Pernilla Wittung Stafshede
Professor vid
Chalmers, Biologi och bioteknik, Kemisk biologi
Pernilla Wittung-Stafshede är sedan 2015 professor (och avdelningschef 2015-2018) vid divisionen Kemisk Biologi vid institutionen Biologi och Bioteknik. Hon leder en forskargrupp som fokuserar på metallproteiner (t ex vid cancer) och felveckning (t ex vid Parksinon sjukdom). Pernilla har tidigare arbetat som professor i USA i 12 år vid universiteten Tulane (New Orleans) och Rice (Houston), samt, de följande 7 åren, vid Umeå Universitet innan hon kom till Chalmers. Pernilla Wittung-Stafshede har publicerat mer än 220 forskningsartiklar (2019) och många populärvetenskapliga texter. Sedan januari 2019 leder Pernilla Genie, Gender Initiative for Excellence, vilket är en 10-årig Stiftelse satsning som ska förbättra jämställdheten bland Chalmers lärare och forskare.Wittung-Stafshede ForskningsgruppGenieGenie (Insidan)
Källa: chalmers.se
Visar 76 publikationer
2018
Copper Chaperone Atox1 Interacts with Cell Cycle Proteins
Maria Matson Dzebo, Stephanie Blockhuys, Sebastian Valenzuela et al
Computational and Structural Biotechnology Journal. Vol. 16, p. 443-449
Artikel i vetenskaplig tidskrift
2018
Folding of copper proteins: Role of the metal?
Candan Ariöz, Pernilla Wittung Stafshede
Quarterly Reviews of Biophysics. Vol. 51
Reviewartikel
2018
Abundant fish protein inhibits α-synuclein amyloid formation
Tony Werner, Ranjeet Kumar, Istvan Horvath et al
Scientific Reports. Vol. 8 (1)
Artikel i vetenskaplig tidskrift
2018
Copper chaperone blocks amyloid formation via ternary complex
Istvan Horvath, Tony Werner, Ranjeet Kumar et al
Quarterly Reviews of Biophysics. Vol. 51
Reviewartikel
2018
Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells
Amberlyn M. Wands, Jakob Cervin, He Huang et al
ACS Infectious Diseases. Vol. 4 (5), p. 758-770
Artikel i vetenskaplig tidskrift
2018
The processes of α-synuclein amyloid protein complexes involved in the pathogenesis of Parkinson’s disease
Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. Vol. 118 (8), p. 75-81
Artikel i vetenskaplig tidskrift
2018
Alpha-Synuclein Modulates the Physical Properties of DNA
Kai Jiang, Sandra Rocha, Alvina Westling et al
Chemistry - A European Journal. Vol. 24 (58), p. 15685-15690
Artikel i vetenskaplig tidskrift
2018
Geometrical Description of Protein Structural Motifs
John J. Kozak, Harry B. Gray, Pernilla Wittung Stafshede
Journal of Physical Chemistry B. Vol. 122 (49), p. 11289-11294
Artikel i vetenskaplig tidskrift
2018
In vitro analysis of α-synuclein amyloid formation and cross-reactivity
Istvan Horvath, Sandra Rocha, Pernilla Wittung Stafshede
Methods in Molecular Biology, p. 73-83
Kapitel i bok
2018
Synergistic effects of copper sites on apparent stability of multicopper oxidase, Fet3p
Erik Sedlák, Gabriel Žoldák, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 19 (1)
Artikel i vetenskaplig tidskrift
2018
3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets
Diana Ribeiro, Alexander J. Kvist, Pernilla Wittung Stafshede et al
Stem Cell Reviews and Reports. Vol. 14 (2), p. 177-188
Artikel i vetenskaplig tidskrift
2018
A Luminal Loop of Wilson Disease Protein Binds Copper and Is Required for Protein Activity
Birgit Köhn, Kumaravel Ponnandai Schanmugavel, Min Wu et al
Biophysical Journal. Vol. 115 (6), p. 1007-1018
Artikel i vetenskaplig tidskrift
2018
Copper distribution in breast cancer cells detected by time-of-flight secondary ion mass spectrometry with delayed extraction methodology
Stephanie Blockhuys, Per Malmberg, Pernilla Wittung Stafshede
Biointerphases. Vol. 13 (6)
Artikel i vetenskaplig tidskrift
2017
The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations
Candan Ariöz, Y. Z. Li, Pernilla Wittung Stafshede
Biometals. Vol. 30 (6), p. 823-840
Artikel i vetenskaplig tidskrift
2017
Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease
M. Pokrzywa, K. Pawelek, W. E. Kucia et al
PLoS ONE. Vol. 12 (9), p. Aet no e0184117-
Artikel i vetenskaplig tidskrift
2017
Copper chaperone Atox1 plays role in breast cancer cell migration
Stephanie Blockhuys, Pernilla Wittung Stafshede
Biochemical and Biophysical Research Communications. Vol. 483 (1), p. 301-304
Artikel i vetenskaplig tidskrift
2017
Roles of copper-binding proteins in breast cancer
Stephanie Blockhuys, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 18 (4), p. Article no 871-
Artikel i vetenskaplig tidskrift
2017
Defining the human copper proteome and analysis of its expression variation in cancers.
