Kemisk avbildning för studier av hudupptag
Forskningsprojekt, 2020

In this project we want to develop an animal-free skin permeation analysis approach suitable for testing chemicals such as pharmaceuticals, cosmetics and skin allergens. The method uses multi-modal chemical imaging (MMCI) to trace, quantify and image molecules and elements in donated human skin after a diffusion cell exposure. The method aims to replace or significantly reduce existing in-vivo models and improve on already established in-vitro models. This by offering a more sensitive and flexible analytical approach that can replace and/or complement existing methods in the OECD guidelines for skin adsorption (no 427 and no 428). Although the use of in-vivo testing of cosmetic ingredients with regard to skin sensitizing potency is prohibited since many years, the replacement methods validated by ECVAM does not take skin permeation into account.


Per Malmberg (kontakt)

Chalmers, Kemi och kemiteknik, Kemi och biokemi


Sahlgrenska universitetssjukhuset

Gothenburg, Sweden


Forska utan Djurförsök

Projekt-id: N2019-0001
Finansierar Chalmers deltagande under 2020

Forska utan Djurförsök

Projekt-id: F2020-0001
Finansierar Chalmers deltagande under 2020–2022

Relaterade styrkeområden och infrastruktur

Chalmers infrastruktur för masspektrometri


Hälsa och teknik


Infrastruktur för kemisk avbildning



Mer information

Projektets webbplats

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