Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation
Artikel i vetenskaplig tidskrift, 2015

© 2015 American Chemical Society. An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted, intramolecular C-H amination reaction is reported. All the synthesized polyheterocycles were evaluated for their fluorescent properties and effect on α-synuclein amyloid formation.

Författare

P. Singh

Umeå universitet

E. Chorell

Umeå universitet

K.S. Krishnan

Mannam Memorial NSS College

T. Kindahl

Umeå universitet

J. Åden

Umeå universitet

Pernilla Wittung Stafshede

Chalmers, Biologi och bioteknik, Kemisk biologi

F. Almqvist

Umeå universitet

Organic Letters

1523-7060 (ISSN) 1523-7052 (eISSN)

Vol. 17 6194-6197

Ämneskategorier

Kemi

DOI

10.1021/acs.orglett.5b03190