Stephanie Blockhuys, Emanuele Celauro, C. Hildesjo et al
Metallomics. Vol. 9 (2), p. 112-123
Artikel i vetenskaplig tidskrift
2017
Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation
Diana Ribeiro, Istvan Horvath, N. Heath et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 114 (42), p. 11127-11132
Artikel i vetenskaplig tidskrift
2017
Cross-Reactivity of Alpha-Synuclein with Other Cellular Components Can Dramatically Modulate Amyloid Formation
Pernilla Wittung Stafshede
Biophysical Journal. Vol. 112 (3), p. 365A-365A
Artikel i övriga tidskrifter
2017
Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast
Kumaravel Ponnandai Shanmugavel, Dina Petranovic Nielsen, Pernilla Wittung Stafshede
Metallomics. Vol. 9 (7), p. 981-988
Artikel i vetenskaplig tidskrift
2017
Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast
Kumaravel Ponnandai Shanmugavel, Dina Petranovic Nielsen, Pernilla Wittung Stafshede
Metallomics. Vol. 9 (7), p. 981-988
Artikel i vetenskaplig tidskrift
2017
A stretched conformation of DNA with a biological role?
Niklas Bosaeus, Anna Reymer, Tamas Beke-Somfai et al
Quarterly Reviews of Biophysics. Vol. 50, p. UNSP e11-
Artikel i vetenskaplig tidskrift
2017
Second harmonic generation for collagen I characterization in rectal cancer patients with and without preoperative radiotherapy
Stephanie Blockhuys, Nisha Rani Agarwal, C. Hildesjo et al
Journal of Biomedical Optics. Vol. 22 (10)
Artikel i vetenskaplig tidskrift
2017
Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos
Emanuele Celauro, Amisa Mukaj, Juan Carlos Fierro González et al
Biochemical and Biophysical Research Communications. Vol. 491 (1), p. 147-153
Artikel i vetenskaplig tidskrift
2017
Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles
Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Quarterly Reviews of Biophysics. Vol. 50, p. 1-9
Artikel i vetenskaplig tidskrift
2016
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.
Timothy R Sampson, Justine W Debelius, Taren Thron et al
Cell. Vol. 167 (6), p. 1469-1480.e12
Artikel i vetenskaplig tidskrift
2016
Extended functional repertoire for human copper chaperones
Maria Matson Dzebo, Candan Ariöz, Pernilla Wittung Stafshede
Biomolecular Concepts. Vol. 7 (1), p. 29-39
Artikel i vetenskaplig tidskrift
2016
A Copper Story: From Protein Folding and Metal Transport to Cancer
Pernilla Wittung Stafshede
Israel Journal of Chemistry. Vol. 56 (9-10), p. 671-681
Artikel i vetenskaplig tidskrift
2016
Akademin is Sverige är ej så jämställd som du tror.
