Ruthenium-Catalyzed Azide Alkyne Cycloaddition (RuAAC)

Kapitel i bok, 2021

Under ruthenium catalysis, 1,5-disubstituted 1,2,3-triazoles can be accessed with high selectivity from terminal alkynes and organic azides via a ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) reaction. In addition, these conditions allow the use of internal alkynes, providing access to 1,4,5-trisubstituted 1,2,3-triazoles. This chapter reviews the scope and limitations of the RuAAC reaction, as well as selected applications. A brief mention of AAC reaction catalyzed by other metals is also included.