Ruthenium-Catalyzed Azide Alkyne Cycloaddition (RuAAC)
Book chapter, 2021
Under ruthenium catalysis, 1,5-disubstituted 1,2,3-triazoles can be accessed with high selectivity from terminal alkynes and organic azides via a ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) reaction. In addition, these conditions allow the use of internal alkynes, providing access to 1,4,5-trisubstituted 1,2,3-triazoles. This chapter reviews the scope and limitations of the RuAAC reaction, as well as selected applications. A brief mention of AAC reaction catalyzed by other metals is also included.
carbon-nitrogen bonds
triazoles
nitrogen heterocycles
ruthenium catalysts
cycloaddition
azides
alkynes
Author
Andrew Paterson
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Tamas Beke-Somfai
Hungarian Academy of Sciences
Nina Kann
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Science of Synthesis: Click Chemistry
289-335
9783132435568 (ISBN)
Areas of Advance
Nanoscience and Nanotechnology
Health Engineering
Materials Science
Subject Categories
Organic Chemistry
DOI
10.1055/sos-SD-235-00118