Radiobiological modeling of hyperthermia combined with Gamma-Knife radiosurgery in pediatric brain cancer
Other conference contribution, 2021

Assessment of the synergistic effect of radiotherapy (RT) and hyperthermia (HT) in clinical settings is crucial for further expansion of hyperthermia. The radiobiological modeling using an extended version of the LQ model with temperature-dependent radiosensitivity parameters has been suggested in combination with external beam radiotherapy in previous studies. This study investigates the radiobiological effect of intracranial hyperthermia combined with stereotactic radiosurgery (SRS) in pediatric brain cancers. The hyperthermia treatment plan was achieved with an elliptical applicator consisting of 16 ORWG antennas working at 400 MHz and a hybrid Specific Absorption Rate (SAR) optimization procedure based on Time-Reversal and PSO. The radiotherapy plan was created by the treatment planning software of Leksell Gamma Knife® Icon™.

stereotactic radiotherapy

medulloblastoma

biological modelling

hyperthermia

Author

Morteza Ghaderi Aram

Chalmers, Electrical Engineering, Signal Processing and Biomedical Engineering, Biomedical Electromagnetics

Håkan Nordström

Elekta

Iuliana Toma-Dasu

Karolinska Institutet

Klas Blomgren

Karolinska University Hospital

Hana Dobsicek Trefna

Chalmers, Electrical Engineering, Signal Processing and Biomedical Engineering, Biomedical Electromagnetics

13th International Congress of Hyperthermic Oncology (ICHO2021)
Online, ,

Subject Categories

Other Medical Engineering

Probability Theory and Statistics

Areas of Advance

Health Engineering

More information

Latest update

10/6/2021