chaperones
The bacterial curli system possesses a potent and selective inhibitor of amyloid formation
Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.
Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.
Unresolved questions in human copper pump mechanisms.
Enthalpy-entropy compensation at play in human copper ion transfer.
Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.
Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.
Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.
Detection of point mutations in DNA by PNA-based quartz-crystal biosensor
In vitro membrane penetration of modified peptide nucleic acid (PNA)
Peptide nucleic acids with a conformationally constrained chiral cyclohexyl-derived backbone
Thermochemical and kinetic evidence for nucleotide-sequence-dependent RecA-DNA interactions
Observation of a PNA-PNA-PNA triplex
Recognition of Double-Stranded DNA by Peptide Nucleic Acids
Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA
Ionic effects on the stability and conformation of peptide nucleic acid complexes
Direct observation of strand invasion by peptide nucleic acid (PNA) into double-stranded DNA
Second-site RecA - DNA interactions: Lack of identical recognition
Phospholipid membrane permeability of peptide nucleic acid
Fluorescence-detected interactions of oligonucleotides in RecA complexes
Induced Chirality in PNA-PNA Duplexes
Functional interactions of nucleic acids : in simple DNA analogs and recombinase intermediates
Secondary Structure of RecA in Solution - The Effects of Cofactor, DNA and Ionic Conditions
DNA-LIKE DOUBLE HELIX FORMED BY PEPTIDE NUCLEIC-ACID
INTERACTIONS OF DNA-BINDING LIGANDS WITH PNA DNA HYBRIDS
STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA
INTERACTIONS BETWEEN DNA-MOLECULES BOUND TO RECA FILAMENT - EFFECTS OF BASE COMPLEMENTARITY
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Showing 15 research projects
Catalytic activity of alpha-synuclein amyloid fibers
Role of Copper Binding to oncogenic Memo1 in Breast Cancer Cells
Role of copper chaperone Atox1 in breast cancer metastasis
Membrane Protein Structure Determination using Atom Probe Tomography
Help a Scientist - subproject 2020 Starhunt
Disease mechanisms of copper chaperone Atox1
Gender Initiative for Excellence (Genie)
Kopparjoners roll vid spridning av cancer
Combining nonlinear spectroscopy and stem cells to understand our "fat problem"
Spegelvänd bioteknik med spegelvända enzymer
Molekylära samspel mellan metalljoner och proteiner vid Parkinsons sjukdom
Mekanismer för kopparjontransport i mänskliga celler
Early structural transformations that promote Parkinson's disease
Female Investigators in Nonlinear Optical Nanoscopy - FINON (FINON)