Multimodal chemical imaging of a single brain tissue section using ToF-SIMS, MALDI-ToF and immuno/histochemical staining
Journal article, 2021
Cluster ion beam ToF-SIMS and/or MALDI-ToF mass spectrometry imaging (using 1,5-DAN matrix via sublimation) of a single coronal rat brain tissue section followed by classical-or immuno-histochemical staining faclilated a new multimodal chemical imaging workflow allowing complementary correlation of the lipid molecular ion images with the immuno/histological features within cerebellum region of the same brain tisue section.
Author
Ibrahim Kaya
University of Gothenburg
Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform
Uppsala University
Sahlgrenska University Hospital
Eva Jennische
University of Gothenburg
Stefan Lange
University of Gothenburg
Per Malmberg
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform
The Analyst
0003-2654 (ISSN) 1364-5528 (eISSN)
Vol. 146 4 1169-1177Subject Categories
Atom and Molecular Physics and Optics
Radiology, Nuclear Medicine and Medical Imaging
Medical Image Processing
Infrastructure
Chemical Imaging Infrastructure
DOI
10.1039/d0an02172e
PubMed
33393562