Gold and silver nanoparticle-assisted laser desorption ionization mass spectrometry compatible with secondary ion mass spectrometry for lipid analysis
Artikel i vetenskaplig tidskrift, 2014

To provide a convenient organic matrix-free spray-on sample preparation for laser desorption ionization (LDI) that is compatible with secondary ion mass spectrometry (SIMS) imaging mass spectrometry (IMS) techniques, silver and gold nanoparticles (NPs) were applied on a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid sample. Application of Ag and Au nanoparticles to the POPC sample allowed POPC lipid fragments to be detected using NP-LDI in both positive and negative polarities. In addition, the same sample prepared for NP-LDI experiments was used for C-60 SIMS lipid analysis, and a secondary ion signal enhancement was obtained for the [M+H](+) ion of the POPC lipid as well as for characteristics POPC lipid fragments in positive ion mode.

IMS lipid analysis

NPs spray-on procedure

LDI mass spectrometry compatible with SIMS

Au Ag nanoparticle LDI

Au and Ag nanoparticles

Författare

Amir Saeid Mohammadi

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

John Fletcher

Göteborgs universitet

Per Malmberg

Göteborgs universitet

Andrew Ewing

Chalmers, Kemi- och bioteknik, Analytisk kemi

Göteborgs universitet

Surface and Interface Analysis

0142-2421 (ISSN) 1096-9918 (eISSN)

Vol. 46 S1 379-382

Ämneskategorier

Fysikalisk kemi

Analytisk kemi

Kemiteknik

DOI

10.1002/sia.5609

Mer information

Senast uppdaterat

2023-08-08