Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
Artikel i vetenskaplig tidskrift, 2021

The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from birth to 5 years of age, collecting samples after 4 and 12 months and at 3 and 5 years of age as well as from their mothers at birth using 16S rRNA gene profiling. We also compare their microbiota to an adult Swedish population. Genera follow 4 different colonization patterns during establishment where Methanobrevibacter and Christensenellaceae colonize late and do not reached adult levels at 5 years. These late colonizers correlate with increased alpha diversity in both children and adults. By following the children through age-specific community types, we observe that children have individual dynamics in the gut microbiota development trajectory.

infant microbiota

longitudinal cohort

developing microbiota

16S rRNA




Josefine Roswall

Göteborgs universitet

Hallands Hospital Halmstad

Lisa M. Olsson

Wallenberg Lab.

P. Kovatcheva-Datchary

Wallenberg Lab.

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Valentina Tremaroli

Wallenberg Lab.

Marie Christine Simon

Wallenberg Lab.

Pia Kiilerich

Köpenhamns universitet

Rozita Akrami

Wallenberg Lab.

Manuela Krämer

Wallenberg Lab.

Mathias Uhlen

Danmarks Tekniske Universitet (DTU)

Kungliga Tekniska Högskolan (KTH)

Anders Gummesson

Wallenberg Lab.

Sahlgrenska universitetssjukhuset

Karsten Kristiansen


Köpenhamns universitet

Jovanna Dahlgren

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Fredrik Bäckhed

Sahlgrenska universitetssjukhuset

Wallenberg Lab.

Köpenhamns universitet

Cell Host and Microbe

1931-3128 (ISSN)

Vol. 29 5 765-776.e3



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