MgO implanted in rat tibia bone marrow is osteoinductive through the formation of a matrix, containing hydroxyapatite
Paper in proceedings, 2017

Healing of rat tibia after intramedullary implantation of MgO was analysed by Environmental Scanning Electron Microscopy (ESEM) and Energy-Dispersive X-ray spectroscopy (EDX). The results indicated the formation of hydroxyl-apatite (HA) in the entire intramedullary space after 1 week of healing. Then, corroded Mg, MgO and MgCO3 were incubated with DMEM in vitro for 24 h and the surface of the material was analysed by EDX and Time-of-Flight Secondary Ion Mass (ToF-SIMS). The chemical analysis of the Mg corrosion products indicate that HA is formed at the material surface and that MgCO3 was an efficient catalyzer of HA formation. © 2017 Trans Tech Publications, Switzerland.


Bone cement


Bone healing


Håkan Nygren

University of Gothenburg

Per Malmberg

Loughborough University

Yang Liu

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Analytical Chemistry

Materials Science Forum

0255-5476 (ISSN)

Vol. 879 1404-1407

Subject Categories

Analytical Chemistry





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5/2/2018 2