A time-resolved proteomic and prognostic map of COVID-19
Journal article, 2021
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease.
patient trajectories
disease prognosis
physiological parameters
clinical disease progression
machine learning
longitudinal profiling
COVID-19
proteomics
biomarkers
Author
Vadim Demichev
Charité University Medicine Berlin
Pinkus Tober-Lau
Charité University Medicine Berlin
Oliver Lemke
Charité University Medicine Berlin
Tatiana Nazarenko
University College London (UCL)
Charlotte Thibeault
Charité University Medicine Berlin
Harry Whitwell
Imperial College London
Annika Röhl
Charité University Medicine Berlin
Anja Freiwald
Charité University Medicine Berlin
Lukasz Szyrwiel
The Francis Crick Institute
Daniela Ludwig
Charité University Medicine Berlin
Clara Correia-Melo
The Francis Crick Institute
Simran Kaur Aulakh
The Francis Crick Institute
Elisa T. Helbig
Charité University Medicine Berlin
Paula Stubbemann
Charité University Medicine Berlin
Lena J. Lippert
Charité University Medicine Berlin
Nana-Maria Grüning
Charité University Medicine Berlin
Oleg Blyuss
Lobachevsky University
Spyros I. Vernardis
The Francis Crick Institute
Matthew White
The Francis Crick Institute
Christoph B. Messner
Charité University Medicine Berlin
Michael Joannidis
Medical University of Innsbruck
Thomas Sonnweber
Medical University of Innsbruck
Sebastian J. Klein
Medical University of Innsbruck
Alex Pizzini
Medical University of Innsbruck
Yvonne Wohlfarter
Medical University of Innsbruck
Sabina Sahanic
Medical University of Innsbruck
Richard Hilbe
Medical University of Innsbruck
Benedikt Schaefer
Medical University of Innsbruck
Sonja Wagner
Medical University of Innsbruck
Mirja Mittermaier
Charité University Medicine Berlin
Felix Machleidt
Charité University Medicine Berlin
Carmen Garcia
Charité University Medicine Berlin
Christoph Ruwwe-Glösenkamp
Charité University Medicine Berlin
Tilman Lingscheid
Charité University Medicine Berlin
Laure Bosquillon de Jarcy
Charité University Medicine Berlin
Miriam S. Stegemann
Charité University Medicine Berlin
Moritz Pfeiffer
Charité University Medicine Berlin
Linda Jürgens
Charité University Medicine Berlin
Sophy Denker
Charité University Medicine Berlin
Daniel Zickler
Charité University Medicine Berlin
Philipp Enghard
Charité University Medicine Berlin
Aleksej Zelezniak
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
The Francis Crick Institute
Archie Campbell
University of Edinburgh
Caroline Hayward
University of Edinburgh
David J. Porteous
University of Edinburgh
Riccardo E. Marioni
University of Edinburgh
Alexander Uhrig
Charité University Medicine Berlin
Holger Müller-Redetzky
Charité University Medicine Berlin
Heinz Zoller
Medical University of Innsbruck
Judith Löffler-Ragg
Medical University of Innsbruck
M. A. Keller
Medical University of Innsbruck
Ivan Tancevski
Medical University of Innsbruck
John F. Timms
University College London (UCL)
Alexey Zaikin
University College London (UCL)
Stefan Hippenstiel
Charité University Medicine Berlin
Michael Ramharter
Universitatsklinikum Hamburg-Eppendorf und Medizinische Fakultat
Martin Witzenrath
Charité University Medicine Berlin
Norbert Suttorp
Charité University Medicine Berlin
Kathryn Lilley
University of Cambridge
Michael Mülleder
Charité University Medicine Berlin
Leif Erik Sander
Charité University Medicine Berlin
Malte Kleinschmidt
Katrin M. Heim
Berliner Institut für Gesundheitsforschung
Belén Millet
Lil Meyer-Arndt
Charité University Medicine Berlin
Ralf H. Hübner
Charité University Medicine Berlin
Tim Andermann
Charité University Medicine Berlin
Jan M. Doehn
Berliner Institut für Gesundheitsforschung
Bastian Opitz
Birgit Sawitzki
Charité University Medicine Berlin
Daniel Grund
Charité University Medicine Berlin
Peter Radünzel
Charité University Medicine Berlin
Mariana Schürmann
Charité University Medicine Berlin
Thomas Zoller
Medical University of Innsbruck
Florian Alius
Charité University Medicine Berlin
Philipp Knape
Charité University Medicine Berlin
Astrid Breitbart
Charité University Medicine Berlin
Yaosi Li
Berliner Institut für Gesundheitsforschung
Felix Bremer
Charité University Medicine Berlin
Panagiotis Pergantis
Charité University Medicine Berlin
Dirk Schürmann
Bettina Temmesfeld-Wollbrück
Berliner Institut für Gesundheitsforschung
Daniel Wendisch
Berliner Institut für Gesundheitsforschung
Sophia Brumhard
Charité University Medicine Berlin
Sascha S. Haenel
Charité University Medicine Berlin
Claudia Conrad
Charité University Medicine Berlin
Philipp Georg
Charité University Medicine Berlin
Kai-Uwe Eckardt
Charité University Medicine Berlin
Lukas Lehner
Jan M. Kruse
Charité University Medicine Berlin
Carolin Ferse
Roland Körner
Berliner Institut für Gesundheitsforschung
Claudia Spies
Andreas Edel
Steffen Weber-Carstens
Berliner Institut für Gesundheitsforschung
Alexander Krannich
Charité University Medicine Berlin
Saskia Zvorc
Charité University Medicine Berlin
Linna Li
Uwe Behrens
Charité University Medicine Berlin
Sein Schmidt
Charité University Medicine Berlin
Maria Rönnefarth
Berliner Institut für Gesundheitsforschung
Chantip Dang-Heine
Charité University Medicine Berlin
Robert Röhle
Charité University Medicine Berlin
Emma Lieker
Lucie Kretzler
Berliner Institut für Gesundheitsforschung
Isabelle Wirsching
Charité University Medicine Berlin
Christian Wollboldt
Charité University Medicine Berlin
Yinan Wu
Georg Schwanitz
Charité University Medicine Berlin
David Hillus
Charité University Medicine Berlin
Stefanie Kasper
Nadine Olk
Charité University Medicine Berlin
Alexandra Horn
Dana Briesemeister
Charité University Medicine Berlin
Denise Treue
Berliner Institut für Gesundheitsforschung
Michael Hummel
Charité University Medicine Berlin
Victor M. Corman
Charité University Medicine Berlin
C. Drosten
Charité University Medicine Berlin
Christof von Kalle
German Cancer Research Center (DKFZ)
M. Ralser
Charité University Medicine Berlin
Florian Kurth
Charité University Medicine Berlin
Cell Systems
24054712 (ISSN) 24054720 (eISSN)
Vol. 12 8 780-794.e7Subject Categories
Clinical Laboratory Medicine
Biomedical Laboratory Science/Technology
Pharmacology and Toxicology
DOI
10.1016/j.cels.2021.05.005
PubMed
34139154