Multimodal chemical imaging of a single brain tissue section using ToF-SIMS, MALDI-ToF and immuno/histochemical staining
Journal article, 2021

Cluster ion beam ToF-SIMS and/or MALDI-ToF mass spectrometry imaging (using 1,5-DAN matrix via sublimation) of a single coronal rat brain tissue section followed by classical-or immuno-histochemical staining faclilated a new multimodal chemical imaging workflow allowing complementary correlation of the lipid molecular ion images with the immuno/histological features within cerebellum region of the same brain tisue section.


Ibrahim Kaya

University of Gothenburg

Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform

Uppsala University

Sahlgrenska University Hospital

Eva Jennische

University of Gothenburg

Stefan Lange

University of Gothenburg

Per Malmberg

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform

The Analyst

0003-2654 (ISSN) 1364-5528 (eISSN)

Vol. 146 4 1169-1177

Subject Categories

Atom and Molecular Physics and Optics

Radiology, Nuclear Medicine and Medical Imaging

Medical Image Processing


Chemical Imaging Infrastructure





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