Gut power: Modulation of human amyloid formation by amyloidogenic proteins in the gastrointestinal tract
Review article, 2022

Protein assembly into amyloid fibers underlies many neurodegenerative disorders. In Parkinson's disease, amyloid formation of α-synuclein is linked to brain cell death. The gut–brain axis plays a key role in Parkinson's disease, and initial α-synuclein amyloid formation may occur distant from the brain. Because different amyloidogenic proteins can cross-seed, and α-synuclein is expressed outside the brain, amyloids present in the gut (from food products and secreted by microbiota) may modulate α-synuclein amyloid formation via direct interactions. I here describe existing such data that only began to appear in the literature in the last few years. The striking, but limited, data set—spanning from acceleration to inhibition—calls for additional investigations that may unravel disease mechanisms as well as new treatments.

Alpha-synuclein

Cross-reactivity

Microbiome

Parkinson's disease

Functional amyloids

Author

Pernilla Wittung Stafshede

Chalmers, Biology and Biological Engineering, Chemical Biology

Current Opinion in Structural Biology

0959-440X (ISSN)

Vol. 72 33-38

Subject Categories

Neurosciences

Cell and Molecular Biology

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

DOI

10.1016/j.sbi.2021.07.009

More information

Latest update

9/23/2021