Spectral analysis of burst periods in EEG from healthy and post-asphyctic full-term neonates
Journal article, 2004

OBJECTIVE: To investigate whether the periodic EEG patterns seen in healthy and sick full term neonates (trace alternant and burst suppression, respectively) have different frequency characteristics. METHODS: Burst episodes were selected from the EEGs of 9 healthy and 9 post-asphyctic full-term neonates and subjected to power spectrum analysis. Powers in two bands were estimated; 0-4 and 4-30 Hz, designated low- and high-frequency activity, respectively (LFA, HFA). The spectral edge frequency (SEF) was also assessed. RESULTS: In bursts, the LFA power was lower in periods of burst suppression as compared to those of trace alternant. The parameter that best discriminated between the groups was the relative amount of low- and high-frequency activity. The SEF parameter had a low sensitivity to the group differences. In healthy neonates, the LFA power was higher over the posterior right as compared to the posterior left region. CONCLUSIONS: Spectral power of low frequencies differs significantly between the burst episodes of healthy and sick neonates. SIGNIFICANCE: These results can be used when monitoring cerebral function in neonates.

Case-Control Studies

Asphyxia Neonatorum/diagnosis/*physiopathology

Newborn

*Electroencephalography

Humans

Infant

Sensitivity and Specificity

Author

M. Thordstein

Sahlgrenska University Hospital

Anders Flisberg

University of Gothenburg

Nils Löfgren

Chalmers, Signals and Systems

Ralph Bågenholm

University of Gothenburg

Kaj Lindecrantz

University of Borås

B. G. Wallin

Sahlgrenska University Hospital

Ingemar Kjellmer

University of Gothenburg

Clinical Neurophysiology

1388-2457 (ISSN)

Vol. 115 11 2461-6

Subject Categories

MEDICAL AND HEALTH SCIENCES

DOI

10.1016/j.clinph.2004.05.019

PubMed

15465433

More information

Latest update

4/17/2018