Acetic acid stress in budding yeast: From molecular mechanisms to applications
Artikel i vetenskaplig tidskrift, 2021

Acetic acid stress represents a frequent challenge to counteract for yeast cells under several environmental conditions and industrial bioprocesses. The molecular mechanisms underlying its response have been mostly elucidated in the budding yeast Saccharomyces cerevisiae, where acetic acid can be either a physiological substrate or a stressor. This review will focus on acetic acid stress and its response in the context of cellular transport, pH homeostasis, metabolism and stress-signalling pathways. This information has been integrated with the results obtained by multi-omics, synthetic biology and metabolic engineering approaches aimed to identify major cellular players involved in acetic acid tolerance. In the production of biofuels and renewable chemicals from lignocellulosic biomass, the improvement of acetic acid tolerance is a key factor. In this view, how this knowledge could be used to contribute to the development and competitiveness of yeast cell factories for sustainable applications will be also discussed.

industrial biotechnology


acetic acid stress

Saccharomyces cerevisiae


cell factory


Nicoletta Guaragnella

Consiglio Nazionale delle Ricerche (CNR)

Universita degli Studi di Bari Aldo Moro

Maurizio Bettiga

Chalmers, Biologi och bioteknik, Industriell bioteknik

EviKrets Biobased Processes Consultants


0749-503X (ISSN) 1097-0061 (eISSN)

Vol. In Press

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Energimyndigheten (43524-1), 2017-01-01 -- 2020-12-31.



Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Biokatalys och enzymteknik





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