Pernilla Wittung Stafshede
Curie Vetenskapsrådets webb tidning
Artikel i övriga tidskrifter
2016
Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA
James A D Good, Christopher Andersson, Sabine Hansen et al
Cell Chemical Biology. Vol. 23 (3), p. 404-414
Artikel i vetenskaplig tidskrift
2016
Protein Interactions that Enable Safe and Efficient Copper Ion Transport in the Human Cytoplasm
Pernilla Wittung Stafshede
Biophysical Journal. Vol. 110 (3), p. 179A-179A
Artikel i vetenskaplig tidskrift
2016
Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease
Istvan Horvath, Pernilla Wittung Stafshede
Proceedings of the National Academy of Sciences of the United States of America. Vol. 113 (44), p. 12473-12477
Artikel i vetenskaplig tidskrift
2016
Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.
Ranjeet Kumar, Candan Ariöz, Yaozong Li et al
Biometals (1), p. 27-35
Artikel i vetenskaplig tidskrift
2016
The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1
D. Kahra, M. Kovermann, Pernilla Wittung Stafshede
Biophysical Journal. Vol. 110 (1), p. 95-102
Artikel i vetenskaplig tidskrift
2016
Is the gender gap solved in liberal Sweden?
Pernilla Wittung Stafshede
stemwomen.net
Artikel i övriga tidskrifter
2016
gästbloggare
Pernilla Wittung Stafshede
Curie Vetenskapsrådets webb tidning
Artikel i övriga tidskrifter
2016
Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B
T. Mondol, J. Åden, Pernilla Wittung Stafshede
Biochemical and Biophysical Research Communications. Vol. 470 (3), p. 663-669
Artikel i vetenskaplig tidskrift
2015
Enthalpy-entropy compensation at play in human copper ion transfer.
Moritz S Niemiec, Artur P G Dingeldein, Pernilla Wittung Stafshede
Scientific Reports. Vol. 5, p. 10518-
Artikel i vetenskaplig tidskrift
2015
The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.
Margery L Evans, E. Chorell, Jonathan D Taylor et al
Molecular Cell. Vol. 57 (3), p. 445-55
Artikel i vetenskaplig tidskrift
2015
Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.
Sandeep K Sharma, E. Chorell, Pär Steneberg et al
Scientific Reports. Vol. 5, p. 12531-
Artikel i vetenskaplig tidskrift
2015
Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.
Dana Kahra, Tanumoy Mondol, Moritz S Niemiec et al
Protein and peptide letters. Vol. 22 (6), p. 532-8
Artikel i vetenskaplig tidskrift
2015
Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.
Svenja Petzoldt, Dana Kahra, Michael Kovermann et al
Biometals. Vol. 28 (3), p. 577-85
Artikel i vetenskaplig tidskrift
2015
Unresolved questions in human copper pump mechanisms.
Pernilla Wittung Stafshede
Quarterly Reviews of Biophysics. Vol. 48 (4), p. 471-8
Artikel i vetenskaplig tidskrift
2015
Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.
E. Chorell, Emma Andersson, Margery L Evans et al
PLoS ONE. Vol. 10 (10), p. e0140194-
Artikel i vetenskaplig tidskrift
2015
Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation
P. Singh, E. Chorell, K.S. Krishnan et al
Organic Letters. Vol. 17 (24), p. 6194-6197
Artikel i vetenskaplig tidskrift
2015
Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?
Helena Öhrvik, Pernilla Wittung Stafshede
International Journal of Molecular Sciences. Vol. 16 (8), p. 16728-39
Artikel i vetenskaplig tidskrift
2015
Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.
Martin Nors Perdersen, Vito Foderà, Istvan Horvath et al
Scientific Reports. Vol. 5, p. 10422-
Artikel i vetenskaplig tidskrift
2015
Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.
Sandeep K Sharma, E. Chorell, Pernilla Wittung Stafshede
Biochemical and Biophysical Research Communications. Vol. 466 (2), p. 192-5
Artikel i vetenskaplig tidskrift
2015
Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice
M. Chermenina, E. Chorell, M. Pokrzywa et al
Parkinsons Disease. Vol. 1
Artikel i vetenskaplig tidskrift
2011
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.
