Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
Artikel i vetenskaplig tidskrift, 2021
The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from birth to 5 years of age, collecting samples after 4 and 12 months and at 3 and 5 years of age as well as from their mothers at birth using 16S rRNA gene profiling. We also compare their microbiota to an adult Swedish population. Genera follow 4 different colonization patterns during establishment where Methanobrevibacter and Christensenellaceae colonize late and do not reached adult levels at 5 years. These late colonizers correlate with increased alpha diversity in both children and adults. By following the children through age-specific community types, we observe that children have individual dynamics in the gut microbiota development trajectory.
16S rRNA
infant microbiota
C-section
developing microbiota
microbiota
longitudinal cohort
Författare
Josefine Roswall
Hallands Hospital Halmstad
Göteborgs universitet
Lisa M. Olsson
Wallenberg Lab.
P. Kovatcheva-Datchary
Wallenberg Lab.
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik
Valentina Tremaroli
Wallenberg Lab.
Marie Christine Simon
Wallenberg Lab.
Pia Kiilerich
Köpenhamns universitet
Rozita Akrami
Wallenberg Lab.
Manuela Krämer
Wallenberg Lab.
Mathias Uhlen
Kungliga Tekniska Högskolan (KTH)
Danmarks Tekniske Universitet (DTU)
Anders Gummesson
Sahlgrenska universitetssjukhuset
Wallenberg Lab.
Karsten Kristiansen
BGI Institute of Applied Agriculture
Köpenhamns universitet
Jovanna Dahlgren
Göteborgs universitet
Sahlgrenska universitetssjukhuset
Fredrik Bäckhed
Köpenhamns universitet
Sahlgrenska universitetssjukhuset
Wallenberg Lab.
Cell Host and Microbe
1931-3128 (ISSN) 19346069 (eISSN)
Vol. 29 5 765-776.e3Ämneskategorier
Pediatrik
Övrig annan medicin och hälsovetenskap
Annan hälsovetenskap
DOI
10.1016/j.chom.2021.02.021
PubMed
33794185