Polycyclizations of Ketoesters: Synthesis of Complex Tricycles with up to Five Stereogenic Centers from Available Starting Materials
Journal article, 2020
Here we present a polycyclization of oxotriphenylhexanoates. The polycyclization is governed by electronic effects, and three major synthetic paths have been established leading to stereochemically complex tricyclic frameworks with up to five stereogenic centers. The method is compatible with an array of functional groups, allowing pharmacophoric elements to be introduced post cyclization.
Author
Martin Kamlar
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Charles University
August Runemark
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Ivana Císařová
Charles University
Henrik Sundén
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
University of Gothenburg
Organic Letters
1523-7060 (ISSN) 1523-7052 (eISSN)
Vol. 22 21 8387-8391Subject Categories
Inorganic Chemistry
Theoretical Chemistry
Organic Chemistry
DOI
10.1021/acs.orglett.0c03020
PubMed
33079554