Polycyclizations of Ketoesters: Synthesis of Complex Tricycles with up to Five Stereogenic Centers from Available Starting Materials
Artikel i vetenskaplig tidskrift, 2020

Here we present a polycyclization of oxotriphenylhexanoates. The polycyclization is governed by electronic effects, and three major synthetic paths have been established leading to stereochemically complex tricyclic frameworks with up to five stereogenic centers. The method is compatible with an array of functional groups, allowing pharmacophoric elements to be introduced post cyclization.

Författare

Martin Kamlar

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Univerzita Karlova

August Runemark

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Ivana Císařová

Univerzita Karlova

Henrik Sundén

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Göteborgs universitet

Organic Letters

1523-7060 (ISSN) 1523-7052 (eISSN)

Vol. 22 21 8387-8391

Ämneskategorier

Oorganisk kemi

Teoretisk kemi

Organisk kemi

DOI

10.1021/acs.orglett.0c03020

PubMed

33079554

Mer information

Senast uppdaterat

2021-01-04