Acetic acid stress in budding yeast: From molecular mechanisms to applications
Journal article, 2021

Acetic acid stress represents a frequent challenge to counteract for yeast cells under several environmental conditions and industrial bioprocesses. The molecular mechanisms underlying its response have been mostly elucidated in the budding yeast Saccharomyces cerevisiae, where acetic acid can be either a physiological substrate or a stressor. This review will focus on acetic acid stress and its response in the context of cellular transport, pH homeostasis, metabolism and stress-signalling pathways. This information has been integrated with the results obtained by multi-omics, synthetic biology and metabolic engineering approaches aimed to identify major cellular players involved in acetic acid tolerance. In the production of biofuels and renewable chemicals from lignocellulosic biomass, the improvement of acetic acid tolerance is a key factor. In this view, how this knowledge could be used to contribute to the development and competitiveness of yeast cell factories for sustainable applications will be also discussed.

industrial biotechnology


acetic acid stress

Saccharomyces cerevisiae


cell factory


Nicoletta Guaragnella

National Research Council of Italy (CNR)

University of Bari Aldo Moro

Maurizio Bettiga

Chalmers, Biology and Biological Engineering, Industrial Biotechnology

EviKrets Biobased Processes Consultants


0749-503X (ISSN) 1097-0061 (eISSN)

Vol. 38 7 391-400

Cell membrane engineering as a novel target for the improvement of microbial strains for biofuels production: investigating the relationship between membrane constituents and membrane permeability

Swedish Energy Agency (43524-1), 2017-01-01 -- 2020-12-31.

Subject Categories

Cell Biology

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Biocatalysis and Enzyme Technology





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