Maria E Palm, Christoph F Weise, Christina Lundin et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 108 (17), p. 6951-6
Artikel i vetenskaplig tidskrift
1999
The L2 Loop Peptide of recA Stiffens and restricts Base Motions of Single-stranded DNA Similar to Intact Protein
T. Selmane, Pernilla Wittung Stafshede, F. Maraboeuf et al
FEBS Letters. Vol. 446 (1), p. 30-34
Artikel i vetenskaplig tidskrift
1999
Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties
G. Haaima, H. Rasmussen, G. Schmidt et al
New Journal of Chemistry. Vol. 23 (8), p. 833-840
Artikel i vetenskaplig tidskrift
1999
Peptide nucleic acids
Bengt Nordén, Pernilla Wittung Stafshede
The Encyclopedia of Molecular Biology (ed. Thomas E.Creighton), p. 1801-1808
Kapitel i bok
1998
Base Orientation of Second DNA in RecA-DNA Filaments. Analysis by combination of linear dichroism and small angle neutron scattering in flow-oriented solution
Bengt Nordén, Pernilla Wittung Stafshede, C. Ellouze et al
Journal of Biological Chemistry. Vol. 273 (25), p. 15682-15686
Artikel i vetenskaplig tidskrift
1997
Recognition of Double-Stranded DNA by Peptide Nucleic Acids
Pernilla Wittung, P. Nielsen, Bengt Nordén
Nucleosides and Nucleotides. Vol. 16 (5-6), p. 599-602
Artikel i vetenskaplig tidskrift
1997
Observation of a PNA-PNA-PNA triplex
Pernilla Wittung, P. Nielsen, Bengt Nordén
Journal of the American Chemical Society. Vol. 119 (13), p. 3189-3190
Artikel i vetenskaplig tidskrift
1997
Thermochemical and kinetic evidence for nucleotide-sequence-dependent RecA-DNA interactions
Pernilla Wittung, C. Ellouze, F. Maraboeuf et al
European Journal of Biochemistry. Vol. 245 (3), p. 715-719
Artikel i vetenskaplig tidskrift
1997
Extended DNA-Recognition Repertoire of Peptide Nucleic Acid (PNA): PNA-dsDNA triplex formed with cytosine-rich homopyrimidine PNA
Pernilla Wittung, P. Nielsen, Bengt Nordén
Biochemistry. Vol. 36 (26), p. 7973-7979
Artikel i vetenskaplig tidskrift
1997
Peptide nucleic acids with a conformationally constrained chiral cyclohexyl-derived backbone
P. Lagriffoule, Pernilla Wittung, M. Eriksson et al
Chemistry - A European Journal. Vol. 3 (6), p. 912-919
Artikel i vetenskaplig tidskrift
1996
Ionic effects on the stability and conformation of peptide nucleic acid complexes
S. Tomac, M. Sarkar, Tommi Ratilainen et al
Journal of the American Chemical Society. Vol. 118 (24), p. 5544-5552
Artikel i vetenskaplig tidskrift
1996
Second-site RecA - DNA interactions: Lack of identical recognition
Pernilla Wittung, L. R. Bazemore, M. Takahashi et al
Biochemistry. Vol. 35 (48), p. 15349-15355
Artikel i vetenskaplig tidskrift
1996
Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA
Pernilla Wittung
Doktorsavhandling
1996
Direct observation of strand invasion by peptide nucleic acid (PNA) into double-stranded DNA
Pernilla Wittung, P. Nielsen, Bengt Nordén
Journal of the American Chemical Society. Vol. 118 (30), p. 7049-7054
Artikel i vetenskaplig tidskrift
1995
Functional interactions of nucleic acids : in simple DNA analogs and recombinase intermediates
Pernilla Wittung
Licentiatavhandling
1995
Secondary Structure of RecA in Solution - The Effects of Cofactor, DNA and Ionic Conditions
Pernilla Wittung, Bengt Nordén, M. Takahashi
European Journal of Biochemistry. Vol. 228 (1), p. 149-154
Artikel i vetenskaplig tidskrift
