Imaging the distribution of DMPBD and terpinen-4-ol inclusion complexes with 2-hydroxypropyl-beta-cyclodextrin by using TOF-SIMS
Journal article, 2021

The distribution of terpinen-4-ol (TP4ol) and DMPBD inclusion complexes with 2-hydroxypropyl-beta-cyclodextrin (HPbCD) in human skin has been investigated using the TOF-SIMS technique. TP4ol and DMPBD have been found to be major components of Zingiber cassumunar Roxb. (Plai) oil extracted by steam distillation. The results mainly show accumulation of TP4ol and DMPBD inclusion complexes with HPbCD in the epidermis and dermis whereas these two compounds without cyclodextrin cannot penetrate into the epidermis. This approach can be expanded for investigation of anti-inflammatory action and relief of muscle pain.

Author

Auraya Manaprasertsak

Kasetsart University

Per Malmberg

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Theerachart Leepasert

Kasetsart University

Thitinun Karpkird

Kasetsart University

Analytical Methods

1759-9660 (ISSN) 1759-9679 (eISSN)

Vol. 13 1 84-89

Subject Categories

Analytical Chemistry

Other Basic Medicine

Pharmacology and Toxicology

DOI

10.1039/d0ay02018d

PubMed

33300895

More information

Latest update

2/8/2021 8