Gold and silver nanoparticle-assisted laser desorption ionization mass spectrometry compatible with secondary ion mass spectrometry for lipid analysis
Journal article, 2014

To provide a convenient organic matrix-free spray-on sample preparation for laser desorption ionization (LDI) that is compatible with secondary ion mass spectrometry (SIMS) imaging mass spectrometry (IMS) techniques, silver and gold nanoparticles (NPs) were applied on a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid sample. Application of Ag and Au nanoparticles to the POPC sample allowed POPC lipid fragments to be detected using NP-LDI in both positive and negative polarities. In addition, the same sample prepared for NP-LDI experiments was used for C-60 SIMS lipid analysis, and a secondary ion signal enhancement was obtained for the [M+H](+) ion of the POPC lipid as well as for characteristics POPC lipid fragments in positive ion mode.

IMS lipid analysis

NPs spray-on procedure

LDI mass spectrometry compatible with SIMS

Au Ag nanoparticle LDI

Au and Ag nanoparticles


Amir Saeid Mohammadi

Chalmers, Chemical and Biological Engineering, Physical Chemistry

John Fletcher

University of Gothenburg

Per Malmberg

University of Gothenburg

Andrew Ewing

Chalmers, Chemical and Biological Engineering, Analytical Chemistry

University of Gothenburg

Surface and Interface Analysis

0142-2421 (ISSN) 1096-9918 (eISSN)

Vol. 46 S1 379-382

Subject Categories

Physical Chemistry

Analytical Chemistry

Chemical Engineering



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