Per Malmberg
My research is all about analytical chemistry, especially mass spectrometry. I've been developing secondary ion mass spectrometry (SIMS) methods like ToF-SIMS and NanoSIMS, as well as MALDI for mass spectrometry imaging (MSI). MSI creates chemical maps by acquiring mass spectra from individual points in a sample, resulting in spatially resolved images with elemental or molecular information. My research focuses on these main areas: Nano Metals in Biology: I'm passionate about understanding nanometals interaction in biology. In a Swedish Research Council project, I developed methods to trace zinc and other metals in the brain and nervous system. This work has led to several publications and a PhD graduation. We've studied subcellular localization of nano-zinc, iron, and copper using NanoSIMS, achieving sub-25 nm imaging of iron in cells. We've also published data on nanoparticles of iron in COPD and metal allergens in skin tissue. Im also interested in subcelluar uptake of metals and nanoparticles from pollution and the connection to disease. Early Cancer Detection: In collaboration with Lund University, we have developed a method to early determine the presence of cancer based on changes in the isotope balance of a large number of elements. We also study how molecules in the tumor environment are affected by disruptions in the isotope balance. Drug Development and Safety: I'm involved in the IMI/EU-funded TRISTAN project, tracing nano-drugs and nano-metabolites with mass spectrometry to develop new nano-drug safety methods. I've studied how 89Zr-Trastuzumab, a nano-metal-tagged antibody for breast cancer, interacts with tissue and cells. This bridges into nano-metals in biology, focusing on nano-metal-chelates analyzed with PET and MSI techniques. This helps us understand nano-drug interactions, especially in cancer treatment. I'm also collaborating with AstraZeneca to develop techniques for sub-cellular drug localization and quantification. Nano Surfaces and Interfaces: I'm interested in how cells and materials interact on a nano-scale. I've explored nano-graphene interactions, hydrogen/deuterium integration in oxides, and nano-biomaterials like titanium and magnesium. Mapping nano structured implant reactions with blood is crucial for understanding bone healing and soft tissue responses. MSI provides a comprehensive picture by mapping both metals and organic components simultaneously.
Showing 114 publications
ToF-SIMS analyses of brake wear particles in human epithelial Caco-2 cells
Oxidation of a zirconium nitride multilayer-covered knee implant after two years in clinical use
Mitigation of interfacial dielectric loss in aluminum-on-silicon superconducting qubits
Alterations of the chemical profile of cholesterol in cancer tissue as traced with ToF-SIMS
Evidence for intracellular silicon uptake in RAW264.7 cells, possibly mediated by aquaporin 9
Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation
Distinct Cholesterol Localization in Glioblastoma Multiforme Revealed by Mass Spectrometry Imaging
Field Manipulation of Band Properties in Infrared Spectra of Thin Films
Bonding between π-Conjugated Polycations and Monolayer Graphene: Decisive Role of Anions
Skin permeation studies of chromium species – Evaluation of a reconstructed human epidermis model
Correlative High-Resolution Imaging of Iron Uptake in Lung Macrophages
Topical Application of Metal Allergens Induces Changes to Lipid Composition of Human Skin
On the function of lead (Pb) in machining brass alloys
Animal- free skin permeation analysis using mass spectrometry imaging
Mapping the chemistry of hair strands by mass spectrometry imaging - A Review
Multiple growth of graphene from a pre-dissolved carbon source
Evidence for Electron Transfer between Graphene and Non-Covalently Bound pi-Systems
Subcellular Mass Spectrometry Imaging and Absolute Quantitative Analysis across Organelles
ToF-SIMS imaging of dual biomolecular monolayer gradients
Copper nanoparticles have negligible direct antibacterial impact
Molecular insights into hypomineralized enamel
Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis
Mass spectrometry imaging as a novel approach to measure hippocampal zinc
Interplay of water and reactive elements in oxidation of alumina-forming alloys
Soft-tissue evidence for homeothermy and crypsis in a Jurassic ichthyosaur
Graphene Oxide Elicits Membrane Lipid Changes and Neutrophil Extracellular Trap Formation
Nano Secondary Ion Mass Spectrometry Imaging of Dopamine Distribution Across Nanometer Vesicles
Formation of hydroxyapatite on titanium implants in vivo precedes bone-formation during healing
Mg-corrosion, hydroxyapatite, and bone healing
Antisecretory Factor (AF) egg-yolk peptides reflects the intake of AF-activating feed in hens
Mineralization at Titanium Surfaces is a Two-Step Process.
Multimodal Imaging of Chemically Fixed Cells in Preparation for NanoSIMS
Food-induced changes of lipids in rat neuronal tissue visualized by ToF-SIMS imaging
A ToF-SIMS investigation of the corrosion behavior of Mg alloy AM50 in atmospheric environments
XRMA and ToF-SIMS Analysis of Normal and Hypomineralized Enamel.
Spatial neuroproteomics using imaging mass spectrometry
Analysis of liposome model systems by time-of-flight secondary ion mass spectrometry
Increase of Compact Bone Thickness in Rat Tibia after Implanting MgO into the Bone Marrow Cavity
Using imaging ToF-SIMS data to determine the cell wall thickness of fibers in wood
Analysis of As- and Hg-Species in Metal-Resistant Oral Bacteria, by Imaging ToF-SIMS
High-resolution, imaging TOF-SIMS: novel applications in medical research
High-resolution imaging and proteomics of peptide fragments by TOF-SIMS
Molecular imaging of lipids in cells and tissues
Bioimaging TOF-SIMS: High resolution 3D imaging of single cells.
High resolution imaging by organic secondary ion mass spectrometry.
Imaging of lipids in human adipose tissue by cluster ion TOF-SIMS
Localization of lipids in the aortic wall with imaging TOF-SIMS
Localization of cholesterol in rat cerebellum with imaging TOF-SIMS Effect of tissue preparation
Depth profiling of cells and tissues by using C-60(+) and SF5+ as sputter ions
Distribution of cholesterol and galactosylceramide in rat cerebellar white matter.
Localization of Na+ and K+ in rat cerebellum with imaging TOF-SIMS
Imaging TOF-SIMS of rat kidney prepared by high-pressure freezing.
Bioimaging TOF-SIMS of tissues by gold ion bombardment of a silver-coated thin section.
Development of a wound dressing targeting neutrophil function.
Bioimaging TOF-SIMS: localization of cholesterol in rat kidney sections.
Subcellular localisation of cholesterol and phosphocholine with pattern-recognition-imaging-TOF-SIMS
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Showing 8 research projects
Pollution and subcellular effects – the connection to non-communicable diseases
Pollution and subcellular accumulation of metals – the connection to non-communicable diseases
Dermal uptake of polycyclic aromatic compounds by work environment exposure
Kemisk avbildning för hudpermeationsstudier - ett metod för att ersätta djurförsök
Chemical imaging analysis of skin permeation of sensitizing and toxic metals
Chemical imaging for skin permeation studies – an analytical approach to replace animal experiments