1995
Fluorescence-detected interactions of oligonucleotides in RecA complexes
Pernilla Wittung, M. Funk, B. Jernstrom et al
FEBS Letters. Vol. 368 (1), p. 64-68
Artikel i vetenskaplig tidskrift
1995
Induced Chirality in PNA-PNA Duplexes
Pernilla Wittung, M. Eriksson, Reidar Lyng et al
Journal of the American Chemical Society. Vol. 117 (41), p. 10167-10173
Artikel i vetenskaplig tidskrift
1995
Evidence for Elongation of the Helical Pitch of the RecA Filament Upon ATP and ADP Binding Using Small-Angle Neutron Scattering
C. Ellouze, M. Takahashi, Pernilla Wittung et al
European Journal of Biochemistry. Vol. 233 (2), p. 579-583
Artikel i vetenskaplig tidskrift
1995
PNA-Peptide Chimerae
T. Koch, M. Naesby, Pernilla Wittung et al
Tetrahedron Letters. Vol. 36 (38), p. 6933-6936
Artikel i vetenskaplig tidskrift
1995
Phospholipid membrane permeability of peptide nucleic acid
Pernilla Wittung, Johan Kajanus, K. Edwards et al
FEBS Letters. Vol. 365 (1), p. 27-29
Artikel i vetenskaplig tidskrift
1994
INTERACTIONS OF DNA-BINDING LIGANDS WITH PNA DNA HYBRIDS
Pernilla Wittung, S. K. Kim, O. Buchardt et al
Nucleic Acids Research. Vol. 22 (24), p. 5371-5377
Artikel i vetenskaplig tidskrift
1994
INTERACTIONS BETWEEN DNA-MOLECULES BOUND TO RECA FILAMENT - EFFECTS OF BASE COMPLEMENTARITY
Pernilla Wittung, Bengt Nordén, S. K. Kim et al
Journal of Biological Chemistry. Vol. 269 (8), p. 5799-5803
Artikel i vetenskaplig tidskrift
1994
DNA-LIKE DOUBLE HELIX FORMED BY PEPTIDE NUCLEIC-ACID
Pernilla Wittung, P. E. Nielsen, O. Buchardt et al
Nature. Vol. 368 (6471), p. 561-563
Artikel i vetenskaplig tidskrift
1994
SPECTROSCOPIC OBSERVATION OF RENATURATION BETWEEN POLYNUCLEOTIDES INTERACTING WITH RECA IN THE PRESENCE OF ATP HYDROLYSIS
Pernilla Wittung, Bengt Nordén, M. Takahashi
European Journal of Biochemistry. Vol. 224 (1), p. 39-45
Artikel i vetenskaplig tidskrift
1994
STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA
B. Hyrup, M. Egholm, P. E. Nielsen et al
Journal of the American Chemical Society. Vol. 116 (18), p. 7964-7970
Artikel i vetenskaplig tidskrift
Visar 7 forskningsprojekt
2018–2020
Kopparjoners roll vid spridning av cancer
Pernilla Wittung Stafshede
Kemisk biologi
Cancerfonden
2017–2018
Combining nonlinear spectroscopy and stem cells to understand our "fat problem"
Pernilla Wittung Stafshede
Kemisk biologi
Stiftelsen Wilhelm och Martina Lundgrens Vetenskapsfond
2017–2018
Molekylära samspel mellan metalljoner och proteiner vid Parkinsons sjukdom
Pernilla Wittung Stafshede
Kemisk biologi
Stiftelsen Olle Engkvist Byggmästare
2017–2018
Spegelvänd bioteknik med spegelvända enzymer
Pernilla Wittung Stafshede
Kemisk biologi
Vetenskapsrådet (VR)
2016–2020
Mekanismer för kopparjontransport i mänskliga celler
Pernilla Wittung Stafshede
Kemisk biologi
Vetenskapsrådet (VR)
2015–2017
Early structural transformations that promote Parkinson's disease
Pernilla Wittung Stafshede
Kemisk biologi
Parkinsonfonden
2013–2017
Female Investigators in Nonlinear Optical Nanoscopy - FINON (FINON)
Pernilla Wittung Stafshede
Kemisk biologi
Michael Stuhrenberg
Molekylär mikroskopi
Alexandra Paul
Molekylär mikroskopi
Europeiska kommissionen (FP7)
Det kan finnas fler projekt där Pernilla Wittung Stafshede medverkar, men du måste vara inloggad som anställd på Chalmers för att kunna se dem.