Imaging the distribution of DMPBD and terpinen-4-ol inclusion complexes with 2-hydroxypropyl-beta-cyclodextrin by using TOF-SIMS
Artikel i vetenskaplig tidskrift, 2021
The distribution of terpinen-4-ol (TP4ol) and DMPBD inclusion complexes with 2-hydroxypropyl-beta-cyclodextrin (HPbCD) in human skin has been investigated using the TOF-SIMS technique. TP4ol and DMPBD have been found to be major components of Zingiber cassumunar Roxb. (Plai) oil extracted by steam distillation. The results mainly show accumulation of TP4ol and DMPBD inclusion complexes with HPbCD in the epidermis and dermis whereas these two compounds without cyclodextrin cannot penetrate into the epidermis. This approach can be expanded for investigation of anti-inflammatory action and relief of muscle pain.
Författare
Auraya Manaprasertsak
Kasetsart University
Per Malmberg
Chalmers, Kemi och kemiteknik, Kemi och biokemi
Theerachart Leepasert
Kasetsart University
Thitinun Karpkird
Kasetsart University
Analytical Methods
1759-9660 (ISSN) 1759-9679 (eISSN)
Vol. 13 1 84-89Ämneskategorier
Analytisk kemi
Annan medicinsk grundvetenskap
Farmakologi och toxikologi
Infrastruktur
Infrastruktur för kemisk avbildning
DOI
10.1039/d0ay02018d
PubMed
33300895