Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
Journal article, 2021
The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from birth to 5 years of age, collecting samples after 4 and 12 months and at 3 and 5 years of age as well as from their mothers at birth using 16S rRNA gene profiling. We also compare their microbiota to an adult Swedish population. Genera follow 4 different colonization patterns during establishment where Methanobrevibacter and Christensenellaceae colonize late and do not reached adult levels at 5 years. These late colonizers correlate with increased alpha diversity in both children and adults. By following the children through age-specific community types, we observe that children have individual dynamics in the gut microbiota development trajectory.
16S rRNA
infant microbiota
C-section
developing microbiota
microbiota
longitudinal cohort
Author
Josefine Roswall
Hallands Hospital Halmstad
University of Gothenburg
Lisa M. Olsson
Wallenberg Lab.
P. Kovatcheva-Datchary
Wallenberg Lab.
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Applied Mathematics and Statistics
Valentina Tremaroli
Wallenberg Lab.
Marie Christine Simon
Wallenberg Lab.
Pia Kiilerich
University of Copenhagen
Rozita Akrami
Wallenberg Lab.
Manuela Krämer
Wallenberg Lab.
Mathias Uhlen
Royal Institute of Technology (KTH)
Technical University of Denmark (DTU)
Anders Gummesson
Sahlgrenska University Hospital
Wallenberg Lab.
Karsten Kristiansen
BGI Institute of Applied Agriculture
University of Copenhagen
Jovanna Dahlgren
University of Gothenburg
Sahlgrenska University Hospital
Fredrik Bäckhed
University of Copenhagen
Sahlgrenska University Hospital
Wallenberg Lab.
Cell Host and Microbe
1931-3128 (ISSN) 19346069 (eISSN)
Vol. 29 5 765-776.e3Subject Categories
Pediatrics
Other Medical Sciences not elsewhere specified
Other Health Sciences
DOI
10.1016/j.chom.2021.02.021
PubMed
33794185