Radiobiological modeling of hyperthermia combined with Gamma-Knife radiosurgery in pediatric brain cancer
Artikel i vetenskaplig tidskrift, 2021

Assessment of the synergistic effect of radiotherapy (RT) and hyperthermia (HT) in clinical settings is crucial for further expansion of hyperthermia. The radiobiological modeling using an extended version of the LQ model with temperature-dependent radiosensitivity parameters has been suggested in combination with external beam radiotherapy in previous studies. This study investigates the radiobiological effect of intracranial hyperthermia combined with stereotactic radiosurgery (SRS) in pediatric brain cancers. The hyperthermia treatment plan was achieved with an elliptical applicator consisting of 16 ORWG antennas working at 400 MHz and a hybrid Specific Absorption Rate (SAR) optimization procedure based on Time-Reversal and PSO. The radiotherapy plan was created by the treatment planning software of Leksell Gamma Knife® Icon™.

biological modelling

hyperthermia

medulloblastoma

stereotactic radiotherapy

Författare

Morteza Ghaderi Aram

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

Håkan Nordström

Elekta

Iuliana Toma-Dasu

Karolinska Institutet

Klas Blomgren

Karolinska universitetssjukhuset

Hana Dobsicek Trefna

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

Cancers

2072-6694 (ISSN)

Vol. 13 13 3277

Ämneskategorier

Annan medicinteknik

Sannolikhetsteori och statistik

Styrkeområden

Hälsa och teknik

DOI

10.3390/cancers13133277

Mer information

Senast uppdaterat

2022-06-29