Adapting discrete goods supply chains to support mass customisation of pharmaceutical products
Journal article, 2021

Emerging research within the field of personalised medicines has aimed to enhance patient treatment through the use of pharmaceutical products that are customized to the individual needs and preferences of the patient. The currently dominant production platforms of pharmaceutical products, however, regard a mass production paradigm and are thus unfeasible for the production and provision of personalised medicines. The production platforms are not designed or are intended for a customisation context. Operating such a context with the current supply chain entails challenges such as increasing costs, time to patient and efforts in quality assurance activities. To address these challenges, this paper presents four reconfigured pharmaceutical supply chain designs. A qualitative operational performance assessment elicits the strengths and weaknesses of the respective supply chain design operating in a customisation context. The results suggest that a later point of variegation, i.e., the point in the supply chain where the final customisation is achieved, can relieve the operational effort of the stakeholders in the supply chain while providing the benefits of personalised medicines, i.e., an enhanced treatment outcome of the patient. A trade-off remains, however, between the supply chain’s decreased operational effort and degree of necessary reconfigurations, such as introducing new functions to stakeholder operation, reallocating activities to other stakeholders or educating stakeholders.

Mass Customisation

Supply Chain Reconfiguration

Integrated Design

Pharmaceutical Supply Chain Design

Personalised Medicines

Author

Maria Daniela Irene Siiskonen

Chalmers, Industrial and Materials Science, Product Development

Niels Henrik Mortensen

Technical University of Denmark (DTU)

Johan Malmqvist

Chalmers, Industrial and Materials Science, Product Development

Staffan Folestad

AstraZeneca R&D

Concurrent Engineering Research and Applications

1063-293X (ISSN)

Vol. In Press

Subject Categories

Mechanical Engineering

Areas of Advance

Production

DOI

10.1177/1063293X211002169

More information

Latest update

5/10/2021